Cayman Chemical

A hybrid molecule patterned after N-arachidonoyl serotonin; while saturated 11- or 12-carbon fatty acids linked to serotonin potently inhibit capsaicin-induced TRPV1 channel activation (IC₅₀ = 0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine...

Induces protein expression where the gene is under the control of the lac operator by triggering transcription of the lac operon in cloning procedures.

Antigen: synthetic peptide corresponding to a mixture of mouse IRAK-4 amino acids 38-54 and 120-136 Host: rabbit Cross Reactivity: (+) human and mouse IRAK-4 Application(s): IP and WB IRAK-4 may act as an upstream activator of IRAK-1 and is important for LPS activation of TLRs. Mice lacking IRAK4...

An anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC₅₀ = 5.3 μM), thus inhibiting cell proliferation; human HIV-1 integrase (IC₅₀ = 3.8 μM); exported from cells in an ATP- and glutathione-dependent manner by MRP1.

A selective and reversible inhibitor of IKK2 (IC50 = 3- 12 μM) that displays >10-fold selectivity over 28 other kinases; attenuates NF-κB-mediated gene expression in synovial fibroblasts, smooth muscle cells, and astrocytes.

An apoptosis inducer that inhibits the mitochondrial F1FO ATPase (Ki = 4-5 µM); selectively kills transformed glial cells without significantly affecting untransformed cells.

A prodrug of 5-aminosalicylic acid that is used to treat inflammatory bowel disease and rheumatoid arthritis because of its ability to induce T lymphocyte apoptosis, modulate inflammatory mediators from both COX/5-LO pathways and NF-κB signaling pathways, attenuate transcription of...

An O-methylated isoflavone with weak estrogenic activity (IC₅₀ = 3.94 μM) that has been used in research related phytoestrogen therapeutic activity applied to bone formation, cardiovascular disease, estrogen-dependent cancer, and Alzheimer’s disease.

Antigen: recombinant human ANGPTL3 Host: mouse, clone Kairos-37 Cross Reactivity: (+) human ANGPTL3; (−) human ANGPTL isoforms 1, 2, 4, 6, and 7 Application(s): ELISA and WB ANGPTL3 regulates angiogenesis and also directly regulates lipid, glucose, and energy metabolism.

A natural ITC that has diverse effects on intracellular signaling, gene expression, and cell cycling in different types of cells in culture; demonstrates neuroprotective effects in a mouse model of Parkinson’s disease.

A process-related impurity commonly found in the bulk synthesis of candesartan cilexetil.

A selective antagonist of S1P binding to the S1P3 receptor; blocks calcium increase in HeLa cells by about 40% at 10 µM.

An endogenous CB neurotransmitter that binds to both CB1 and CB2 receptors.

Molecular Formula C₂₁H₂₃ClN₂O₂ • HCl Formula Weight 407.3

An inhibitor of IDO (IC₅₀ = 7 µM) that is effective in vivo; prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice; causes regression of tumors and prolongs survival when used in combination with chemotherapy.

A LPA analog containing stearyl alcohol at the sn-1 position; exhibits platelet aggregating activity with an EC50 value of 9 nM versus an EC50 value of 177 nM for 1-octadecanoyl LPA.

cis-4,10-13,16-Docosatetraenoic acid methyl ester is a long chain PUFA. It is a minor fatty acid component of rat testis lipids. The methyl ester is a neutral, more lipophilic form of the free acid.

An inhibitor of RET (IC₅₀ = 0.88 µM), FLT3 (Ki = 0.12 µM), KDR, c-Abl, and c-Kit; demonstrates antiproliferative activity in various cancer cells, including those with RET or FLT3 mutations.

A selective inhibitor of Plks (IC₅₀s = 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively); inhibits the proliferation of various cancer cell lines and prevents tumor growth in several human cancer cell xenograft models.

The stabilized ethyl ester form of DHA; dietary intake enhances maze-learning in mice; in rats it increases fatty acid oxidation enzymes and in humans with peroxisomal disorders it improves vision, liver function, and muscle tone; may directly modulate the actions of enzymes involved in fatty acid...

A synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections; inhibits the replication of human CMV with an IC₅₀ value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig.

An inducer of reactivation of mutant p53 in cancer cells that induces growth inhibition, cell-cycle arrest, and apoptosis.

15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of DGLA. It is an inhibitor of 5-LO in human PMNL with an IC₅₀ value of 4.6 µM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.

Cayman’s Cortisol ELISA is a competitive assay that provides accurate measurements of cortisol within the range of 6.6-4,000 pg/ml.