Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. PAD enzymes catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. All enzymes are cytosolic except for…

Source: Active recombinant N-terminal His-tagged protein expressed in Sf21 cells Mr: 96.3 kDa Recombinant Gcn5 preferentially acetylates lysine 14 on histone H3 in vitro; however, alone it is unable to acetylate nucleosomal core histone substrates. Acetylation of the nucleosomal histones…

Source: Recombinant N-terminal His- and SUMOpro-tagged protein expressed in E. coli Mr: 34.5 kDa

Source: Recombinant protein expressed in E. coli Mr: 45.6 kDa

Streptavidin conjugated to Alkaline Phosphatase Binding Moiety: Streptavidin Enzyme: Alkaline Phosphatase Uses: Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 42.6 kDa This product contains the tudor domain of TP53BP1. Binding of TP53BP1 to dimethylated lysine 382 on p53 (p53 K382me2), as well as histone H4K20me2, through the tudor domain, has been shown to be important for…

Source: Active recombinant N-terminal proprietary tagged protein expressed in E. coli UTX plays a crucial role in epigenetic regulation of gene expression by catalyzing the demethylation of tri-methylated lysine 27 on histone H3.

Source: Active recombinant C-terminal His-tag expressed in E. coli MW: 45.3 kDa HDAC8 is a Class I HDAC that catalyzes the deacetylation of core histones, resulting in tightening of nucleosomal integrity, restricting access to transcription factors, and suppression of transcription. It can…

A bioactive peptide fragment derived from hemoglobin a 1 chain; exhibits potent vasoactive biological activity, reducing rat blood pressure over a dosage range of 0.1-10 μg/kg; also a potent central cannabinoid (CB1) receptor antagonist conferring analgesia and pain relief or antinociception in vivo.

Source: Recombinant protein expressed in E. coli RbBP5 is a ubiquitously expressed nuclear protein that contains WD40 repeat-like domains. RbBP5 binds directly to tumor suppressor retinoblastoma protein (RB) and regulates cell proliferation. RbBP5 is also an important component of the…

Source: recombinant N-terminal His-tagged protein expressed in E. coli Mr: 19.3 kDa

Source: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli Mr: 19.3 kDa Protein concentration: 1.0 mg/ml

Source: Recombinant protein expressed in E. coli MW: 13.72 kDa PLA2 (Type V) is a secretory PLA2 (sPLA2) that catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids. It is responsible for arachidonic acid mobilization leading to prostaglandin production in…

Source: recombinant His-tagged protein purified from E. coli Mr: ~34 kDa PPARα transcriptionally regulates a variety of genes involved in fatty acid metabolism and oxidation, such as acyl-CoA oxidase, enol-CoA hydratase, medium chain fatty acyl-CoA dehydrogenase, fatty acid transport…

EC 3.1.1.4 Active enzyme isolated from bee venom One unit of enzyme hydrolyzes one µmol of Diheptanoyl Thio-PC per minute at 25°C PLA2 catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid. PLA2…

Active, purified human recombinant enzyme.

Source: human recombinant N-terminal His-tagged protein expressed in E. coli Mr: ~60 kDa PPARs are members of the nuclear receptor family of ligand activated transcription factors that heterodimerize with retinoic acid like receptors, regulating gene expression and differentiation.…

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 40.8 kDa CREBBP bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53.

Source: recombinant protein expressed in E. coli. An N-terminal His-tag and SUMOpro tag were removed by cleavage with SUMO protease 1 (Ulp1). Mr: 12.4 kDa

Source: Recombinant GST-tagged protein expressed in E. coli Mr: 71.2 kDa The isolated individual or tandem bromodomains of BRD2 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.

Recombinant protein expressed in Sf21 cells using the Baculovirus system One unit is defined as the amount of enzyme required to consume 1 nmol of oxygen per minute 37°C in 100 mM Tris, pH 8.0, containing 100 µM arachidonate, 5 mM EDTA, 2 mM phenol, and 1 µM hematin.

Source: Active recombinant enzyme expressed in E. coli A soluble enzyme induced by LPS and cytokines that is responsible for the biosynthesis of NO from L-arginine; one unit of enzyme produces 1 µmol of NO per minute at 37°C in 50 mM HEPES, pH 7.4, containing 1 mM arginine, 1 mM…

Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin (TIG2) has been identified as the natural ligand for this receptor. Resolvin…

Source: 50 µg of full length recombinant C-terminal His- and FLAG-tagged protein expressed in baculovirus expression system Mr: 56 kDa HDAC1 is a Class I HDAC that catalyzes the deacetylation of core histones and other non-histone proteins to control complex biological events, including…

Source: 10 µg of recombinant N-terminal GST-tagged protein expressed in baculovirus expression system Mr: 75.2 kDa HDAC4 is a Class IIa HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of nonhistone substrates.

Source: Active recombinant enzyme expressed in E. coli MW: 46 kDa Lipocalin-type prostaglandin D synthase (L-PGDS) catalyzes the isomerization of PGH2 to produce PGD2 and acts as a carrier protein for lipid-like molecules (i.e., retinoids and thyroid hormones).

Source: Purified from human plasma, citrullinated with human recombinant PAD2 MW: α chain isoform 1 (95 kDa), α chain isoform 2 (69.8 kDa), β chain (55.9k Da), and,isoform γ-B chain (51.5 kDa)

Adenosine Receptor A_2A is a multi-pass membrane protein that is normally localized to the plasma membrane. This receptor is part of the G-protein coupled receptor family that binds adenosine and keeps it in equilibrium inside and outside the cell. Along with establishing this…

Recombinant enzyme isolated from a Baculovirus overexpression system in Sf21 cells.

Source: Active recombinant N-terminal His-tagged protein amino acids 190-352, expressed in E. coli Mr: 21.1 kDa SET8 selectively mono-methylates histone H4 at lysine 20, an event proven to have an important role in chromatin structure and transcriptional activation. SET8 is also a novel…

Source: recombinant N-terminal GST-tagged protein purified from E. coli Mr: ~45.2 kDa (18.9 kDa native; 26.3 kDa GST-tagged) PtdIns-(4,5)-P2 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2. PtdIns-(4,5)-P2 can be phosphorylated by…

Source: Recombinant N-terminal His-tagged protein expressed in E. coli MW: 40.48 kDa Annexin A1 is an endogenous mediator of inflammation, promoting resolution in a number of ways. Normally expressed in intracellular compartments, it is drawn to the cell membrane and both induced and…