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Antigen: recombinant human H-PGD synthase Host: rabbit Cross-reactivity: (+) human and mouse H-PGD synthase Applications: WB and IHC
An endogenous agonist for LXRα (EC50 = 325 nM) that can induce the expression of the ABCA1 reverse cholesterol transporter to inhibit the overall absorption of cholesterol; used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR...
5,6,7,8-tetrahydro-2(1H)-Quinolinone is a synthetic intermediate useful for pharmaceutical synthesis.
BW A868C is a hydantoin compound that is structurally related to the DP receptor agonist BW 245C. BW A868C antagonizes the PGD2 and BW 245C-induced activation of human platelet adenylate cyclase. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise,...
A small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM; 15 mg/kg/day administered to diabetic db/db mice improved glucose tolerance, pyruvate tolerance, and...
A non-enzymatic hydrolysis product of LTA4 with reduced activity compared to LTB4; also produced by oxidative decomposition of CysLTs such as LTC4 in the presence of myeloperoxidase and hypochlorous acid.
Consists of stearidonic acid, an ω-3 PUFA, with glycine attached at its carboxy terminus.
A selective CB1 receptor inverse agonist (Ki = 1.8 nM).
A precursor of sialic acid that increases sialylation in kidney, liver, blood cells, brain, spinal cord, muscle, heart, lung, and spleen.
Tris-HCl Stock Solution (1 M, pH 7.5) contains filtered Tris-HCl (1 M, pH 7.5). It is ready to use as supplied.
A dual inhibitor of IGF-1R and InsR kinases (IC50s = 35 and 75 nM, respectively); inhibits proliferation of tumor cell lines in vitro and has antitumor efficacy in an IGF-1R-driven xenograft mouse model when administered orally.
An internal standard for the quantification of 17-phenyl trinor PGF2α ethyl amide by GC- or LC-MS.
A small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism.
L-NNA is an inhibitor of NOS with some selectivity for the neuronal and endothelial isoforms. It exhibits Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively.
An inactive neurotoxin used as a vaccine to produce immunity to tetanus; functions as a carrier of conjugated polysaccharides in the development of vaccines against encapsulated bacterial pathogens.
A lipophilic analog of PGA2 which may be more suitable for certain formulations or applications.
Immunogen: Synthetic peptide from the N-terminal region of mouse protein MC4R Host: Rabbit Species Reactivity: (+) Human, mouse, and rat MC4R Applications: IHC (formalin-fixed paraffin-embedded sections) and WB MC4R receptor plays a critical role in appetite regulation and is a prime target for...
Butaprost, a structural analog of PGE2, is a selective agonist for the EP2 receptor subtype. EP2 receptors are expressed on human neutrophils and on respiratory, vascular, and uterine smooth muscle. Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does...
Antigen: recombinant adenovirus expressing full-length mouse CD36 Host: CD36 null mouse, clone JC63.1 Cross Reactivity: (+) human, mouse, and rat CD36 Application(s): FC, functional blocking, and ICC Functioning as a receptor for oxidized LDL, CD36 is a type-B scavenger receptor that is necessary...
Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivo TXA2 synthesis. The mean plasma level...
Antigen: human COX-2 amino acids 580-599 Host: mouse, clone CX229 Cross-Reactivity: (+) human and ovine COX-2; (−) mouse, rat, and rabbit COX-2 and COX-1 (all species) Application(s): (+) FC and ICC; (−) IHC and WB Isotype: IgG1 This product is derived by labeling the COX-2 monoclonal...
A member of the rifamycin class of antibiotics, inhibiting bacterial DNA-dependent RNA synthesis (Ki = ~ 1 nM); activates PXR (EC50 = ~2 µM), up-regulating enzymes that alter drug metabolism; inhibits OATPs with Ki/IC50 values ranging from 0.58-18 µM.
A well-characterized natural advanced glycation end (AGE) that is often used as a biomarker for the production of all AGEs.
A stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases; used in experiments to increase levels of cytoplasmic D-glutamate, or in studies examining the cellular effects of 5-octyl D-glutamate or 5-octyl α-ketoglutarate.