Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser831 of GluR1
Host: rabbit
Cross Reactivity: (+) rat GluR1
Application(s): WB
The AMPAR are comprised of four distinct GluR subunits designated (GluR1-4), which play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is potentiated by phosphorylation at Ser831 which has been shown to be mediated by either PKC or CaM kinase II. Phosphorylation of this site has also been linked to synaptic plasticity as well as learning and memory.