Cayman Chemical

A 5-series LO derived from EPA; contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4, yet does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA4 and LXB4.

An inhibitor of ULK1 (IC₅₀ = 108 nM) that is less effective against ULK2 (IC₅₀ = 711 nM); suppresses autophagy induced by mTOR inhibition and blocks ULK1-dependent cell survival following nutrient deprivation.

Immunogen: human fibrinogen (α chain) Host: mouse Species Reactivity: (+) human Application(s): WB

A synthetic corticosteroid that is commonly delivered in injectable, topical, or nasal preparations; suppresses allergic, inflammatory, and immune responses.

A glucocorticoid.

9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol....

Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage...

15(R)-HEDE is isolated by the chromatographic resolution of (±)15-HEDE. There are no reports of biological activity associated with 15(R)-HEDE in the literature.

An acyl-CoA donor that can be metabolically transferred onto lysine residues of proteins by lysine acetyltransferases; an azide-alkyne bioconjugation reaction, known as click chemistry, can then be used to tag the acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.

A potent inhibitor of both human and mouse soluble epoxide hydrolase (IC50 = 3.7 and 2.8 nM, respectively); has superior pharmacokinetics compared to the 1-adamantylurea based inhibitors, like AUDA.

A metabolite of atrazine.

A cell-impermeable kinase inhibitor, first described as an inhibitor of PKC; used to inhibit extracellular kinases (ectokinases) of cells in culture; inhibits receptor-mediated degranulation from RBL-2H3 cells (IC50 = 0.5 μg/ml); also used in comparison studies with the cell-permeable inhibitor...

A potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM); produced in vivo via the metabolism of the prodrug acetorphan.

A selective RARβ and RARγ antagonist (Kds = 110, 306, and > 2,250 nM for RARγ, RARβ, and RARα, respectively, with no binding at RXRα).

An AGE, produced by the oxidative modification of glycated proteins during oxidative stress; increases with aging and during pathologies marked by oxidative stress; activates RAGE, triggering signaling through MAPKs and NF-κB.

An ω-7 monounsaturated fatty acid that is a common constituent of the triglycerides of human adipose tissue; raises LDL cholesterol and lowers HDL cholesterol much like that of a saturated fatty acid, even when dietary intake of cholesterol is maintained at a low level.

A selective inhibitor of the reverse mode of NCX1 (IC₅₀ = 1.2-2.4 µM) that prevents intracellular sodium-dependent calcium uptake in whole cells; exhibits neuroprotection from glutamate-induced excitotoxicity; inhibits TRPC channels involved in calcium-dependent signal transduction.

An antagonist of the transcription factor Gli, inhibiting Gli1 activation of gene expression with an IC₅₀ value of 5 μM; does not affect signaling through several other pathways, supporting specificity for the Hedgehog pathway; has been shown to inhibit the proliferation of cancer...

An isomer of Vitamin E that has less potent antioxidant properties than α-tocotrienol.

FFAR4/GPR120 is a G protein-coupled receptor for long chain fatty acids such as DHA and EPA ω-3 fatty acids. It is involved in the regulation of glucose uptake in adipocytes and mediates anti-inflammatory activity in macrophages. Cayman’s FFAR4 (GPR120) Reporter Assay Kit consists of a...

Racemic version of a product of epoxide hydrolase metabolism of leukotoxin, the 9(10) epoxide of linoleic acid generated by neutrophils during the oxidative burst.

Antigen: recombinant human FTO Host: mouse, clone FT 62-6 Cross Reactivity: (+) mouse FTO, (−) rat FTO Application(s): ELISA, IHC, IP, and WB FTO is associated with type 2 diabetes and positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin,...

A mixture of compounds that can be isolated from plants in the genus Cannabis; designed for use as a reference standard for these major controlled substances during routine analytical checks using HPLC-UV or LC- or GC-MS instrumentation; provided as a

AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2’-epimerase (DprE1) with an IC₅₀ value of 10 nM. It also inhibits PDE6 with an IC₅₀ value of 4 µM. AZ 7371 has been shown to be active against M. tuberculosis with an MIC range of 0.78-3.12...