Cayman Chemical

A cell-permeable, stable free radical that is commonly used to evaluate the ability of compounds to act as free radical scavengers or hydrogen donors and to measure the antioxidant activity of tissue extracts; followed by color change from purple (absorbance at 515-528 nm) to yellow.

11-dehydro TXB2-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 11-dehydro TXB2 by GC- or LC-mass spectrometry. 11-dehydro TXB2 is a urinary metabolite of TXB2 and TXA2.

The PGD2 Quant-PAK has been designed for the convenient, precise quantification of PGD2 by GC- or LC-MS. It includes a 50 µg vial of PGD2-d4 and a precisely weighed vial of unlabeled PGD2, with the precise weight indicated on the vial. This unlabeled PGD2can be used to quantify the PGD2-d4...

1-Oleoyl LPA is a species of LPA containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase. Hydrolysis of the fatty acid...

The 4-oxo derivative of TEMPO; possible uses as a spin trap, in hydrogen transfer experiments, and as a polarizing agent in dynamic nuclear polarization NMR spectroscopy.

A cysteine sulfoxide constituent of garlic that exhibits anti-cancer, anti-microbial, anti-hypertensive, cardioprotective, and anti-oxidant activities; inhibits squalene monooxygenase (IC₅₀ = 120 μM), a rate-limiting step in the downstream pathway of cholesterol biosynthesis.

A gliotoxic analog of the excitatory neurotransmitter glutamate that competitively inhibits glutamine synthetase (Ki = 209 µM); actively accumulates in glial cells and inhibits the glutamate transporter with a (Ki = 192 µM).

A thymidine analog used to label DNA newly synthesized during the S phase of the cell cycle.

Antigen: human BLT1 receptor amino acids 331-352 (ALEPGPSESLTASSPLKLNELN) Host: rabbit Cross Reactivity: (+) human and bovine BLT1 receptor; (−) mouse BLT1 receptor Applications: CF, FC, IHC (formalin-fixed paraffin-embedded tissue), and WB The human BLT1 receptor is a GPCR that mediates the...

The NF-κB/Rel family of transcription factors is comprised of several structurally-related proteins that form homodimers and heterodimers and include p50/p105, p52/p100, RelA (p65), and c-Rel/NF-κB. Acting as dimers, these transcription factors bind to κB sites on DNA, thereby...

This goat anti-mouse IgG HRP is used as the 'secondary antibody' for western blotting or ELISA where the primary antibody was generated in mice. This peroxidase conjugated secondary antibody is suitable for western blotting when employing detection by commercially available chemiluminescence...

A form of glutamate linked to a photoprotecting that upon exposure to light (300 - 380 nm excitation) releases L-glutamate within submicroseconds; used to investigate the mechanisms of fast synaptic glutamate receptors in situ.

13(S)-HODE is the LO metabolite of linoleic acid. 13(S)-HODE modulates the PAF, LTB4, and fMLP-induced calcium influx in human PMNL. The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or...

A cyanogenic glucoside that is the precursor to amygdalin and can be degraded to hydrogen cyanide, glucose, and benzaldehyde; possesses inhibitory effects on plant growth and inhibits DNA polymerase β (IC₅₀ = 98 µM).

A redox-sensitive tetrazolium salt used primarily to detect metabolic activity in microorganisms; readily taken up by living cells and reduced by respiratory activity to produce a red fluorescent, water-insoluble formazan crystal (absorption maximum at 450 nm).

Used to detect URA3 gene expression in yeast molecular genetic constructs.

A natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC50 = 3 μg/ml); used for the analysis of mRNA stability; inhibits endothelial cell adhesion (IC50 induced angiogenesis in mice by inhibiting Hsp27 interactions with cytoskeletal elements.

A derivative of GABA that acts as an antagonist of GABAA receptors (Ki = 74-150 nM); elicits seizures when administered intravenously in mice; effective against GABAA receptor isoforms from mice, rats, and humans.

An anthelmintic that is effective against F. hepatica, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite; demonstrates a protective role during various cellular stresses in yeast and mammalian cells.

An analog of geldanamycin which has potent in vivo activity and reduced toxicity; has diverse anti-tumor actions; promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).

A linear imidazoquinazoline that potently and selectively inhibits the tyrosine kinase activity of EGFR (IC₅₀ = 8 pM).

Cayman’s TrxR Assay provides a convenient method for quantifying mammalian TrxR activity from tissue homogenates and cell lysates in a colorimetric 96-well plate format. In this assay, TrxR uses NADPH to reduce DTNB to 5-thio-2-nitrobenzoic acid (TNB) which absorbs strongly at 405-414 nm....

Antigen: a peptide within the region of amino acids 1-50 of human RORγ Host: rabbit Cross Reactivity: (+) chimpanzee and human RORγ; predicted to react with bovine, canine, mouse, and rat RORγ Application(s): IHC and WB

A specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis and induces protein unfolding; impairs the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, IGF-IR, and ALK; radiosensitizes glioma and pancreatic adenocarcinoma cells to...