A selective inhibitor of 12-LO (IC50 = 0.34 µM) with greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM) and no inhibition of COX1/2; decreases platelet aggregation in patient-derived human platelets and inhibits arachidonic acid and calcium ionophore-induced 12-HpETE in mouse BTC3 cells and human islets.