Cayman Chemical

CAY10494 is a synthetic intermediate useful for pharmaceutical synthesis.

A trace amine that activates TAAR1 (EC₅₀s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively); inhibits the release of norepinephrine and dopamine (IC₅₀s = 40.6 and 119 nM, respectively).

A synthetic analog of natural PtdIns containing C6:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as that of the natural compound.

A 19-carbon saturated fatty acid that inhibits HL-60 cancer cell proliferation with an IC₅₀ value of 68 μM.

A potent inhibitor of Aurora A kinase (IC50 = 31 nM); does not inhibit Aurora B kinase at doses up to 100 μM; inhibits the proliferation of HCT116, Colo205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).

UNC669 is an inhibitor of the MBT domain of L3MBTL1 with an IC₅₀ value of 6 µM. It is 5- and 10-fold selective for L3MBTL1 over the related proteins L3MBTL3 and L3MBTL4.

An antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC₅₀ = 100 nM); inhibits ADP-induced platelet aggregation ex vivo; shown to be beneficial in the prevention of vascular ischemic events for patients without...

A selective inhibitor of mPGES?-1, blocking the synthesis of PGE2 but not PGF2α in A549 cells stimulated with IL-1β (IC₅₀s = 2.9 and >100 µM, respectively); absorbed through enterocytes, metabolically stable in human and rat microsome preparations, and bioavailable in...

A tetracyclic antidepressant that inhibits norepinephrine reuptake via the norepinephrine transporter (KD = 11.1 nM); inhibits serotonin 5-HT2A receptors (Ki = 51 nM) and binds the histamine H1 and α1-adrenergic receptors (KD = 2 and 90 nM, respectively.

A synthetic thyroid hormone mimetic that lowers total and LDL cholesterol up to 40% when administered to humans at a dose of 50-200 µg once daily for 14 days; stimulates cholesterol catabolism to bile acids without affecting cholesterol synthesis.

An internal standard for the quantification of ALA by GC- or LC-MS.

Lauric acid ethyl ester is a more lipophilic and less toxic form of the free acid. It is one of the medium-chain fatty acid ethyl esters that is released during the anaerobic fermentation of Saccharomyces cerevisiae along with the free acid.

A polymethoxylated flavone isolated from citrus peels; inhibits signaling in cancer cells, reducing ERK signaling in T47D breast cancer cells (IC50 ~3 μM).

A cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC₅₀ = 10 nM); not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks; induces G1-cell cycle arrest and autophagy; inhibits tumor growth in a xenograft model of renal cell carcinoma.

An internal standard for the quantification of 17β-estradiol by GC- or LC-MS.

6-Bromoisoquinoline is a synthetic intermediate useful for pharmaceutical synthesis.

A renal natriuretic peptide that regulates sodium and water reabsorption in the kidney; has pharmacological effects on renal, cardiovascular, and pulmonary parameters in animals.

Cayman's OX1R Reporter Assay Kit consists of a 96-well plate coated with a transfection complex containing DNA constructs for OX1R, a recombinant G-protein, and a cAMP response element regulated Secreted Alkaline Phosphatase (SEAP) reporter (OX1R Reverse Transfection Strip Plate). Cells grown on...

A prodrug of the α1-adrenergic receptor agonist, DMAE (Kis= 2, 6.9, and 1.7 µM for α1A, α1B, α1D, respectively); 1-5 mg/kg produces a dose-related increase in mean arterial pressure in normotensive rats and improves the orthostatic index in an experimental model of...

A hexamer of N-acetylglucosamine that functions as an elicitor in plants, inducing the expression of chitinases; a substrate of lysozyme; binds LysM domains on certain proteins, including an endopeptidase of T. thermophilus.

A brominated form of UTP that is used to label RNA during transcription; BrUTP in newly-transcribed RNA is evaluated immunologically with antibodies.

A tetraline that inhibits monoamine transporters with selectivity for the serotonin transporter (IC₅₀s = 70, 520, and 720 nM for the serotonin, dopamine, and norepinephrine transporters, respectively).

A cytotoxin that inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion.

An affinity probe which allows PGE2 to be detected or immobilized using the biotin ligand; the PEG11 moiety serves as a hydrophilic spacer.