Cayman Chemical

A synthetic corticosteroid that is commonly delivered in injectable, topical, or nasal preparations; suppresses allergic, inflammatory, and immune responses.

A glucocorticoid.

9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol....

Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage...

15(R)-HEDE is isolated by the chromatographic resolution of (±)15-HEDE. There are no reports of biological activity associated with 15(R)-HEDE in the literature.

An acyl-CoA donor that can be metabolically transferred onto lysine residues of proteins by lysine acetyltransferases; an azide-alkyne bioconjugation reaction, known as click chemistry, can then be used to tag the acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.

A potent inhibitor of both human and mouse soluble epoxide hydrolase (IC50 = 3.7 and 2.8 nM, respectively); has superior pharmacokinetics compared to the 1-adamantylurea based inhibitors, like AUDA.

A metabolite of atrazine.

A cell-impermeable kinase inhibitor, first described as an inhibitor of PKC; used to inhibit extracellular kinases (ectokinases) of cells in culture; inhibits receptor-mediated degranulation from RBL-2H3 cells (IC50 = 0.5 μg/ml); also used in comparison studies with the cell-permeable inhibitor...

A potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM); produced in vivo via the metabolism of the prodrug acetorphan.

A selective RARβ and RARγ antagonist (Kds = 110, 306, and > 2,250 nM for RARγ, RARβ, and RARα, respectively, with no binding at RXRα).

An AGE, produced by the oxidative modification of glycated proteins during oxidative stress; increases with aging and during pathologies marked by oxidative stress; activates RAGE, triggering signaling through MAPKs and NF-κB.

An ω-7 monounsaturated fatty acid that is a common constituent of the triglycerides of human adipose tissue; raises LDL cholesterol and lowers HDL cholesterol much like that of a saturated fatty acid, even when dietary intake of cholesterol is maintained at a low level.

A selective inhibitor of the reverse mode of NCX1 (IC₅₀ = 1.2-2.4 µM) that prevents intracellular sodium-dependent calcium uptake in whole cells; exhibits neuroprotection from glutamate-induced excitotoxicity; inhibits TRPC channels involved in calcium-dependent signal transduction.

An antagonist of the transcription factor Gli, inhibiting Gli1 activation of gene expression with an IC₅₀ value of 5 μM; does not affect signaling through several other pathways, supporting specificity for the Hedgehog pathway; has been shown to inhibit the proliferation of cancer...

An isomer of Vitamin E that has less potent antioxidant properties than α-tocotrienol.

FFAR4/GPR120 is a G protein-coupled receptor for long chain fatty acids such as DHA and EPA ω-3 fatty acids. It is involved in the regulation of glucose uptake in adipocytes and mediates anti-inflammatory activity in macrophages. Cayman’s FFAR4 (GPR120) Reporter Assay Kit consists of a...

Racemic version of a product of epoxide hydrolase metabolism of leukotoxin, the 9(10) epoxide of linoleic acid generated by neutrophils during the oxidative burst.

Antigen: recombinant human FTO Host: mouse, clone FT 62-6 Cross Reactivity: (+) mouse FTO, (−) rat FTO Application(s): ELISA, IHC, IP, and WB FTO is associated with type 2 diabetes and positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin,...

A mixture of compounds that can be isolated from plants in the genus Cannabis; designed for use as a reference standard for these major controlled substances during routine analytical checks using HPLC-UV or LC- or GC-MS instrumentation; provided as a

AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2’-epimerase (DprE1) with an IC₅₀ value of 10 nM. It also inhibits PDE6 with an IC₅₀ value of 4 µM. AZ 7371 has been shown to be active against M. tuberculosis with an MIC range of 0.78-3.12...

An aporphine alkaloid that possesses antioxidant and free-radical scavenging ability and has been linked to anti-inflammatory, anti-pyretic, anti-diabetic, anti-atherogenic, anti-platelet, anti-tumor, UV-protective, and hepatoprotective effects.

(±)7-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also produces 7-HDHA. However, the enzymatic product is most likely the S-isomer. (±)7-HDHA...

A racemic mixture of natural polyphenols that inhibits spermatogenesis; has antimalarial properties, preventing the growth of P. falciparum; inhibits aldose reductase (Ki = 0.5 µM); inhibits growth in various cancer cell lines at low micromolar concentrations.