Cayman Chemical

A 19-carbon saturated fatty acid that inhibits HL-60 cancer cell proliferation with an IC₅₀ value of 68 μM.

A potent inhibitor of Aurora A kinase (IC50 = 31 nM); does not inhibit Aurora B kinase at doses up to 100 μM; inhibits the proliferation of HCT116, Colo205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).

UNC669 is an inhibitor of the MBT domain of L3MBTL1 with an IC₅₀ value of 6 µM. It is 5- and 10-fold selective for L3MBTL1 over the related proteins L3MBTL3 and L3MBTL4.

An antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC₅₀ = 100 nM); inhibits ADP-induced platelet aggregation ex vivo; shown to be beneficial in the prevention of vascular ischemic events for patients without...

A selective inhibitor of mPGES?-1, blocking the synthesis of PGE2 but not PGF2α in A549 cells stimulated with IL-1β (IC₅₀s = 2.9 and >100 µM, respectively); absorbed through enterocytes, metabolically stable in human and rat microsome preparations, and bioavailable in...

A tetracyclic antidepressant that inhibits norepinephrine reuptake via the norepinephrine transporter (KD = 11.1 nM); inhibits serotonin 5-HT2A receptors (Ki = 51 nM) and binds the histamine H1 and α1-adrenergic receptors (KD = 2 and 90 nM, respectively.

A synthetic thyroid hormone mimetic that lowers total and LDL cholesterol up to 40% when administered to humans at a dose of 50-200 µg once daily for 14 days; stimulates cholesterol catabolism to bile acids without affecting cholesterol synthesis.

An internal standard for the quantification of ALA by GC- or LC-MS.

Lauric acid ethyl ester is a more lipophilic and less toxic form of the free acid. It is one of the medium-chain fatty acid ethyl esters that is released during the anaerobic fermentation of Saccharomyces cerevisiae along with the free acid.

A polymethoxylated flavone isolated from citrus peels; inhibits signaling in cancer cells, reducing ERK signaling in T47D breast cancer cells (IC50 ~3 μM).

A cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC₅₀ = 10 nM); not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks; induces G1-cell cycle arrest and autophagy; inhibits tumor growth in a xenograft model of renal cell carcinoma.

An internal standard for the quantification of 17β-estradiol by GC- or LC-MS.

6-Bromoisoquinoline is a synthetic intermediate useful for pharmaceutical synthesis.

A renal natriuretic peptide that regulates sodium and water reabsorption in the kidney; has pharmacological effects on renal, cardiovascular, and pulmonary parameters in animals.

Cayman's OX1R Reporter Assay Kit consists of a 96-well plate coated with a transfection complex containing DNA constructs for OX1R, a recombinant G-protein, and a cAMP response element regulated Secreted Alkaline Phosphatase (SEAP) reporter (OX1R Reverse Transfection Strip Plate). Cells grown on...

A prodrug of the α1-adrenergic receptor agonist, DMAE (Kis= 2, 6.9, and 1.7 µM for α1A, α1B, α1D, respectively); 1-5 mg/kg produces a dose-related increase in mean arterial pressure in normotensive rats and improves the orthostatic index in an experimental model of...

A hexamer of N-acetylglucosamine that functions as an elicitor in plants, inducing the expression of chitinases; a substrate of lysozyme; binds LysM domains on certain proteins, including an endopeptidase of T. thermophilus.

A brominated form of UTP that is used to label RNA during transcription; BrUTP in newly-transcribed RNA is evaluated immunologically with antibodies.

A tetraline that inhibits monoamine transporters with selectivity for the serotonin transporter (IC₅₀s = 70, 520, and 720 nM for the serotonin, dopamine, and norepinephrine transporters, respectively).

A cytotoxin that inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion.

An affinity probe which allows PGE2 to be detected or immobilized using the biotin ligand; the PEG11 moiety serves as a hydrophilic spacer.

A high-affinity fluorescent calcium indicator (Kd = 115 nM for calcium) that is ideal for monitoring low levels of calcium, as are found in resting cells; may be used to buffer intracellular calcium transients.

A cell-permeable, stable free radical that is commonly used to evaluate the ability of compounds to act as free radical scavengers or hydrogen donors and to measure the antioxidant activity of tissue extracts; followed by color change from purple (absorbance at 515-528 nm) to yellow.

11-dehydro TXB2-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 11-dehydro TXB2 by GC- or LC-mass spectrometry. 11-dehydro TXB2 is a urinary metabolite of TXB2 and TXA2.