Cayman Chemical

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Cayman Chemical

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  • (1S,3R)-3-Hydroxycyclopentane acetic acid methyl ester

    Cayman Chemical

    A synthetic intermediate useful for pharmaceutical synthesis.

  • O-7460

    Cayman Chemical

    A selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM); 0-12 mg/kg, i.p. in mice dose-dependently inhibits high-fat diet intake and reduces body weight.

  • HHATL Polyclonal Antibody

    Cayman Chemical

    Antigen: human HHATL, C-terminal region Host: rabbit Cross Reactivity: (+) human Application: FC, IF, and WB

  • MS 245 (oxalate)

    Cayman Chemical

    Molecular Formula C19H22N2O3S • C2H2O4 Formula Weight 448.5

  • Palmitoyl Ethanolamide-d4

    Cayman Chemical

    An internal standard for the quantification of PEA.

  • Annexin V FITC Assay Kit

    Cayman Chemical

    One of the hallmarks of the early stages of apoptosis is the redistribution of membrane phospholipids such as phosphatidylserine and phosphatidylethanolamine from the inner to outer leaflet of the membrane bilayer where they are exposed on the cell surface. Externalization of phosphatidylserine…

  • Phenformin (hydrochloride)

    Cayman Chemical

    Biguanide derivative that improves insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMPK-dependent signaling; inhibits peripheral glucose oxidation, has an associated effect of inducing lactic acidosis when not…

  • Conessine

    Cayman Chemical

    A naturally occurring steroid alkaloid that acts as a potent histamine H3 receptor antagonist (Kis = 5.2 and 24.5 nM for rat and human, respectively) that efficiently crosses the blood-brain barrier but has a poor rate of CNS clearance.

  • CAY10698

    Cayman Chemical

    A selective inhibitor of 12-LO with an IC50 value of 5.1 µM.

  • L-AP4

    Cayman Chemical

    A selective Group III metabotropic glutamate receptor agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM); depresses synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina.

  • LL-Z 1640-4

    Cayman Chemical

    A resorcylic acid lactone with antiviral and antiprotozoan activity; used as negative control for MAPKKK inhibitor (5Z)-7-oxo zeaenol (Item No. 17459).

  • (±)7(8)-EpDPA

    Cayman Chemical

    An epoxide derivative of DHA that is generated by the action of CYP450 epoxygenases; naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids; a substrate of soluble epoxide hydrolase (KM = 15 µM).

  • 2-Pyrimidin-2-yl-Propionic Acid

    Cayman Chemical

    2-Pyrimidin-2-yl-propionic acid is a synthetic intermediate useful for pharmaceutical synthesis.

  • Auraptene

    Cayman Chemical

    A coumarin derived from citrus plants with anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities; inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.

  • SQ 29,548

    Cayman Chemical

    Selective TXA2 receptor antagonist (Ki = 4.1 nM); inhibits U-46619-induced platelet aggregation (IC50 = 0.06 µM).

  • CGP 35348

    Cayman Chemical

    A selective, brain-accessible GABAB receptor antagonist (IC50 = 34 µM).

  • Lipoxygenase from Glycine max (soybean) - Purified

    Cayman Chemical

    Active, pure recombinant enzyme.

  • 5(S),6(R)-11-trans DiHETE

    Cayman Chemical

    5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in…

  • CREB (Phospho-Ser133) Polyclonal Antibody

    Cayman Chemical

    Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser133 of rat CREB Host: rabbit Cross-reactivity: (+) rat CREB Application: WB CREB is one of the best characterized stimulus-induced transcription factors. This transcription factor is a component of…

  • trans-?2-11-methyl-Dodecenoic Acid

    Cayman Chemical

    trans-.DELTA.2-11-methyl-Dodecenoic acid is the conformational isomer of cis-.DELTA.2-11-methyl-dodecenoic acid, a diffusible signal factor (DSF) in extracellular microbial and fungal communication systems.

  • 3-Deaza-2'-deoxyadenosine

    Cayman Chemical

    Strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM; can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.

  • Rivaroxaban

    Cayman Chemical

    An orally active, direct inhibitor of Factor Xa (Ki = 0.4 nM) that inhibits thrombin formation without prolonging bleeding time; approved for clinical use as an anticoagulant in the prevention of stroke and the treatment of venous thromboembolisms.

  • 4-tert-Octylphenol diethoxylate

    Cayman Chemical

    A degradation product of the surfactant, Triton X that produces weak estrogenic effects in animal and human research studies.

  • ?2-cis Eicosenoic Acid

    Cayman Chemical

    .DELTA.2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats. .DELTA.2-cis…

  • CAY10566

    Cayman Chemical

    A potent, selective inhibitor of Stearoyl-CoA desaturase 1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.

  • (±)12(13)-EpOME-d4

    Cayman Chemical

    (±)12(13)-EpOME-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-MS.

  • Cortisol Express ELISA Kit

    Cayman Chemical

    Cayman's Cortisol Express ELISA is a competitive assay that permits the rapid measurement of cortisol from biological samples, requiring only a two hour incubation and one hour development times.

  • YS-035 (hydrochloride)

    Cayman Chemical

    A verapamil derivative that dose-dependently blocks calcium uptake via Na+/Ca2+ exchange in diverse types of cells (Ki = 28 µM); also prevents calcium release from mitochondria induced by Ruthenium Red but not by uncouplers, respiratory inhibitors, or a chelating agent.

  • Piroxicam

    Cayman Chemical

    An NSAID that non-selectively and reversibly inhibits both COX isoforms (IC50 = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).

  • Nrf2 Transcription Factor Assay Kit

    Cayman Chemical

    Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that plays a key role in maintaining redox homeostasis via its interaction with a cysteine-rich protein Kelch-like ECH-associated protein 1 (Keap1). In resting cells, Nrf2 and Keap1 form a tight complex, which is targeted for…

  • 13,14-dihydro Prostaglandin E1

    Cayman Chemical

    13,14-dihydro PGE1 is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent…

  • SU 5402

    Cayman Chemical

    An inhibitor of the tyrosine kinase domains of VEGFR2, FGFR1, and PDGFRβ (IC50s = 0.02, 0.03, and 0.51 µM, respectively).

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