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A synthetic intermediate useful for pharmaceutical synthesis.
An inositol-1,4,5-trisphosphate receptor antagonist; completely blocks the increase in intracellular calcium in vascular smooth muscle cells at a concentration of 25 µM.
(±)11-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets....
CAS Number: 1000998-59-3 Molecular Formula: C22H21ClN2O6 Formula Weight: 444.9
For direct immunofluorescent detection of HA fusion proteins
An irreversible inhibitor of glandular and plasma kallikreins that has been shown to prevent apolipoprotein proteolysis in dextran sulfate-precipitated human plasma LDL and to inhibit serum atrial natriuretic peptide cleavage.
A potent agonist at four of the sphingosine-1-phosphate (S1P) receptors with IC50 values of 0.2-6 nM.
A SERM that impairs the activation of ERs by 17β-estradiol; potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively); enhances the release of gonadotropin-releasing hormone, culminating in ovulation.
Source: 50 µg of recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 39 kDa NcoR2 is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. HDACs can mediate nuclear receptor functions by forming co-repressor complexes with...
A lipophilic analog of 17-phenyl trinor PGF2α, a potent agonist for the FP receptor.
A potent, selective antagonist of σ1 receptors (Ki = 17 nM) that weakly binds σ2 receptors (Ki = 9,300 nM); dose-dependently inhibits neuropathic pain in several animal models, including formalin-induced nociception and capsaicin-induced mechanical hypersensitivity.
An analog of PtdIns-(3,4,5)-P3 that is resistant to hydrolysis by PTEN; 5-fold reduced affinity for the specific PtdIns(3,4,5)-P3-binding protein Grp1 and increases sodium transport in A6 cell monolayers.
Contains a mixture of C12:0 diglyceride racemates with acyl groups attached at either α, α- or α, β-positions; used for the investigation of biological and physicochemical relationships of membrane glycerides and employed as an industrial surfactant and building block for...
Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser831 of GluR1 Host: rabbit Cross Reactivity: (+) rat GluR1 Application(s): WB The AMPAR are comprised of four distinct GluR subunits designated (GluR1-4), which play key roles in virtually all excitatory...
A 2,6-disubstituted purine derivative that causes dedifferentiation of cultured myoblasts into confluent stem cell progenitors.
An orally active inhibitor of PI3Kg that suppresses joint inflammation in mouse models of rheumatoid arthritis; inhibits human recombinant PI3Kg, a, b, and d in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.
A chemoselective probe for detecting sulfenylated proteins in intact cells using click chemistry.
COX-1 and COX-2 catalyze the production of the PG and TX precursor PGH2. COX-2 is primarily responsible for the biosynthesis of PGs under acute inflammatory conditions. The COX-2 (human recombinant) Inhibitor Screening Assay measures PGF2α that is produced by SnCl2 reduction of COX-2-derived...
5-Chloroesorcinol dimethyl ether is a synthetic intermediate useful for pharmaceutical synthesis.
Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of COX enzymes. It can therefore serve as a reducing co-substrate for COX reactions. The one-electron oxidation...
A nitrogen mustard alkylating agent used as a chemotherapeutic agent against advanced transitional cell carcinoma; serves as a prodrug that is metabolized to its active DNA alkylating form, isophosphoramide mustard.
Immunogen: Recombinant human vimentin protein Host: Mouse Species Reactivity: (+) Human vimentin Cross Reactivity: (+) Citrullinated vimentin Applications: ELISA and WB
Antigen: synthetic peptide corresponding to mouse caspase-14 amino acids 2-18 Host: mouse Cross Reactivity: (+) human and mouse caspase-14 Application(s): FC (intracellular) and WB Caspase-14 has a conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been...
The first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ≥ 10 µM) and xanthine oxidase (IC50 = 3.5 µM).