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An aporphine alkaloid that possesses antioxidant and free-radical scavenging ability and has been linked to anti-inflammatory, anti-pyretic, anti-diabetic, anti-atherogenic, anti-platelet, anti-tumor, UV-protective, and hepatoprotective effects.
(±)7-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also produces 7-HDHA. However, the enzymatic product is most likely the S-isomer. (±)7-HDHA...
A racemic mixture of natural polyphenols that inhibits spermatogenesis; has antimalarial properties, preventing the growth of P. falciparum; inhibits aldose reductase (Ki = 0.5 µM); inhibits growth in various cancer cell lines at low micromolar concentrations.
An alkaloid metabolite of nicotine as well as a major product of its pyrolysis; binds comparably to CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM, respectively), but appears to more effectively inactivate CYP2A6.
One of the phenolic antioxidants present in extracts of rosemary; inhibits the formation of tumors derived using irritants such as TPA and DMBA.
An enhancer of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington’s, Parkinson’s, and Alzheimer’s diseases.
An agonist of α2 adrenergic receptors (Ki = 194 nM); used for sedation, anesthesia, and analgesia in non-human mammals.
A natural bacterial product used, in certain formulations, as an oral antibiotic for fungal infections of the skin; alters microtubule dynamics, resulting in metaphase arrest.
A selective inhibitor of the TGF-β type1 receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively); used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via...
An aldose reductase inhibitor that blocks the conversion of glucose to sorbitol (Kis = 7.7 nM and 60 µM, for aldose reductase 2 and 1, respectively); prevents diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats; impairs the synthesis of PGF2α...
A potent and selective AhR antagonist (Ki = 1.2 nM).
A chromogenic substrate for endoglucanases and cellobiohydrolases.
CAS Number: 1094873-14-9 Molecular Formula: C34H36FN5O2 Formula Weight: 565.7
An internal standard for the quantification of latanoprost (free acid) by GC- or LC-MS.
An analog of SB203580, the highly specific pyridinylimidazole inhibitor of p38 MAPK; inhibits IL-1 production in the human monocytic cell line THP (IC50 = 0.20 µM) and binds CSAID binding protein, a serine/threonine kinase homologous to p38, inhibiting its kinase activity (IC50 = 0.03...
A centrally acting antihypertensive agonist that targets I1 imidazoline receptors with a Ki value of 7.1 nM and demonstrates weaker affinity for I2 (Ki = 5.2 µM) and α2-adrenergic receptors; induces autophagy as evidenced by a dose-dependent increase of LC3-II levels in PC12 cells.
An inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells; blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells.
An analog of thalidomide that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines; induces proliferation and enhances the functional capacity of T-lymphocytes, amplifying co-stimulatory signaling pathways.
A cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM); reversibly impairs endosomal trafficking in NIH3T3 cells and blocks retroviral exit by budding from cells; inhibits basal and insulin-activated 2-deoxyglucose uptake (IC50 = 54 nM) in adipocytes.
An inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 (Kis = 0.10 and 1.60 μM, respectively); approved for use in reducing cortisol, aldosterone, and corticosterone levels in dogs diagnosed with Cushing’s syndrome; may potentially benefit the treatment of breast cancer in...
A cell-permeant precursor of the fluorescent calcium indicator rhod-FF, a fluorescent calcium indicator that displays a very low affinity for calcium (Kd = 320 µM).
13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 13(R)-HODE cholesteryl ester can be used as a standard for...
A selective ligand for the lipid-binding protein NUCB1, blocking binding of the probe arachidonoyl ethanolamide-diazirine with an IC50 value of 3.3 µM.
An antibiotic produced by some isolates of P. fluorescens that is active against numerous plant pathogenic fungi, viruses, bacteria, and nematodes; used to increase crop yield by controlling plant root diseases.