Cayman Chemical

A selective RORα and RORγ agonist that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 µM without effect at the related LXR and FXR receptors; stabilizes p53 and induces apoptosis in HepG2 cancer cells.

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 52.4 kDa

Source: recombinant enzyme expressed in E. coli Mr: 74.5 kDa As part of a dimer, this transcription factors binds with p65 to form NF-κB, which is responsible for regulating the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules

A potent and specific small molecule inhibitor of PORCN (IC₅₀ = 0.4 nM); greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity; orally bioavailable in mice.

PAPA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 15 minutes and 77 minutes at 37°C and 22-25°C, respectively, pH 7.4, to liberate 2 moles of NO per mole of parent compound.

An intermediate produced from vitamin D2 by cytochrome P450 isoforms in vertebrates; subsequently metabolized to 1,25-dihydroxy vitamin D2, which is an agonist for the vitamin D receptor.

8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful prodrugs. In general, the...

The first identified small molecule inhibitor of Shh signaling that acts upstream of Smo, binding directly to Shh (Kd = 3.1 μM); represses Gli-mediated transcription in primary human keratinocytes and synthetic human skin in a concentration-dependent manner.

A congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group that potentiates the activity of other endocannabinoids, including 2-AG; this “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to rapidly reduce...

A fluoroquinolone antibiotic that is administered either orally or parenterally.

A tetracyclic antidepressant that inhibits norepinephrine and serotonin reuptake, binding the respective transporters with Kd values of 16 and 58 nM; acts as either an antagonist or inverse agonist at 5-HT2A, 2B, 2C, 3, 6, 7 (Kis = 1 and 2 nM for 5-HT2A and 5-HT2C), D2, 3, 4 (Kd = 160 nM for D2),...

Structurally mimics 2-OG and chelates zinc; blocks the activity of 2-OG oxygenases (certain lysine demethylases and hydroxylases); inhibits several Jumonji domain-containing lysine demethylases at low micromolar concentrations and prolyl hydroxlase 1 (IC50 = 1.5 µM).

A fluorescent calcium indicator commonly used in FC and cell-based experiments to detect changes in intracellular calcium levels.

A selective FFAR4 antagonist (pIC₅₀s = 7.1 versus < 4.6 for human FFAR4 and FFAR1 receptors, respectively) that inhibits intracellular calcium accumulation induced by either linoleic acid or an FFAR4 agonist.

Commonly used as a pH indicator, a color marker in agarose or polyacrylamide gel electrophoresis, and a dye to detect proteins and nucleic acids (absorbance at 610 nm), particularly when staining living tissues.

A synthetic intermediate useful for pharmaceutical synthesis.

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr386 of human MEK 1; expected to react with bovine, canine, chicken, mouse, non-human primates, and Xenopus MEK1 Host: rabbit Cross Reactivity: (+) rat MEK1 Application(s): WB MEK1 is an integral component of the MAPK...

Antigen: CYPYDVPDYA Host: rabbit Application: WB utilized, but usually ranges from 3 to 5 kDa. Cayman Chemical’s HA polyclonal antibody will recognize proteins expressed with both N-terminal and C-terminal HA tags.

An internal standard for the quantification of PAF C-18 by GC- or LC-MS.

A neuroexcitatory amino acid that functions as a NMDA and metabotropic glutamate receptor agonist; used to induce brain lesions in animal models of cognitive dysfunction.

A central second messenger in cell signaling, propagating signals from receptors to downstream pathways; generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors.

Antigen: recombinant mouse ANGPTL3 Host: rat, clone Kairos3-1541 Cross Reactivity: (+) mouse ANGPTL3; (−) mouse ANGPTL4 and human ANGPTL3 Application(s): ELISA and WB ANGPTL3 regulates angiogenesis and also directly regulates lipid, glucose, and energy metabolism.

5-ASA is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn’s disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak,...

An intermediate for the synthesis of carbohydrates.