Cayman Chemical

A specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis and induces protein unfolding; impairs the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, IGF-IR, and ALK; radiosensitizes glioma and pancreatic adenocarcinoma cells to...

A selective PAF receptor antagonist (IC₅₀ = 37.6 μM); increases lipolysis and inhibits adipogenesis in adipocytes via the activated AMPK pathway.

A potent, reversible broad spectrum inhibitor of zinc-containing proteases; inhibits thermolysin and elastase, both with Ki values of 20 nM; inhibits MMP-1, -2, -7, -8, -9, -12, -13, -14, -16, and -26 with Ki or IC50 values between 0.1 and 10 nM; inhibits ADAM9, ADAM10, ADAM12, and ADAM17 at...

An intermediate compound produced by the dephosphorylation of inositol-tetrakisphosphate forms; biological roles remain to be determined.

An inhibitor of Ras-induced malignant transformation that prevents anchorage-independent growth of oncogene transformed fibroblasts; blocks Ras/Rac-induced membrane ruffling in REF-52 fibroblasts (5-25 µM) with little effect on Ras-induced ERK and JNK kinase activity.

The active metabolite of irinotecan that potently inhibits DNA topoisomerase I; more cytotoxic to HT-29 colon cancer cells (IC₅₀ = 8.8 nM) compared to irinotecan (IC₅₀ > 100 nM).

A synthetic analog of natural PtdIns featuring C16:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

A stable salt of SAM that is included in nutritional supplements for oral use; reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity.

A bioactive sterol that can affect cholesterol homeostasis, membrane properties and cell survival; inhibits CYP7A1 with an IC₅₀ = ~ 1 µM; can be used as a standard in the determination of cholesterol derivatives by GC-MS or HPLC.

A homolog of EPEA, characterized by the addition of an (R)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.

A selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity to muscarinic receptors (Ki = 16 nM) and is a positive allosteric modulator of P2X7 receptors; inhibits histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.

A retinoic acid receptor agonist that is selective for RARα (Kd = 62 nM; AC50 = 1.46 nM) compared to RARβ (Kd = 280 nM; AC50 = 6.87 nM) and RARγ (Kd = 816 nM; AC50 = 148.7 nM); induces human promyelocytic leukemia HL-60 cell differentiation (ED₅₀ = 0.79 nM) and exhibits...

Inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM; potent inhibitor of NO and PGE2 biosynthesis by reducing iNOS and COX-2 expression.

A sesquiterpene lactone which protects against cerebral edema, decreases cortical infarct volume, and reduces cerebral ischemic damage; at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions; increases the levels and activities of several...

YC-1 is an NO-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC₅₀ values of 11.7-14.6 and 57.3-59.3 µM, respectively. In the absence of NO or CO, 200 µM YC-1 increases the...

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of HIV-1 reverse transcriptase. Dapivirine, a diarylpyrimidine derivative of the potent NNRTI efavirenz (Item No. 14412), inhibits HIV-1 reverse transcriptase with an IC₅₀ value...

A resveratrol analog that exhibits potent anticancer properties; induces apoptosis in BJAB Burkitt-like lymphoma cells with an ED50 value of 25 µM.

Contains selected eicosanoids produced by the metabolism of prostaglandins; designed for direct use in LC-MS applications.

Formed by the condensation of oxaloacetate with glyoxylate; inhibits aconitase activity at 1 mM, which interferes with IRP1 binding and decreases glutamate secretion in lens and retinal pigment epithelial cells.

Substance P is a bioactive 11-amino acid peptide first isolated in 1931 from brain and intestine. The peptide is involved in many physiological processes including pain modulation, smooth muscle contraction, blood pressure control, kidney function, and water homeostasis. Substance P is widely...

?8-Hydroxy-2'-deoxyguanosine is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a marker of oxidative stress in biological systems.

A protein kinase C inhibitor with structural similarity to staurosporine; inhibits PKCα (93% kinase activity inhibited at 1 μM ), PDK1 (IC50 =3.8 μM), S6K1, MAPKAP-K1, RSK2 and MSK1.

Immunogen: human GPR55 amino acids 207-219 Host: rabbit Cross Reactivity: (+) human, bovine, and mouse (Neuro-2a cells) GPR55 Application(s): FC, IF, and WB GPR55 is a GPCR identified as a novel cannabinoid receptor that binds THC, anandamide, methanandamide, JWH015, and many other cannabinoid...

A fluorescent, membrane-permeable biarsenical compound that binds covalently to tetracysteine sequences, which are engineered into target proteins.