Cayman Chemical

XO catalyzes the hydroxylation of hypoxanthine to xanthine and then further catalyzes the oxidation of xanthine to uric acid. When oxidizing NADH, XO generates superoxide, a powerful ROS. XO is found predominantly in the liver and intestine. However, levels of circulating XO can increase...

An unsaturated cuticular hydrocarbon that acts as a contact sex pheromone in Drosophila; may stimulate copulation either by itself at high concentrations or when combined with other alkenes; increases in Drosophila females immediately after copulation.

A synthetic intermediate useful for pharmaceutical synthesis.

A potent MAO inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively); also inhibits the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC₅₀ = 31 nM).

A FAHFA in which palmitoleic acid is esterified to 10-hydroxy stearic acid.

The active enantiomer of propranolol, a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively; widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia.

Danusertib is a pan-Aurora kinase inhibitor (IC₅₀s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC₅₀s = 25, 31, 31, and 47 nM, respectively). It exhibits anti-proliferative and pro-apoptotic activity against a panel of...

A selective inhibitor of PI3Kα with IC50 values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively.

Prominent plasma metabolite of PGF2α in the 15-hydroxy PGDH pathway.

A long-chain N-acylated HSL that functions as a quorum sensing signaling molecule in strains of S. meliloti.

A bisdeoxy derivative of coelenterazine that produces an emission peak near 400 nm following conversion by Renilla luciferase; commonly used in BRET2 protocols to evaluate protein-protein interactions.

A monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.

A mycotoxin that can have developmental, teratogenic, and carcinogenic effects in animals.

Immunogen: Full length recombinant PAD2 protein Clone: 9F7 Host: Mouse Isotype: IgG1 Species Reactivity: (+) Human PAD2 Application(s): ELISA, WB

A cell-permeable inhibitor of SCF-mediated c-kit activation, completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 µM; prevents SCF-mediated downstream phosphorylation of p44/p42 ERK.

Host: rabbit Cross Reactivity: (+) human Application: WB

Peptide sequence: 2-380 Full-length Source: recombinant C-terminal His-tagged protein expressed in E. coli Mr: 43.8 kDa

Antigen: human recombinant PCSK9 Host: rabbit Cross Reactivity: (+) human, rat, and murine PCSK9 Application(s): ICC and WB PCSK9 is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism. Gain-of-function mutations in the PCSK9 gene are associated with...

Found in the lipid A part of LPS and useful as chemical marker of endotoxins; accumulates during long-chain 3-hydroxy-acyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies, inducing oxidative stress and leading to mitochondrial bioenergetics deregulation and eventual...

A natural diterpene that increases glutathione S-transferase expression and activity in vivo; inhibits LPS-induced NO and PGE2 production (IC₅₀ = 54 and 23 μM, respectively) in RAW macrophages; blocks the proliferation of endothelial cells (IC₅₀ = 50 μM) and inhibits...

A selective muscarinic M₁ receptor agonist.

A weak FP receptor antagonist.

A potent inverse agonist of LRH-1 (IC₅₀ = 320 nM) with maximum efficacy of 40% repression; inactive at the related SF1 transcriptional activator; alters the expression of haptoglobin, SAA1, and SAA4, induces the death of MDA-MB-231 breast cancer cells, and inhibits the StAR promoter...

A melatonin metabolite first identified in rat brain that has antioxidant and free radical scavenging activities in several experimental models; may be measured in plasma as an index of melatonin synthesis and metabolism.