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A lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α.
An internal standard for the quantification of tetranor-PGDM by GC- or LC-MS.
The major metabolite of α-phenyl-α-(2-pyridyl)thioacetamide produced by the supernatant fraction of rat liver homogenate.
A selective CaMKII inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.
A GABAA receptor agonist (IC50 = 19 nM) that has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex.
The defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission; contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer.
The prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of Ca2+ (IC50 = 0.38 μM in guinea pig aortic strip).
PGD2 dopamine is a conjugate of the neurotransmitter dopamine and PGD2. It can be used to study the biological function of PGD2 in the brain and periphery.
A tyrosine kinase inhibitor that potently inhibits Bcr/Abl tyrosine kinase and is effective in the treatment of certain leukemias; ~20-fold more potent than imatinib in inhibiting Bcr/Abl (e.g., IC50 = 15 versus 280 nM, respectively).
A fluorescent probe for monitoring intracellular pH by flow cytometry in living cells.
A potent BRD9 bromodomain inhibitor.
A Cdc25 phosphatase inhibitor (IC50 = 0.82 µM for human recombinant Cdc25B); arrests asynchronous PC-3 prostate cancer cells in G2/M phase at 20 µM.
A fluorogenic substrate that can be cleaved specifically by caspase-8, caspase-3 processing enzyme, caspase-10, and granzyme B.
The hydrochloride of leelamine, an inhibitor of pyruvate dehydrogenase kinase.
An NSAID that non-selectively and reversibly inhibits both COX isoforms (IC50 = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).
A product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine; as a biomarker of nicotine metabolism.
Antigen: oligomeric form of Aβ42 Host: mouse Isotype: IgG2b Cross Reactivity: (+) human Aβ; unaggregated, oligomeric and fibrillar forms of synthetic Aβ42, and unaggregated Aβ40; (−) human APP Application(s): WB, ELISA, ICC, and IP
An inhibitor of p300 histone acetyltransferase (KAT3B; IC50 = 1.98 µM in vitro); blocks acetylation of histones and p53 in cells treated with trichostatin A or etoposide, respectively, and reduces STAT3 phosphorylation.
A natural coumestan that inhibits NF-κB signaling at the level of IKK action, resulting in suppression of NF-κB-mediated gene expression at concentrations of 1-100 µM; also inhibits hepatitis C virus NS5B polymerase in vitro (IC50 = 36 µM), STAT1 dephosphorylation (50...
17-phenyl trinor-13,14-dihydro PGA2 is a synthetic PG analog whose biological activity has not been widely reported. The PGF2α analog latanoprost, which bears the same lower side chain features, has been approved as a pharmaceutical for the treatment of glaucoma.
A selective inhibitor of CaMKII, competitively blocking CaM binding to the kinase (Ki = 370 nM); inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM).
A reversible inhibitor of HPPD, an enzyme involved in the catabolism of tyrosine in mammals and the biosynthesis of plastoquinone in plants; used as a herbicide and also in the treatment of hereditary tyrosinemia type 1, alkaptonuria, and oculocutaneous albinism, all of which involve a disorder in...
An autoxidation product of DHA in vitro that can also be produced from incubation of DHA with rat liver, brain, and intestinal microsomes and enzymatic transformation of DHA by RBL-1 cells; is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.
A synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor; inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 µM respectively; has...