Cayman Chemical

A natural sesquiterpene alkaloid that inhibits AChE in rat cortex in vitro (IC₅₀ = 82 nM) and displays oral AChE inhibitory activity in animals.

Prostaglandin F2α-biotin (PGF2α-biotin) is an affinity probe which allows PGF2α to be detected through an interaction with the biotin ligand. PGF2α-biotin was designed to allow PGF2α to be detected in complexes with transmembrane receptors and/or nucleic acid or protein...

Antigen: recombinant mouse FTO Host: rat, clone FT 342-1 Isotype: IgG2ak Cross Reactivity: (+) mouse and rat FTO; (−) human FTO Application(s): ELISA and WB FTO is associated with type 2 diabetes and positively correlated with other symptoms of the metabolic syndrome, including higher fasting...

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications,

A synthetic analog of PAF C-16 with approximately 3-10 times increased potency.

A highly potent (IC50 = 12 nM) cPLA2α inhibitor; demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.

A certified reference material that is structurally similar to known phytocannabinoids; has been found as a byproduct in Cannabis processing; potential impurity or degradant in preparations of ?9-THC,,

A thiol-reactive probe that can be used to label proteins at cysteine residues.

A methylxanthine derivative; has anti-inflammatory activity, inhibiting LPS-induced TNF-α production in isolated peripheral blood mononuclear cells (IC₅₀ = 85 µM) and suppressing LPS-induced leukopenia in mice.

Triton X-100 (20% v/v) stock solution contains 20% Triton X-100. It is ready to use as supplied.

A selective allosteric modulator of M2 receptors that hinders the dissociation of the orthosteric antagonist N-methylscopolamine from the M2 receptor (EC₅₀ = 3 nM).

A naturally-occurring dimethyl ether analog of resveratrol; acts as a powerful antioxidant, suppresses the synthesis of PGE2 from LPS-stimulated human peripheral blood mononuclear cells (IC₅₀ = 1.0 μM), and inhibits cell proliferation (IC₅₀ = ~60 μM); evokes effects that...

A cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC₅₀ = 15 μM); inhibits clathrin-dependent vesicle formation and endocytosis; can also augment the release of neurotransmitters and secreted cytokines.

Antigen: human GPR12 amino acids 323-334 Host: rabbit Cross Reactivity: (+) human GPR12 receptor Application(s): FC and ICC

An orally bioavailable 8-hydroxyadenine analog that induces IFN production by binding to TLR7 on immune cells; induces IFNα in human peripheral blood mononuclear cells (EC₅₀ = 0.14 µM); reduces HCV in Huh7 cells that carry a HCV replicon.

A prodrug of sodium salicylate that can reduce blood glucose, triglyceride, free fatty acid and C-reactive protein concentrations; can improve glucose utilization; and can increase circulating insulin and adiponectin concentrations in obese adults at risk for the development of type 2 diabetes and...

An HDAC inhibitor (IC₅₀s = 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively); possesses six6-fold extended half-life for binding on HDAC2 compared to HDAC1 (381 min vs. 65 min); rescues the memory defects associated with p25 induced neurodegeneration in contextual fear...

Antigen: purified ovine COX-1 Host: rabbit Cross-Reactivity: reacts with both COX-1 and -2; affinity for COX-1>COX-2 Application(s): WB and IHC

PPARs are ligand-activated transcription factors belonging to the large superfamily of nuclear receptors. PPARα primarily activates genes encoding proteins involved in fatty acid oxidation, while PPARγ primarily activates genes directly involved in lipogenic pathway and insulin...

A cephalosporin antibiotic that is active against most Gram-positive cocci, including penicillinase-producing Staphylococci, and against Gram-negative bacteria such as N. gonorrhoeae, E. coli, K. pneumonia, Salmonellae, Shigella, and some strains of H. influenza; specifically inactivates PBP3, which...

A verapamil derivative that dose-dependently blocks calcium uptake via Na+/Ca2+ exchange in diverse types of cells (Ki = 28 µM); also prevents calcium release from mitochondria induced by Ruthenium Red but not by uncouplers, respiratory inhibitors, or a chelating agent.

Recombinant N-terminal GST-tagged protein expressed in E. coli MBD2 specifically binds to methylated promoters on CpG islands. MBD2 binding to 5mC facilitates the recruitment of chromatin remodeling and transcriptional repressor complexes, which results in a repressive chromatin state.

EPA is an ω-3 fatty acid abundantly available in marine organisms. (±)17(18)-DiHETE is one of the major metabolites produced when EPA is incubated with various rat tissue homogenates or cynomolgus monkey seminal vesicles. The route of production of (±)17(18)-DiHETE likely...

Differs from the major microcystin variant LR with the substitution of alanine in place of the arginine; inhibits both PP1C and PP2A with an IC50 value of 0.3 nM.