Biologically Active Small Molecules

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Cayman Chemical Biologically Active Small Molecules

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  • A synthetic analog of natural PtdIns containing C16:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

  • 2-D08

    Cayman Chemical

    An inhibitor of sumoylation.

  • Grifolic Acid

    Cayman Chemical

    A selective partial agonist of GPR120 that induces ERK activation and intracellular calcium responses in mouse enteroendocrine STC-1 cells that express GPR120 endogenously.

  • Fisetin

    Cayman Chemical

    A natural flavonol and potent antioxidant with anti-inflammatory actions; activator of sirtuin 1, inhibitor of the spleen tyrosine kinase SYK, and suppressor of CD36 gene expression.

  • Lenvatinib

    Cayman Chemical

    Lenvatinib is a potent inhibitor of VEGF-R2 and VEGF-R3 kinase activities with IC50 values of 4.0 and 5.2 nM, respectively.. It is slightly less potent against the related receptor kinases VEGF-R1, FGF-R1, PGDFR3β and Kit (IC50 values of 22, 46, 39, and 100 nM,…

  • CAY10398

    Cayman Chemical

    An inhibitor of HDAC (IC50 = 10 µM).

  • A non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects.

  • Cu-ATSM

    Cayman Chemical

    An orally bioavailable, blood-brain barrier permeable complex used in cellular imaging experiments to selectively label hypoxic tissue; improves locomotor function and survival in a transgenic ALS mouse model by delivering copper specifically to cells in the spinal cords of mice to prevent…

  • KAPA (hydrochloride)

    Cayman Chemical

    Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals. Biotin has a strong affinity for the protein avidin, a trait that has been utilized for many assay reporter applications. KAPA is a key intermediate in the biotin…

  • 11-cis Vaccenyl Acetate

    Cayman Chemical

    The male-specific mating pheromone of the fruit fly D. melanogaster; acts selectively through the Or67d odorant receptor to control mating behavior in both male and female fruit flies.

  • Dovitinib

    Cayman Chemical

    A receptor tyrosine kinase inhibitor that targets VEGF, bFGF, and PDGFβ receptors, preventing the growth and motility of various cancer cell lines and endothelial cells.

  • Lactacystin

    Cayman Chemical

    A microbial metabolite isolated from Streptomyces that is widely used as a selective inhibitor of the 20S proteasome.

  • PK 11195

    Cayman Chemical

    Binds the peripheral benzodiazepine receptor, TSPO, with selectivity and high affinity (Ki = 3.1 nM in cerebellum, 4.1 nM in spinal cord); blocks binding of typical benzodiazepines to TSPO.

  • Kanamycin A (sulfate)

    Cayman Chemical

    A broad spectrum antibiotic that alters translation by prokaryotic ribosomes, resulting in bacterial cell death; used as a selective agent to isolate transformants that are expressing a kanamycin resistance gene, usually neomycin phosphotransferase (NptII/neo).

  • Kaempferol

    Cayman Chemical

    A dietary flavonoid which has diverse physiological activities through both direct and indirect effects; directly binds ERα and ERβ, acting as an inverse agonist or agonist; acts as an antioxidant; suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.

  • Valproic Acid (sodium salt)

    Cayman Chemical

    An analog of valeric acid, long used as an anticonvulsant; inhibits Class I HDACs with an IC50 of ~2 mM; also inhibits GSK3 and depletes cellular IP3.

  • Meloxicam

    Cayman Chemical

    A COX-2-selective NSAID (IC50s = 11.8 and 143 μM for COX-2 and COX-1, in vitro); inhibits acute exudation and leukocyte migration as well as prevents bone and cartilage destruction in adjuvant arthritis animals models.

  • Kasugamycin (hydrochloride)

    Cayman Chemical

    An aminoglycosidic antibiotic that blocks the initiation of translation in bacteria.

  • Concanavalin A

    Cayman Chemical

    A plant lectin that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis; widely used in affinity chromatography purifications of various glycoproteins and cellular structures; also used to induce liver injury in…

  • Atropine

    Cayman Chemical

    Non-selective, competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5 (pKBs range from 8.9-9.8); increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine…

  • 5a-Androst-16-en-3-one

    Cayman Chemical

    A mammalian pheromone used to prime sexual behavior of sows in estrus for mating or artificial insemination; also used to study receptor-mediated odorant detection and the genetic basis for anosmias.

  • Latanoprost (free acid)-d4

    Cayman Chemical

    An internal standard for the quantification of latanoprost (free acid) by GC- or LC-MS.

  • Pepstatin A

    Cayman Chemical

    A bacterial-derived pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D; examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.

  • A fluorescent indicator of peroxynitrite formation; neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH.

  • Palmitic Acid

    Cayman Chemical

    A common 16-carbon saturated fatty acid that represents 10-20% of the normal human dietary fat intake.

  • FCCP

    Cayman Chemical

    A potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

  • Doxorubicin (hydrochloride)

    Cayman Chemical

    An anthracycline antitumor antibiotic agent that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks; inhibits nucleic acid synthesis and induces apoptosis by intercalating within DNA.

  • Resazurin (sodium salt)

    Cayman Chemical

    A blue non-fluorescent dye that is used as an oxidation-reduction indicator in cell viability assays in a variety of cells; can be reduced to the highly red-fluorescent product resorufin (excitation: 530-540 nm; emission: 585-595 nm) and used as a quantifiable detection agent in enzyme activity or…

  • Phytanic Acid

    Cayman Chemical

    Phytanic acid is a saturated 20-carbon branched-chain fatty acid which can only be derived from dietary sources. In cases of peroxisomal disorders, elevated levels of phytanic acid have been observed, and this is linked to diseases such as infantile phytanic acid storage disease and Refsum’s disease.

  • Levofloxacin

    Cayman Chemical

    A third generation fluoroquinolone with antibacterial activity; inhibits type II topoisomerases (IC50s = 8.06 and 9.81 µg/ml for DNA gyrase and topoisomerase IV, respectively).

  • Latrunculin A

    Cayman Chemical

    A bioactive macrolide derived from sponges that binds monomeric actin, preventing actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM).

  • Rhodamine 123 (chloride)

    Cayman Chemical

    A membrane-permeable cationic dye that is a substrate for P-gp and is rapidly exported from cells with functional P-gp; also accumulates within mitochondria and can be used to both localize mitochondria and study their properties.

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