Biologically Active Small Molecules

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Cayman Chemical Biologically Active Small Molecules

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  • Tigecycline

    Cayman Chemical

    A glycylcycline antibiotic with a broad spectrum of activity against many Gram-positive, Gram-negative, and anaerobic organisms, including many multidrug-resistant strains.

  • Resazurin (sodium salt)

    Cayman Chemical

    A blue non-fluorescent dye that is used as an oxidation-reduction indicator in cell viability assays in a variety of cells; can be reduced to the highly red-fluorescent product resorufin (excitation: 530-540 nm; emission: 585-595 nm) and used as a quantifiable detection agent in enzyme activity or…

  • Suberohydroxamic Acid

    Cayman Chemical

    A competitive HDAC inhibitor that inhibits HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM); causes cell differentiation, cell cycle arrest, or apoptosis.

  • D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)

    Cayman Chemical

    D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P4 increases intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release…

  • Sulfaphenazole

    Cayman Chemical

    Selective inhibitor of CYP2C9 (Ki = 0.3 μM); inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

  • Caylin-2

    Cayman Chemical

    A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~8 µM); promotes the growth of HCT116 cells ~40% at concentrations between 5-100 nM.

  • Vitamin B12

    Cayman Chemical

    A corrinoid vitamin with roles in brain and nervous system functioning and blood formation through regulation of DNA synthesis, cellular metabolism, fatty acid metabolism, and amino acid metabolism; serves as a cofactor in isomerase-, methyltransferase-, and dehalogenase-catalyzed reactions,…

  • Trolox

    Cayman Chemical

    A cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties; commonly used as a standard or positive control in antioxidant assays.

  • Aflatoxin B1

    Cayman Chemical

    Naturally occuring mycotoxin and food contaminant that induces the transversion of G to T at codon 249 of the p53 tumor suppressor gene and is a likely pathogen that causes hepatocellular carcinoma.

  • Clenbuterol (hydrochloride)

    Cayman Chemical

    A sympathomimetic β2-adrenoceptor agonist that relaxes bronchial smooth muscle and at higher doses acts as an anabolic steroid, promoting skeletal muscle protein synthesis.

  • (-)-Gallocatechin

    Cayman Chemical

    An epimer of (−)-EGC and potent antioxidant; significantly inhibits the proliferation of HCT116 and SW-480 cancer cells; inhibits the aggregation of amyloid β peptide in vitro (IC50 = 17.5 µM).

  • Fenofibric Acid

    Cayman Chemical

    A fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides; displays high affinity for L-FABP (Ki = 24 nM); exhibits EC50 values of 18 and 30 µM for murine and human PPARα, respectively, in a transactivation assay.

  • Pyocyanin

    Cayman Chemical

    Activates the aryl hydrocarbon receptor (Ki = 5.4 µM), inducing the expression of both detoxifying enzymes, resulting in pyocyanin degradation, and cytokines that facilitate the clearance of bacteria; accelerates neutrophil apoptosis, resulting in resolution of acute inflammation.

  • ML314

    Cayman Chemical

    Molecular Formula: C24H28N4O3

  • HAT Inhibitor II

    Cayman Chemical

    A cell-permeable, selective inhibitor of the HAT p300 (IC50 = 5 µM).

  • Clavulanate (potassium salt)

    Cayman Chemical

    A β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM); commonly used with other antibiotics that would be inactivated by β-lactamases.

  • Single-Use Eicosapentaenoic Acid (peroxide free)

    Cayman Chemical

    Single-use eicosapentaenoic (peroxide free) consists of 10 sealed ampules, each containing >1 ml of ethanolic solution of fatty acid at a concentration of 500 µg/ml. Peroxides were removed by silicic acid chromatography. The headspace in each ampule is purged with argon. Single-use…

  • Daidzein-d4

    Cayman Chemical

    CAS Number: 1219803-57-2 Synonyms: Isoflavone-d4 Molecular Formula: C15H6D4O4 Formula Weight: 258.3

  • Pyrazine-2-amidoxime

    Cayman Chemical

    A synthetic intermediate for pharmaceutical synthesis.

  • Bizine

    Cayman Chemical

    An LSD1 inhibitor.

  • AEM1

    Cayman Chemical

    An inhibitor of Nrf2-induced gene transcription at the antioxidant response element in cells at 1 to 10 µM; sensitizes lung carcinoma A549 cells to chemotherapeutic agents and inhibits the growth of A549 cells in vitro and in vivo in animals.

  • Amylose

    Cayman Chemical

    A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.

  • Vildagliptin

    Cayman Chemical

    An inhibitor of DPP-4 (IC50 = 3.5-34 nM); also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or FAPα; blocks the degradation of several circulating peptides, including incretins; reduces fasting and postprandial glucose levels and decreases inflammatory…

  • Zilpaterol

    Cayman Chemical

    A β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues; used as a veterinary food additive to increase lean body weight in commercial…

  • RIPA Buffer Concentrate

    Cayman Chemical

    10ml of 250 mM Tris-HCl, pH 7.6, containing 750 mM sodium chloride, 5% NP-40, 2.5% sodium deoxycholate, and 0.5% SDS

  • Ochratoxin A

    Cayman Chemical

    A mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant (Tolerable Weekly Intake = 100 ng/kg body weight per day); triggers nephropathy, induces renal adenomas, and initiates skin tumors through events involving oxidative stress,…

  • Phloxine B

    Cayman Chemical

    A red dye that can be used as an alternative to Gram staining; inhibits MRSA growth in vitro at 100 µg/ml; modulates channel activity of wild-type CFTR (Ki = 38 µM) and mutant delta F508 CFTR (Ki = 33 µM).

  • Trypsin Inhibitor (soybean)

    Cayman Chemical

    An inhibitor of serine proteases that dose-dependently inhibits trypsin from a variety of sources, as well as plasma kallikrein, thrombin, plasmin, and other serine proteases; partially inhibits chymotrypsin and neutrophil elastase.

  • 5-trans Latanoprost (free acid)

    Cayman Chemical

    An isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E); intended primarily as an analytical standard.

  • Estrone

    Cayman Chemical

    Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver. Serum…

  • TMS

    Cayman Chemical

    CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such as polyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1…

  • Probenecid

    Cayman Chemical

    A benzoic acid derivative that inhibits OAT1, OAT3, and OAT6 with Ki values of 6.3, 9.0, and 8.4 µM, respectively, as well as OAT2 with an IC50 value of 0.67 µM; enhances the renal excretion of urate while reducing the elimination of many medications; acts as an agonist of…

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