A neurotoxin produced by C. tetani that is taken up by presynaptic terminals at the neuromuscular junction and blocks inhibitory neurotransmitter release.

EC 3.1.1.4 Active enzyme isolated from bee venom One unit of enzyme hydrolyzes one µmol of Diheptanoyl Thio-PC per minute at 25°C PLA2 catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid. PLA2…

GPR17 is a G protein-coupled receptor that has been identified as a dualistic receptor recognizing signals from two unrelated chemical families: nucleotides and cysteinyl leukotrienes (CysLTs). The deorphanization of GPR17 supports the suggested crosstalk between nucleotides and CysLTs during…

Source: Active recombinant N-terminal proprietary tagged protein expressed in E. coli UTX plays a crucial role in epigenetic regulation of gene expression by catalyzing the demethylation of tri-methylated lysine 27 on histone H3.

Source: Recombinant protein expressed in E. coli Mr: 45.6 kDa

A positive control for Western blots.

A multimeric enterotoxin that catalyzes the ADP-ribosylation of the Gsα protein, which activates adenylate cyclase and increases the intracellular concentration of cAMP; causes the hypersecretion of chloride and bicarbonate ions, which results in increased fluid secretion and the severe…

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 38.2 kDa

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 57.6 kDa

Source: Recombinant GST-tagged protein expressed in E. coli Mr: 73.4 kDa The isolated individual or tandem bromodomains of BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 52.4 kDa

Source: Recombinant protein expressed in E. coli MW: 12.5 kDa

Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. PAD enzymes catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. All enzymes are cytosolic except for…

Active, pure recombinant enzyme.

Source: Human recombinant PP2A catalytic subunit expressed in insect cells with an N-terminal octahistidine-tag followed by a streptactin-tag. The C-terminal leucine 309 was deleted. MW: 38.6 kDa PP2A is a divalent cation-independent protein serine/threonine phosphatase involved in regulating…

The principal cytotoxic component of bee venom; assembles as tetramers on membrane surfaces to form pores, resulting in cell death.

Active recombinant N-terminal GST-tagged protein expressed in E. coli • G9a-like protein (GLP) is a SET domain-containing methyltransferases that specifically mono- and di-methylate histone H3 at lysine 9 (H3K9).

Streptavidin HRP Binding Moiety: Streptavidin Enzyme: Horseradish Peroxidase Uses: Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.

Source: Active recombinant enzyme expressed in E. coli A soluble enzyme induced by LPS and cytokines that is responsible for the biosynthesis of NO from L-arginine; one unit of enzyme produces 1 µmol of NO per minute at 37°C in 50 mM HEPES, pH 7.4, containing 1 mM arginine, 1 mM…

Source: Recombinant N-terminal His-tagged protein expressed in E. coli MW: 40.48 kDa Annexin A1 is an endogenous mediator of inflammation, promoting resolution in a number of ways. Normally expressed in intracellular compartments, it is drawn to the cell membrane and both induced and…

Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant protein kinase.

Recombinant enzyme isolated from a Baculovirus overexpression system in Sf21 cells.

Source: Active recombinant C-terminal His-tagged protein expressed in E. coli Mr: ~37 kDa Protein concentration: 0.8 mg/ml Human PGFS catalyzes the isomerization of PGH2 to PGF2a (PGH2 9,11-endoperoxide reductase activity), as well as the formation of 11b-PGF2a from PGD2 (PGD2…

Source: Active recombinant N-terminal His-tagged protein expressed in Sf21 insect cells MW: 118.3 kDa

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 37 kDa MeCP2 specifically binds to methylated promoters on CpG islands and mediates gene silencing by recruiting corepressor complexes. In vitro work suggests high affinity binding of MeCP2 is facilitated by DNA…

Source: 50 µg of recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 39 kDa NcoR2 is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. HDACs can mediate nuclear receptor functions by forming co-repressor complexes…

Source: one ampoule contains salt-free GRX from E. coli Mr: 10 kDa

An intact toxin that catalyzes the ADP-ribosylation and inactivation of EF-2, terminating protein synthesis and causing cell death.

MW: 135 kDa Source: recombinant enzyme; isolated from a Baculovirus overexpression system in Sf9 cells

Source: recombinant His-tagged protein purified from E. coli Mr: ~21 kDa

Source: 50 µg of a complex of full length recombinant C-terminal His-tagged HDAC3 and recombinant N-terminal GST-tagged NCOR2 amino acids 395-489, co-expressed in baculovirus expression system Mr: 49.7 kDa (HDAC3); 37.6 kDa (NCOR2) HDAC3 is a Class I HDAC that is inactive alone and…

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 40.8 kDa CREBBP bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53.