Cayman Chemical

A halogenated derivative of febrifugine that down-regulates Smad3, blocking TGF-β signaling relevant to fibrosis and tumor progression in a variety of different models; competitively inhibits prolyl-tRNA synthetase (Ki = 18.3 nM), preventing the differentiation of TH17 cells and blunting an...

Features Each vial contains a mixture of standards packaged in amber ampules purged with argon >1 ml provided at the concentration specified in the insert Designed for direct snap and inject use in mass spectrometry applications Ideally suited for method development and as a system suitability...

A small molecule antagonist of HNF4α that at 20 μM reduces endogenous insulin gene expression by as much as 50-fold in T6PNE cells; induces hepatic steatosis in vivo and is cyctotoxic to human hepatocellular carcinoma cell lines.

The methyl ester version of an unusual PUFA generated during the synthesis of docosahexaenoic acid-d5.

A potent in vitro inhibitor of sn-1 DAGLα (IC₅₀ = 18 nM); blocks the hydrolysis of sn-1-oleoyl-2-AG, the natural substrate of DAGLα, with a Ki value of 0.7 µM; inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6 in membrane preparations (Ki = 0.8...

Best known as a potent dual inhibitor of c-Src and Abl (IC50 = 1.2 and 1.0 nM, respectively); can be effective in regulating tumor growth and differentiation; also inhibits other members of the Src and TEC families and certain other kinases at nanomolar concentrations.

A fluorescently-tagged cholesterol with the hydrophilic NBD fluorophore attached to the hydrophilic end of cholesterol, separated by a 12-carbon spacer; allows the cholesterol to properly orient in membrane bilayers while the fluorescent tag is presented outside of the bilayer.

A selective IGF-1R kinase inhibitor (IC50 = 0.086 µM); prevents IGF-I-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 µM, respectively); dose-dependently inhibits tumor growth in a mouse NWT-21 fibrosarcoma tumor model.

A potent, dual PI3Kα/mTOR inhibitor (IC₅₀s = 0.9 and 0.6 nM, respectively); inhibits MDA361 (breast) and PC3 (prostate) tumor cell growth (IC₅₀s = in vivo.

A potent and specific antagonist of AhR that blocks activation by TCDD (IC₅₀ = 0.03 µM); prevents the induction of CYP1A1 by TCDD in HepG2 cells and in livers of mice; suppresses Th17 cell differentiation both in vitro and in vivo.

A bioactive compound that inhibits the growth of bacteria and mycobacteria (minimal inhibitory concentration = 0.05 μg/ml); suppresses TNF-α-stimulated IL-8 production in HUVECs (IC₅₀ = 0.01 μg/ml).

A natural inhibitor of exportin 1, preventing the export of proteins from the nucleus; reduces several intracellular signaling pathways, including NF-κB, impacting inflammation, cancer, viral replication, and other processes.

Tris-acetate EDTA stock solution (50X, pH 8.0) contains a concentrated solution of filtered Tris-acetate EDTA (TAE) buffer.

A potent inhibitor of 15-PGDH (Ki = ~0.1 nM) that has activity in vivo; rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection.

A stable, potent analog of erbstatin; inhibits EGFR tyrosine kinase in vitro with an IC50 of 0.14 µg/ml; inhibits EGF-stimulated growth in NIH3T3 cells with an IC50 value of 0.5 µg/ml; delays onset of EGF-induced DNA synthesis.

A broad-spectrum β-lactam antibiotic used for parenteral administration.

Epitope: Binds to N-terminal amino acids 16-25 of wild-type and mutant p53 Host: Mouse, clone BP53-12 Isotype: IgG2a Species Reactivity: (+) Human p53 Application(s): FC, ICC, IHC (paraffin-embedded sections), and WB Cellular p53, often called the 'guardian of the genome,' is a transcription...

Active metabolite of lactacystin, a widely used selective inhibitor of the 20S proteasome, with at least 10 times better activity; irreversibly alkylates subunit X of the 20S proteasome.

A long-chain ethanolamine that occurs at relatively high levels in rat CSF and presumably acts as an endocannabinoid.

A saturated triacylglycerol with heptadecanoate (17:0) side-chains attached at the C-1, C-2, and C-3 positions.

A reagent for blocking thiol (-SH) groups on proteins and peptides, as a first step of the thiosulfonate switch technique.

PTK is an analog of palmitic acid in which the COOH group is replaced by trifluoromethyl ketone. In P388D1 cells, PTK inhibits iPLA2 activity with an IC₅₀ value of 3.8 µM. A related compound, ATK is a less potent inhibitor of iPLA2 with an IC₅₀ value of 15 µM. PTK...

A cell-permeable, selective, and reversible inhibitor of Syk (IC₅₀ = 41 nM); prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC₅₀ = 460 nM) and inhibits passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).

A non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC₅₀ = 53 nM); reduces proliferation and increases differentiation of a ReNCell VM cell line derived from human ventral midbrain.