A hybrid molecule patterned after N-arachidonoyl serotonin; while saturated 11- or 12-carbon fatty acids linked to serotonin potently inhibit capsaicin-induced TRPV1 channel activation (IC50 = 0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM), the effects of palmitoyl serotonin are unknown.