Biologically Active Small Molecules

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Cayman Chemical Biologically Active Small Molecules

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  • Philanthotoxin 74 (hydrochloride)

    Cayman Chemical

    A subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM); inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM.

  • (±)5-HETE

    Cayman Chemical

    (±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. It contains equal amounts of 5(S)-HETE and 5(R)-HETE. (±)5-HETE induces the aggregation of isolated neutrophils with an IC50 value of 200 nM.

  • Linezolid

    Cayman Chemical

    A synthetic oxazolidinone antibiotic active against a wide range of Gram-positive bacteria.

  • 5-hydroxy Propranolol

    Cayman Chemical

    A metabolite of propranolol.

  • Taurolidine

    Cayman Chemical

    A synthetic taurine analog with broad bactericidal and fungicidal activity; binds to the extracellular wall of bacteria, blocking adherence to epithelial and fibroblast cells; induces autophagy, apoptosis, and necrosis in human cancer cells.

  • HAMI3379

    Cayman Chemical

    A potent, selective CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 37.9 and >10, 000 nM, respectively.

  • Tonabersat

    Cayman Chemical

    An anti-migraine agent.

  • Sakuranetin

    Cayman Chemical

    A natural plant flavonoid.

  • Norgestrel

    Cayman Chemical

    A progestin that is a racemic mixture of which levonorgestrel is the biologically active component.

  • Rhodamine 123 (chloride)

    Cayman Chemical

    A membrane-permeable cationic dye that is a substrate for P-gp and is rapidly exported from cells with functional P-gp; also accumulates within mitochondria and can be used to both localize mitochondria and study their properties.

  • Deuterated Primary COX and LOX LC-MS Mixture

    Cayman Chemical

    Features Each vial contains a mixture of standards packaged in amber ampules purged with argon >1 ml provided at the concentration specified in the insert Ideally suited for use as an internal standard in mass spectrometry applications This mixture contains deuterated versions…

  • LLP-3

    Cayman Chemical

    A cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis in glioma stem cells (IC50 = 31 µM); abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.

  • Manumycin A

    Cayman Chemical

    A potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity: inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation; inhibits IKK in an number of cells types.

  • Irinotecan (hydrochloride)

    Cayman Chemical

    A derivative of the alkaloid camptothecin that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I; demonstrates a broad spectrum of antitumor activity against metastatic colorectal cancer, small cell lung cancer, and several other…

  • IKK-16 (hydrochloride)

    Cayman Chemical

    A potent inhibitor of IκB kinases (IKKs), displaying IC50 values of 200, 40, and 70 nM for IKKα, IKKβ, and IKK complex, respectively, in cell-free assays; effective in cells and in animals.

  • Chaetoglobosin A

    Cayman Chemical

    A mycotoxic cytochalasin that targets filamentous actin and demonstrates antibacterial and nematicidal effects as well as induces apoptosis in cancer cell lines.

  • Trolox

    Cayman Chemical

    A cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties; commonly used as a standard or positive control in antioxidant assays.

  • Prostaglandin D2-1-glyceryl ester

    Cayman Chemical

    2-AG has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. Incubation of 2-AG with COX-2 and specific PGH2 isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation. The…

  • Geldanamycin

    Cayman Chemical

    A benzoquinone ansamycin antibiotic which binds Hsp90 and its paralog GRP94; indirectly affects diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis; inhibits c-jun expression in HT29 cells (IC50 = 75 nM); shows promise in cancer therapy.

  • Latrunculin A

    Cayman Chemical

    A bioactive macrolide derived from sponges that binds monomeric actin, preventing actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM).

  • LPS from Escherichia coli O55:B5

    Cayman Chemical

    A form of LPS extracted from wild-type S-form E. coli serotype O55:B5; commonly used to activate TLR4 on leukocytes, eliciting inflammatory signaling in isolated cells and in vivo.

  • Anhydrotetracycline (hydrochloride)

    Cayman Chemical

    A powerful effector in both the TetR and revTetR transcriptional regulator systems, binding the Tet repressor 35-fold more strongly than Tet; does not act a general inhibitor of translation and is a poor antibiotic.

  • TCEP (hydrochloride)

    Cayman Chemical

    An odorless, selective, and water-soluble reducing agent that is commonly used in many laboratory applications; commonly used to rapidly reduce protein and peptide disulfide bonds.

  • Magnesium Chloride Stock Solution (1 M)

    Cayman Chemical

    Magnesium chloride stock solution contains filtered magnesium chloride (1 M). It is ready to use as supplied.

  • Clarithromycin

    Cayman Chemical

    A macrolide antibiotic with effectiveness against pneumococci, Streptococcus, Listeria, Corynebacterium, and Helicobacter.

  • Adenosine 5'-(?-thio)-triphosphate (lithium salt)

    Cayman Chemical

    A stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11).

  • 3-Acetyldeoxy Nivalenol

    Cayman Chemical

    A trichothecene mycotoxin that can be converted to DON in the body.

  • Vitamin B12

    Cayman Chemical

    A corrinoid vitamin with roles in brain and nervous system functioning and blood formation through regulation of DNA synthesis, cellular metabolism, fatty acid metabolism, and amino acid metabolism; serves as a cofactor in isomerase-, methyltransferase-, and dehalogenase-catalyzed reactions,…

  • GSK461364

    Cayman Chemical

    A potent, reversible, and selective inhibitor of Plk1 (Ki = 2.2 nM); dose-dependently halts cell cycling in diverse proliferating cancer cell lines and, at higher doses, triggers apoptosis; effective in vivo, inducing tumor growth inhibition or growth delay in xenograft models in mice.

  • Tyramine

    Cayman Chemical

    A trace amine that activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively); inhibits the release of norepinephrine and dopamine (IC50s = 40.6 and 119 nM, respectively).

  • Sodium Acetate Stock Solution (3 M, pH 5.2)

    Cayman Chemical

    Sodium acetate stock solution (3 M, pH 5.2) contains a concentrated solution of filtered sodium acetate buffer.

  • PBS Stock Solution (10X, pH 7.4)

    Cayman Chemical

    PBS Stock Solution (10X, pH 7.4) contains filtered concentrated PBS. It is ready to use as supplied.

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