Cayman Chemical

An internal standard for the quantification of AEA by GC- or LC-mass spectrometry.

An HMG-CoA reductase inhibitor that is effective in treating hypercholesterolemia and certain dyslipidemias; reduces the production of LDL as well as inhibiting cholesterol synthesis; metabolized by CYP3A4, prodrug several metabolites that are important in the therapeutic actions attributed to...

Immunogen: synthetic peptide from the C-terminal region of murine LDLR Host: rabbit Species Reactivity: (+) human, mouse, and rat LDLR Application(s): ICC and WB The LDLRs are cell surface glycoproteins that scavenge LDL from the blood and regulate plasma LDL cholesterol.

An inactive enantiomer of (−)-Blebbistatin.

A dihydroxy fatty acid synthesized by 15-LO from 5(S)-HETE; chemotactic for eosinophils (ED50 = 0.3 µM).

A broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin; inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC₅₀ = 10...

A FAHFA in which oleic acid occurs at the 12-position on hydroxy stearic acid.

Lipases perform essential roles in the digestion, transportation, and processing of dietary lipids by controlling the clearance of triglyceride-rich lipoproteins from the circulation. Manipulating lipolysis has therapeutic potential in the metabolic disorders frequently associated with obesity....

A symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response (IC₅₀ = 5 nM in a cell-reporter assay); passes through the blood-brain barrier and significantly enhances learning and memory in mice and rats.

A FAHFA in which palmitic acid occurs at the 12-position on hydroxy stearic acid; present at 2- to 3-fold higher levels in adipose tissue of AG4OX mice compared to wild type and in fasted wild-type mice compared to fed; levels are reduced upon high-fat diet-induced obesity in insulin-resistant mice.

A metabolite of the saturated fatty acid palmitic acid (16:0) that has been hydroxylated on its terminal (ω) carbon; produced by ω-hydroxylation of palmitic acid by cytochrome P450 in both plants and animals; a common component of cutin in plants.

3-Pyrimidin-2-yl-2-pyrimidin-2-ylmethyl-propionic acid is a synthetic intermediate useful for pharmaceutical synthesis.

Antigen: human recombinant sPLA2 (type IIA) Host: mouse Cross-Reactivity: (+) human sPLA2 (type IIA); (−) bee venom sPLA2 (type III) and human sPLA2 (type V) Application(s): WB, IHC and IP; other applications not tested Isotype: IgG1 Clone designation: SCACC353

A potent inhibitor of Aurora kinases (IC₅₀s = 15, 25 and 19 nM for Aurora A, B, and C, respectively); also inhibits FLT3 as well as the constitutively active FLT3-ITD form (IC₅₀s = 1.2 and 4.9 nM, respectively); orally bioavailable, inhibiting the growth of SW620 colon...

Elaidic acid is the 9-trans isomer of oleic acid. It is a monounsaturated trans-fatty acid which can be found in partially hydrogenated cooking oils. In human platelets incubated with arachidonic acid, elaidic acid inhibits HHT and HETE formation while inducing prostaglandin and thromboxane...

Pinolenic acid methyl ester is a neutral, more lipophilic form of the free acid.

A reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities; rapidly and transiently increases local blood flow.

A cell permeable inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 2.5 nM) that demonstrates 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110α, β, and γ, respectively); blocks constitutive PI3K...

An affinity probe with a hydrophilic spacer that allows progesterone to be detected or immobilized using the biotin ligand.

An internal standard for the quantification of PGE2 by GC- or LC-MS.

An irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.

A mammalian pheromone used to prime sexual behavior of sows in estrus for mating or artificial insemination; also used to study receptor-mediated odorant detection and the genetic basis for anosmias.

A cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis in glioma stem cells (IC₅₀ = 31 µM); abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.

An analog of retinoic acid that potently and selectively activates retinoic acid receptors (EC₅₀s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively); used to study RAR action in epidermal cell proliferation, embryogenesis, and stem cell differentiation.