Cayman Chemical

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Cayman Chemical

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  • (R)-3-hydroxy Myristic Acid

    Cayman Chemical

    A form of the myristic acid that is found in the lipid A component of some Gram negative bacteria, including Escherichia, Haemophilus, Actinobacillus, and Campylobacter species.

  • Tandutinib

    Cayman Chemical

    A potent antagonist of the type III receptor tyrosine kinases PDGFRβ, FLT3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively); less potently inhibits CSF-1R (IC50 = 3.4 µM) and does not significantly inhibit other tyrosine or serine/threonine kinases.

  • Swinholide A

    Cayman Chemical

    A natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.

  • Ketotifen (fumarate)

    Cayman Chemical

    A second generation histamine H1 receptor antagonist (IC50 = 1.3 nM) and mast cell stabilizer; inhibits the quick phase reaction in a rat antigen-induced immediate airway response model.

  • Polymyxin B1 Isoleucine

    Cayman Chemical

    Differs from polymyxin B1 by having isoleucine rather than leucine as a component of the cyclic peptide; comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates.

  • PGF2α tromethamine salt is a crystalline derivative of PGF2α with increased water solubility. Its solubility in PBS is 25 mg/ml compared to 10 mg/ml for PGF2α.

  • BDP-12

    Cayman Chemical

    Synonyms Ampakine CX-516 Ampalex CX-516

  • Fast Green FCF

    Cayman Chemical

    A dye used to stain proteins for IEF and SDS-PAGE; fluoresces near infrared (absorption maximum: 624 nm).

  • KT 5823

    Cayman Chemical

    A potent, selective inhibitor of PKG (in vitro IC50 = 234 nM); cell-permeable and often used in intact cells to assess the role of PKG in signaling.

  • An intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi; metabolized by a variety of enzymes in mammals, including N-acetyltransferases; may also be utilized by bacteria or fungi that are living in mammalian organisms.

  • Ganciclovir

    Cayman Chemical

    A synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections; inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig.

  • Brefeldin A

    Cayman Chemical

    A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum; directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf activation associated with vesicular transport (IC50 =…

  • AZ 7371

    Cayman Chemical

    AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2’-epimerase (DprE1) with an IC50 value of 10 nM. It also inhibits PDE6 with an IC50 value of 4 µM. AZ 7371 has been shown to be active against M. tuberculosis with an MIC range of…

  • Pyocyanin

    Cayman Chemical

    Activates the aryl hydrocarbon receptor (Ki = 5.4 µM), inducing the expression of both detoxifying enzymes, resulting in pyocyanin degradation, and cytokines that facilitate the clearance of bacteria; accelerates neutrophil apoptosis, resulting in resolution of acute inflammation.

  • For the induction of a respiratory burst response in neutrophils and monocytes, and quantification by flow cytometry. Samples include whole blood from any species or cells of any type that are capable of producing a NADPH oxidase-dependent respiratory burst Induce and quantify a…

  • Mirin

    Cayman Chemical

    An inhibitor of the DNA damage sensor MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM); prevents activation of ATM by blocking the nuclease activity of Mre11; induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed…

  • Ketorolac

    Cayman Chemical

    An NSAID, non-selective COX inhibitor, being marketed as an analgesic to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation; inhibits COX-1 and COX-2 (IC50s = 20 nM) in vivo.

  • 19(R)-hydroxy PGF1α is an ω-1 hydroxylase metabolite of PGF1α that has been identified in the semen of humans and marsupials. There are no published reports on its biological activity.

  • 15(S)-Latanoprost

    Cayman Chemical

    An analog of latanoprost in which the hydroxyl at C-15 is inverted relative to latanoprost; binds to the FP receptor in the cat iris sphincter muscle with an IC50 value of 24 µM (tested as the free acid); potential impurity in latanoprost bulk drug preparations.

  • Caffeic Acid

    Cayman Chemical

    Caffeic acid is an inhibitor of 5-LO with an IC50 value of 3.7-72 µM and 12-LO with an IC50 value of 5.1-30 µM.

  • Prodigiosin

    Cayman Chemical

    A natural red bacterial pigment that has antibiotic, antitumor, and immunosuppressant properties; blocks T cell proliferation at a concentration of 30 ng/ml, by interfering with IL-2 receptor expression; induces apoptosis in cancer cells by diverse mechanisms and rescues deficient p53 signaling.

  • HT-2 Toxin

    Cayman Chemical

    An active, deacetylated metabolite of T-2 toxin; inhibits protein synthesis and cell proliferation in plants; causes acute and chronic toxic effects in animals that ingest contaminated plant materials.

  • Carbaprostacyclin

    Cayman Chemical

    Carbaprostacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. This implies rapid metabolic inactivation of carbaprostacyclin. Carbaprostacyclin inhibits platelet…

  • A potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively; less effectively inhibits NHE4 (IC50 ≥10 μM).

  • Pyroxamide

    Cayman Chemical

    An inhibitor of HDAC, including HDAC1 (IC50 = 0.1-0.2 μM); induces growth suppression and cell death of certain types of cancer cells in culture.

  • Source: Active human recombinant N-terminal His-tagged protein purified from Sf21 cells Mr: 64 kDa sEH catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which are known for their vasodialatory…

  • CAY10406

    Cayman Chemical

    A trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases-3 and -7.

  • Nafamostat (mesylate)

    Cayman Chemical

    A serine proteases inhibitor that is capable of inhibiting trypsin (a digestive system protease; Ki = 15 nM), tryptase (a mast cell protease; Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.84 μM); 300 mg/kg decreases the total number of eosinophils…

  • 16,16-dimethyl PGF2β is a metabolically stable analog of PGF2β. It prevents bronchospasm in asthmatics but is less potent than PGE2.

  • An analog of (±)14(15)-EpEDE with greater lipid solubility than the free base.

  • MS37452

    Cayman Chemical

    A competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM); derepresses transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells at 250 µM.

  • (±)-Felodipine

    Cayman Chemical

    An L-type calcium channel blocker that is selective over N-, R-, P/Q- and T-type calcium channels; displays antihypertensive activity, lowering arterial blood pressure without altering cardiac contractility.

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