Source: Active recombinant N-terminal His-tagged protein amino acids 190-352, expressed in E. coli
Mr: 21.1 kDa
SET8 selectively mono-methylates histone H4 at lysine 20, an event proven to have an important role in chromatin structure and transcriptional activation. SET8 is also a novel regulator of p53, mono-methylating lysine 382 of the tumor suppressor. SET8’s ability to suppress p53 transcriptional activity implies that it may play a significant role in tumorigenesis.