Cayman Chemical

Glutathione (GSH) is involved in maintenance of protein sulfhydryl reduction status. PSSG may modify the activity of a large number of cell proteins, including metabolic, structural, cytoskeletal, and signaling proteins. Cayman’s PSSG provides a convenient method for the direct visualization...

11-dehydro-2,3-dinor TXB2 has been identified as a TXB2 metabolite in human urine by GC/MS. The relative abundance is only about one-tenth that of 11-dehydro TXB2, making it unlikely that 11-dehydro-2,3-dinor TXB2 will be used widely as an index of thromboxane synthesis.

A corticosteroid prodrug that is converted to its active form, des-CIC, a glucocorticoid receptor agonist (Ki = 0.31 nM); used to ameliorate symptoms of airway inflammatory diseases.

An oxidized metabolite of sulindac that is produced in many mammals but minimally in mice and rats; generally considered to be inactive against COX enzymes, although it can reduce azoxymethane-induced colon cancer in rats; inhibits aldose reductase (IC₅₀ = 367 nM) in vitro.

A major Alternaria mycotoxins commonly found as a food contaminant (LD50 = 548 μg/egg in the chicken embryo toxicity assay) and linked to esophageal cancer in human populations at risk of high exposure; Mice fed 100 mg/kg/day orally for 10 months developed precancerous lesions on the esophageal...

A sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, blocking the activation of calmodulin-dependent phosphodiesterase with an IC₅₀ value of 9 μM.

Sphingomyelin is an important lipid component of cell membranes and lipoproteins. Cayman’s SM Assay provides a specific, sensitive, and convenient method for quantifying SM in plasma or serum in a 96-well format with a colorimetric readout at 595 nm.

A non-selective COX inhibitor with IC₅₀ values for ovine COX-1 and -2 of 0.1 and 6 µM, respectively; IC₅₀ values for human recombinant COX-1 and -2 are 1.67 and 24.6 µM, respectively.

A potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC₅₀ = 14.36 nM); blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression; effective in vivo, preventing the development of fibrosis in...

A selective cell-permeable inhibitor of non-muscle myosin II ATPases, inhibiting Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC₅₀ = 80 μM).

A selective PI3K inhibitor that targets the β isoform more potently than PI3Kδ, PI3Kγ, or PI3Kα (IC₅₀s = 0.69, 13.6, 47.8, and 136 nM, respectively); blocks Akt signaling and tumor growth in a large number of cancer cell lines and suppresses the growth of...

A selective inhibitor of human CYP1A2 (IC₅₀ = 0.07 µM), demonstrating little effect on other CYP isoforms including 2D1, 2C, 3A, or 1A1.

A selective inhibitor of MCT1 (Ki = 1.6 nM), killing tumor cells that are reliant on glycolysis by blocking lactate transport; increases intratumor lactate levels and decreases tumor growth in mice bearing SCLC xenografts.

An inhibitor of the DUBs USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 (EC₅₀s = 45, 37, and 9.8 µM, respectively); inhibits apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation.

A potent, highly selective, and centrally active antagonist at the mGlu5a receptor subtype (IC₅₀ = 36 nM); also has been reported as a positive allosteric modulator of mGluR4 at higher concentrations.

An intracellular iron chelator and an inhibitor of topoisomerase IIα that is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury; scavenges hydroxyl (IC₅₀ = 2.1 mM), superoxide (IC₅₀ = 0.4 mM), lipid (IC₅₀ = 4.4 mM), DPPH...

Ins(1,4,5,6)-P4 is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella....

A selective inhibitor of 12-LO (IC₅₀ = 0.34 µM) with greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC₅₀s = 9.7, >100, and >100 µM) and no inhibition of COX1/2; decreases platelet aggregation in patient-derived human platelets and inhibits arachidonic...

A mixture of the natural macrocyclic lactones avermectin B1a and avermectin B1b that has both insecticidal and anthelmintic actions.

A loop diuretic with good absorption and pharmacodynamic properties; acts as an inhibitor of NKCC1 and the kidney-specific NKCC2 (Ki = 0.5 and 59 μM for human and rabbit NKCC1, respectively).

Antigen: hamster iPLA2 amino acids 557-576 (PRFNQNINLKPPTQPADQLV) Host: rabbit Cross Reactivity: (+) human, mouse, bovine, hamster, and rat iPLA2; (−) cPLA2 and sPLA2 Application: WB

A potent peptide agonist of the GLP-1 receptor (Ki = 136 pM); stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes; protects hippocampal neurons against glutamate-induced apoptosis.

C-12 NBD ceramide is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity. It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral...