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Propofol ß-D-glucuronide is a metabolite of the anesthetic and sedative propofol.{66360} It is formed from propofol from the UDP-glucuronosyltransferase (UGT) isoform UGT1A9.
Lyso-PAF C-16 can be formed by either the action of PAF-AH on PAF C-16, or by the action of a CoA-independent transacylase on 1-O-hexadecyl-2-acyl-glycerophosphocholine. Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid...
A derivative of the amide of ricinoleic acid that shows potent antiproliferative activity against an array of cancer cell lines.
Molecular Formula: C13H11F3O4
A selective, irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 72 nM) that is activated more rapidly and over a greater pH range than many other proton pump inhibitors, including omeprazole, lansoprazole, and pantoprazole.
PGD1 is the theoretical D-series metabolite of DGLA, but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2.
8-Isoquinoline methanamine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
A selective inhibitor of EZH2 that prevents the methyltransferase activity of wild-type and mutant EZH2 with similar potency (Kiapp = 3-27 nM); effective in vivo in mouse models of cancer.
An intermediate in the synthesis of ipratropium.
Formal Name (2E,4E)-N-(2-methylpropyl)-2,4-decadienamide CAS Number 18836-52-7 Synonyms BRN 1725967 Molecular Formula C14H25NO Formula Weight 223.4
A selective inhibitor of HDAC3 (IC50 = 289 nM) that alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.
A constituent of human and rat brain in which the ethanolamine moiety is attached “backwards”, as an ester rather than as an amide as in AEA; has mixed agonist/antagonist activity at the CB1 receptor.
A β1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity; often used to examine the activity of the drug-transporting MDR1 gene product P-glycoprotein.
A TNKS2 inhibitor.
A synthetic intermediate useful for pharmaceutical synthesis.
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase. PGD2...
INDIGO's Aryl Hydrocarbon Receptor (AhR) Reporter Cells include the luciferase reporter gene functionally linked to an AhR-responsive promoter. Thus, quantifying changes in luciferase expression in the treated reporter cells provides a sensitive surrogate measure of the changes in AhR activity....
An internal standard for the quantification of 5-oxoETE by GC- or LC-MS.
7-chlorothieno[2,3-c]Pyridine is a synthetic intermediate useful for pharmaceutical synthesis.
Inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively); possesses antiangiogenic and antitumor properties.
An internal standard for the quantification of (±)8,9-DiHET (Item No. 51351) by GC- or LC-MS.
A cell-permeant acetoxymethyl ester of the calcium chelator EGTA.
Member of a complex family of macrocyclic lactones produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus; nematocide and insecticide activity via the potentiation of glutamate and GABA-gated chloride-channel opening; IC50s = 5.3, 41.1, and 9.5...
Antigen: E. coli Trx1 Host: sheep