Cayman Chemical

An orally bioavailable, selective inhibitor of PDGFRα, PDGFRβ, and FLT3 (IC₅₀s = 11, 3.2, and 4 nM, respectively); also inhibits mutant forms of these kinases, including the D842V-containing form of PDGFR and D835Y and internal tandem duplication mutations of FLT3, at nanomolar...

A naturally-occurring but rare form of sphingosine.

A blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC₅₀ = 0.75 and 0.71 µM, respectively) as well as KCNQ2+3 heteromultimers (IC₅₀ = 0.6 µM); shows good in vivo potency and duration of action.

A synthetic heptapeptide that acts as a specific substrate for PKA.

A synthetic intermediate useful for pharmaceutical synthesis.

An enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 µM), P. aeruginosa, and K. pneumoniae; prevents the osmotic stress-induced increase in arginine decarboxylase activity and putrescine synthesis in oat leaf cells at 0.01 mM.

An inhibitor of 15-LO with an IC₅₀ value of 18 µM.

Valeroyl salicylate is a selective, irreversible inhibitor of COX-1. The IC₅₀ values for ovine COX-1 and -2 are 0.8 mM and 15 mM, respectively. The half-lives for inactivation of human recombinant and ovine COX-1 in the presence of 500 µM valeroyl salicylate are 12 and 45 minutes,...

Antigen: human MBOAT2, C-terminal region Host: rabbit Cross Reactivity: (+) human Application: FC and IF

A potent, cell-permeable inhibitor of all JAK isoforms (IC50 = 6.1, 12, and 8.0 nM for JAK1, JAK2, and JAK3, respectively); useful in ameliorating inflammatory or autoimmune components of a host of diseases.

A selective β1-adrenergic receptor antagonist (log KDs = -8.21, -7.38, and -5.97 for β1, β2, and β3, respectively) used to reduce intraocular pressure in research models of ocular hypertension and glaucoma.

(±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.

A water soluble, fluorescent near-infrared dye that can be conjugated to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via a sulfonyl substituent.

An orally active inhibitor of sPLA2-IIA; protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally; attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats.

A lysyl amide prodrug of the benzothiazole 5-fluoro 203, a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1, which leads to the formation of DNA adducts and cell cycle arrest.

A form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry; has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.

Collagen-induced arthritis (CIA) is an experimental autoimmune disease that is widely used as a model of human rheumatoid arthritis (RA) in the study of the pathogenic mechanisms of this disease and for testing potential therapeutics. Circulating levels of anti-type II collagen antibody are strongly...

A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases: p56lck (IC₅₀ = 4 nM), p59fynT (IC₅₀ = 5 nM), Hck (IC₅₀ = 5 nM).

A selective, reversible inhibitor of autotaxin, completely blocking the hydrolysis of the substrate bis-pNPP with an IC50 value of 28 nM; rapidly decreases plasma lysophosphatidic acid levels in mice when given intravenously (1 nM/g).

An analog of FTY720 that is a competitive antagonist of S1P1; has a Ki value of 0.69 µM when assessed by SEW2871-induced activation of S1P1.

A potent inhibitor of certain serine/threonine protein phosphatases, targeting the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM); a very weak inhibitor of PP2B (IC50 > 2 μM); does not inhibit PP2C or other phosphatases.

A COX metabolite of arachidonic acid and precursor for all 2-series ,PGs and TXs; acts as a TP receptor agonist and suicide substrate for TX synthase (Ki = 18 µM).

An aldotetrose carbohydrate that has been used in glycation studies and to characterize erythrose reductase activity.

A potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes); less effectively inhibits dopamine reuptake (Ki = 369 nM); effective in cells, tissues, and in vivo.