Cayman Chemical

A stable, cell-permeable tryptophan derivative with an octyl ester protected COOH group.

An internal standard for the quantification of (±)-β-hydroxybutyrate (sodium salt) by GC- or LC-MS.

UNBS5162 is a naphthalimide that antagonizes the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days was shown to decrease the expression of proangiogenic CXCL chemokines. UNBS5162 also demonstrates antiangiogenic properties...

A highly potent, reversible inhibitor of the EGFR (Ki = 5.2 pM; IC₅₀ = 29 pM); rapidly suppresses autophosphorylation of EGFR in ?broblasts and human epidermoid carcinoma cells.

A small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172.

PGF1α-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry.

A natural flavonoid that has potent antioxidant and anti-inflammatory properties; acts as an antagonist of AhR, inducing apoptosis in cancer cells; also inhibits CYP1A1 with an IC₅₀ value of less than 1 µM.

An EphB3 kinase inhibitor.

GSTs are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. The enzymes protect cells against toxicants by conjugating them to glutathione thereby neutralizing their electrophilic sites and rendering the products more water-soluble. Cayman’s GST Assay...

A double prodrug that undergoes in vivo hydrolytic cleavage to produce dabigatran, a potent thrombin inhibitor (Ki = 4.5 nM); shows antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action.

Source: recombinant protein N-terminal His-tag expressed in E. coli Mr: 19 kDa Protein concentration: 0.5 mg/ml

A mycotoxin that specifically and reversibly inhibits sarco-endoplasmic reticulum Ca2+-ATPases (SERCA; IC50 = 0.6 μM); effectively inhibits SERCA in intact tissue, in smooth muscle and endothelium, as well as in isolated cells.

A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC₅₀s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.

A major metabolite of sulforaphane that has been shown induce ARE-driven gene expression with roughly 8-fold less potency than sulforaphane.

A phenothiazine classified as an antipsychotic compound; antagonizes dopamine and serotonin receptors (Kis = 0.66, 0.84, 1.2, and 1.8 nM for D2, D3, D4, and 5-HT2A, respectively); also antagonizes histamine, α1- and α2-adrenergic, and muscarinic acetylcholine receptors.

Mono-unsaturated fatty acids are components of the cellular membranes of autotrophic bacteria. The specific composition and abundance of membrane fatty acids can be used to identify specific genera of bacterial populations in natural environments (e.g., mining lakes, etc.). cis-7-Hexadecenoic acid...

CAS Number: 2719-05-3 Synonyms: FH1; Methylenebis-4,4'-acetanilide; NSC 12407 Molecular Formula: C₁₇H₁₈N₂O₂ Formula Weight: 282.3

Cayman’s MT Fluorometric Assay is a continuous enzyme-coupled assay that can continuously monitor SAM-dependent MTs. The removal of the methyl group from SAM generates AdoHcy, which is rapidly converted to urate and H2O2 by an enzyme mixture provided in the kit. The reaction between H2O2 and...

An inhibitor of EGF receptor kinase with an IC50 value of 3 µM in the human epidermoid carcinoma cell line A431.

A certified reference material categorized as a phytocannabinoid; has been found in Cannabis samples seized by law enforcement; intended for research and forensic applications

AD140 is an orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM) that binds to the androgen receptor with a Ki value of 7 nM. At 0.03-0.3 mg/kg, it has been shown to stimulate muscle weight increase without affecting prostate or seminal vesicle in castrated male rats. At...

A stabilized ethyl ester form of this ω-3 C20:5 PUFA; dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels, down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels; blocks induced insulin resistance and corrects changes in...

An inhibitor of EGFR and VEGFR tyrosine kinases (IC₅₀s = 2, 6, 77, and 59 nM for EGFR, ErbB2, KDR, and FLT1, respectively); demonstrates antitumor activity and anti-angiogenic activity in numerous in vitro and in vivo models.

(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid peroxidation...