An HDAC inhibitor (IC50s = 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively); possesses six6-fold extended half-life for binding on HDAC2 compared to HDAC1 (381 min vs. 65 min); rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration.