Biologically Active Small Molecules

Compare Tool

Select up to 3 products

HomeAll Products

Cayman Chemical Biologically Active Small Molecules

1 - 32 of 5957
Sort
View
Show
  • (S)-(+)-Methoprene

    Cayman Chemical

    A widely-used insect growth regulator; acts as an activator of the juvenile hormone receptor, known as Methoprene-tolerant, or Met (Kd = 12.3 nM).

  • Resazurin (sodium salt)

    Cayman Chemical

    A blue non-fluorescent dye that is used as an oxidation-reduction indicator in cell viability assays in a variety of cells; can be reduced to the highly red-fluorescent product resorufin (excitation: 530-540 nm; emission: 585-595 nm) and used as a quantifiable detection agent in enzyme activity or…

  • 2-NBDG

    Cayman Chemical

    A fluorescently-labeled deoxyglucose analog that is used primarily to directly monitor glucose uptake by living cells and tissues; also used as a topical contrast reagent for the detection of neoplasia.

  • Nodularin

    Cayman Chemical

    A hepatotoxic monocylic pentapeptide that acts as a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively.

  • Gemfibrozil

    Cayman Chemical

    A fibrate that activates PPARα (EC50 = 193 μM) with 100% efficacy and PPARγ (EC50 = 148 μM) with 79% efficacy; lowers triglycerides and increases HDL cholesterol levels; strongly binds liver fatty acid-binding protein (Ki = 1.8 μM).

  • ONO-AE3-208

    Cayman Chemical

    An antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors; implicates EP4 signaling in immune and autoimmune responses, inflammation, and cancer.

  • N-(4-acetamidophenyl)-Indomethacin amide

    Cayman Chemical

    N-4AIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.1 and 0.625 µM, respectively. It is about 80 times less potent as an inhibitor of…

  • Dasatinib

    Cayman Chemical

    A potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family; inhibits Abl, Src, and Lck with IC50 values of 0.05, 0.5, and 0.4 nM, respectively; has potential therapeutic value in some forms of cancer and fibrotic disease.

  • Actinomycin D

    Cayman Chemical

    A cyclic polypeptide-containing anticancer antibiotic that binds to DNA and blocks transcription by interfering with RNA synthesis; ~10 nM promotes cell death in a variety of tumors.

  • Hygromycin B

    Cayman Chemical

    An antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.

  • Tamoxifen

    Cayman Chemical

    A selective estrogen receptor (ER) modulator; an ER antagonist in breast tissue, effective in treating early breast cancer; an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues.

  • Sakuranetin

    Cayman Chemical

    A natural plant flavonoid.

  • Novobiocin (sodium salt)

    Cayman Chemical

    A coumarin antibiotic that inhibits the ATPase activity of DNA gyrase, permitting relaxation of negative supercoils; also generates positively supercoiled DNA.

  • Quercetin

    Cayman Chemical

    A flavonoid compound found in the bark and rinds of many plants and fruits.

  • Polymyxin B (sulfate)

    Cayman Chemical

    A mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components; demonstrates rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumonia.

  • 3-Pyridylamide oxime

    Cayman Chemical

    A synthetic intermediate useful for pharmaceutical synthesis.

  • NCT-503

    Cayman Chemical

    A PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC50 = 2.5 µM); reduces the production of glucose-derived serine in cells and suppresses the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors.

  • Ionomycin (calcium salt)

    Cayman Chemical

    A selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to stimulate the intracellular production of cytokines.

  • LY2157299

    Cayman Chemical

    A small molecule inhibitor of the TGF-β receptor type 1 kinase (IC50 = 56 nM) that has been used to study the role of TGF-β signaling in triple negative breast cancer cells and hepatocellular carcinoma cells.

  • GSK5959

    Cayman Chemical

    A potent, selective, and cell-permeable inhibitor of the BRPF1 bromodomain (IC50 = 80 nM); disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3.3.

  • Myricetin

    Cayman Chemical

    A flavonoid compound that acts as a powerful antioxidant; inhibits TBARS formation with an IC50 value of 6.34 µM; blocks oxLDL uptake by U937-derived macrophages at 20 µM; demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit neoplastic transformation of…

  • Dihydrorhodamine 123

    Cayman Chemical

    A fluorophore that can be used as an indicator of peroxynitrite formation; neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DHR; used to investigate reactive oxygen intermediates produced by endothelial cells, eosinophils, and reactive microglia.

  • Angiotensin II (human)

    Cayman Chemical

    A peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke.

  • Captopril

    Cayman Chemical

    An ACE inhibitor (IC50 = 6.3 nM) that does not exhibit a domain preference for binding either the C- or N-terminal active sites of the somatic form of ACE; reversibly inhibits LTA4 hydrolase, inhibiting LTB4 synthesis (IC50 = 14 μM).

  • GW 4064

    Cayman Chemical

    A selective agonist of FXR (EC50 = 15 nM); displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 μM.

  • Guanabenz (hydrochloride)

    Cayman Chemical

    An α2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects; competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM).

  • Sotalol (hydrochloride)

    Cayman Chemical

    A non-selective antagonist of β-adrenergic receptors that blocks β1-, β2-, and β3-adrenoceptors with IC50 values ranging between 0.1 and 8.9 µM; also blocks outward potassium currents in myocardium, exhibiting Class III antiarrhythmic actions.

  • Tropicamide

    Cayman Chemical

    An M4 mAChR antagonist (pKi = 7.2 in chicken heart) that produces temporary mydriasis (pupil dilation; EC50 = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 µg/ml) when applied as eye drops; used to probe mAChR activity in a mouse model of fragile X syndrome.

  • Naringenin

    Cayman Chemical

    A citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 μM); demonstrates antifibrotic, lipid lowering, and insulin-like properties.

  • Amylose

    Cayman Chemical

    A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.

  • Ampicillin (sodium salt)

    Cayman Chemical

    An antibacterial antibiotic that acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria; used as a selective antibiotic for resistant bacteria.

  • L-Biopterin

    Cayman Chemical

    L-Biopterin is the oxidized form of BH4, a NOS cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs). L-Biopterin is rarely found…

Compare Tool

Select up to 3 products

Please Log In

Don't have an Account? Create one now.