Cayman Chemical

A natural plant sterol that can be isolated from certain seed oils and herbs, including those used for therapeutic purposes.

An analytical reference standard categorized as a phytocannabinoid metabolite; a metabolite of CBD; intended for research and forensic applications

An irreversible inhibitor of EGFR sensitizing and T790M resistance mutations (IC₅₀s = 15-17 nM) while sparing the wild-type EGFR (IC₅₀ = 480 nM); inhibits tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg.

MLN2238 is a reversible inhibitor of the chymotrypsin-like proteolytic β5 site of the 20S proteasome (IC₅₀ = 3.4 nM; Ki = 0.93 nM in cell free assays). It inhibits the caspase-like β1 and trypsin-like β2 proteolytic sites with IC₅₀ values of 0.03 and 3.5...

A glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively); reversibly inhibits γ-glutamyl transpeptidase.

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications

A potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

A benzoylguanidine compound that selectively inhibits NHE-1 (IC₅₀s range from 0.03-3.4 µM).

A purine derivative that reversibly antagonizes aryl hydrocarbon receptor signaling (IC₅₀ = 127 nM in CD34+ cells); induces a 50-fold increase in human embryonic stem cells expressing CD34 (EC₅₀ = 120 nM) and a 17-fold increase in stem cells that retain the ability to engraft...

A stable, monomethoxylated resveratrol derivative that at 0.1-10 μM reduces neurotoxicity in SH-SY5Y cells induced by the parkinsonian mimetic 6-OHDA and scavenges DPPH radicals (IC₅₀ = 47.1 μM).

An anthelmintic spiroindole that acts as a nicotinic acetylcholine receptor antagonist, causing flaccid paralysis and expulsion of nematodes.

A phytosterol that competitively inhibits the absorption of intestinal cholesterol and decreases the transcription of genes important for cholesterol metabolism; demonstrates beneficial cardiovascular effects by reducing cholesterol for lowering the incidence of atherosclerotic plaques and...

A plant growth regulator that functions by inhibiting CYP707As (Ki = 68 nM), a family of enzymes that catabolize the plant hormone ABA, and thus, suppress gibberellin and sterol biosynthesis.

A synthetic intermediate useful for pharmaceutical synthesis.

A monotetrazolium salt used as an indicator dye; reduced to an insoluble formazan that is used as a vital dye or indicator of cellular redox activity; commonly used to measure the respiratory activity of microorganisms in a variety of contexts.

A form of EPA with an ω-terminal alkyne that can be used in click chemistry linking reactions to tag EPA with fluorescent or biotinylated labels for analysis of its metabolism and biological activity.

Antigen: human PPARg1 amino acids 82-101 (amino acids 110-129 of PPARg2) Host: rabbit Cross Reactivity: (+) human and mouse PPARg1 and PPARg2 Application(s): WB PPARg is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of...

Antigen: human MAGL amino acids 1-14 Host: rabbit Cross Reactivity: (+) human, bovine, mouse, and rat MAGL Application(s): IHC (formalin-fixed paraffin-embedded tissue) and WB

An internal standard for the quantification of (±)-nicotine by GC- or LC-MS.

A food contaminant produced by Aspergillus that is associated with toxicity and hepatocarcinogenicity in human and animal populations.

A natural flavonol aglycone that has antioxidant activity and inhibits xanthine oxidase (IC₅₀ = 0.40 µM); competitively inhibits MATE1, Ki = 0.32 µM); potentiates the neurological actions of nerve growth factor, diminishes the cardiotoxic impact of doxorubicin, and can have...

An ionophorous antibiotic that preferentially forms complexes with monovalent cations for lipid-soluble transport across membrane bilayers; active against Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 µg/ml), of P. falciparum and Coccicdium protozoa,...

Host: mouse, clone 5F6 Isotype: IgG2b Cross Reactivity: (+) human and mouse MPO Application(s): IF

A cell-permeable inhibitor of ROCK (Ki = 150 nM); less effectively inhibits PKA (Ki = 2.2 μM).