Cayman Chemical

A flavanone rutinoside found in citrus peels with antioxidant, anticancer, and estrogenic effects in in vitro and in vivo research models; increases the cytotoxicity of doxorubicin on MCF-7 and HeLa cancer cells; decreases serum and hepatic lipid concentrations and reduces osteoporosis in...

An endogenous biogenic amine commonly found in invertebrates; similar to norepinephrine in structure and action in invertebrates; considered a trace amine which may interfere with aminergic pathways in humans.

An analog of AEA that potentiates the activity of endogenous AEA by blocking its re-uptake into presynaptic neurons; selectively inhibits the carrier-mediated transport of AEA without affecting anandamide hydrolysis; inhibits the transport of AEA with an IC₅₀ value of 1 µM in rat...

Reversibly inhibits dihyroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines, preventing DNA synthesis of activated lymphocytes (IC₅₀s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively); also inhibits tyrosine kinases responsible for...

Molecular Formula: C₂₉H₂₂N₃O₁₄ • 5K

A synthetic retinoid that induces ceramide in tumor cell lines, leading to caspase-dependent apoptosis (IC₅₀ = 2.4 µM); promotes ROS generation, MCL-1 degradation, and PKCδ cleavage; selectively activates RARγ at 5-20 µM and inhibits the growth of cancer cells.

A derivative of glucose used to study carbohydrate metabolism, particularly in the identification, differentiation, and characterization of α-phosphoglucomutase, β-phosphoglucomutase, and α- and β-hexoglucomutases.

An orally active, selective inhibitor of p38α and p38β (IC₅₀s = 1 and 11 µM, respectively, in vitro); blocks the release of TNF-α and IL-1β from peripheral blood mononuclear cells stimulated with LPS (IC₅₀s = 3 and 11 nM, respectively) and inhibits...

An alkaloid originally found to have antimicrobial actions; both 5-LO and COX-2 (IC₅₀s = 600 and 64 nM, respectively); suppresses angiogenesis, blocking signaling through VEGFR2 at the level of ERK1/2 signaling; prevents ERK signaling through Nrf2, reducing oxidative stress-induced...

8(S)-HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. It acts to promote hatching of barnacle eggs at 10 nM, although it is not clearly identified as the natural egg hatching factor.

Ins(1,3,5)P3 is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by PLC-mediated hydrolysis of PtdIns-4,5-biphosphate. Binding of...

A cyclic hexadepsipeptide mycotoxin that has insecticidal and phytotoxic activity; induces apoptosis in human NSCLC cells.

A dual inhibitor of both PI3K and mTOR, completely blocking phosphorylation of substrates at 8-16 µM; induces cell death in GBM xenografts in vitro, with half maximal inhibition occurring at 3.7-7.7 µM; orally bioavailable, reducing the growth of intracranial GBM xenografts in mice.

Consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker, which are released upon hydrolysis of the prodrug linker in vivo; inhibits the growth of tumors in mice better than rapamycin alone.

A diacetylated derivative of spermine that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine; used as a biomarker for cancer detection.

A picolinic acid derivative first isolated from fungi of the genus Fusarium; transformed to an N-methylamide derivative by many plant species.

A metabolite of 8-iso PGF2α in rabbits, monkeys, and humans.

An indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes; acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.

13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. It inhibits the ADP-induced aggregation of human platelets with an ED₅₀ of about 40 nM in PRP and 77 nM in washed platelets, which is comparable to the potency of carbaprostacyclin.

A selective, brain-penetrable LRRK2 inhibitor (Ki = 0.7 nM); inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation (IC₅₀ = 3 nM in vivo).

A tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFR-β (IC₅₀ = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively); causes regression of fenestrated, VEGFR-rich capillaries in tumors and normal tissue of mice.

A Hsp90 inhibitor (IC50 = 21 nM in a FP binding assay) that prevents the proliferation of a range of human cancer cell lines in vitro (GI50s ~ 9nM); 50 mg/kg inhibits tumor growth in a human colon cancer xenograft model by ~50% compared to vehicle controls.

Antigen: human TLR9 amino acids 268-284  Host: mouse, clone 26C593.2 Cross Reactivity: (+) canine, equine, human, mouse, rat, and Rhesus monkey TLR9 Application(s): FC (intracellular and cell surface), ICC, IHC (frozen and paraffin), and WB Gene knockout experiments suggest that TLR9 acts as a...

The measurement of FFA can be useful in determining metabolic status. Cayman’s Free Fatty Acid (FFA) Assay can be used for measuring free fatty acids in plasma, serum, and urine. The FFA Assay utilizes a coupled enzymatic reaction that results in generation of the highly fluorescent product...