Cayman Chemical

A colorimetric peroxidase substrate that has been used as a substrate to semi-quantitatively measure lactate, uric acid, and glucose; spectrophotometrically measured at a wavelength of 405 nm.

Cayman’s PLA2 ELISA Kit is an immunometric (i.e. "sandwich") assay that can be used for the quantification of sPLA2 in plasma, synovial fluid, and other sample matrices. Each kit contains AChE:s PLA2 antibody conjugate, antiserum, human recombinant sPLA2 standard, Ellman’s...

Cayman’s PGE2 ELISA is a sensitive competitive assay that uses a high-affinity PGE2 monoclonal antibody for quantification of PGE2 in plasma, urine, and culture media samples.

An ATP-competitive inhibitor of several CDKs as well as GSK3β.

CAS Number: 1124197-58-5 Synonyms: Diflucan-d_4; Difluconazole-d_4; Fungicon-d_4; UK 49858-d₄ Molecular Formula: C₁₃H₈D₄F₂N₆O Formula Weight: 310.3

A potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM.

An HDAC inhibitor that selectively targets HDACs 4 and 5 (IC₅₀s = 12 and 4 nM, respectively) over other HDACs (IC₅₀s = 56, 320, 850, 880, and 1,280 for HDACs 6, 1, 11, 2, and 8, respectively); displays enhanced cytotoxic effects against human cancer cell lines, compared to SAHA...

A natural sesquiterpene lactone that reduces growth (EC₅₀ = 3-35 μM) and induces apoptosis in assorted cancer cell lines; inhibits the activation of Akt (15 μM) in endometriotic epithelial cells and STAT3 activation in THP-1 cells (EC₅₀ = 10 μM); inhibits telomerase...

A metabolite of a phosphotidylinositol ether lipid analog known to target the pleckstrin homology domain of Akt and to induce apoptosis in cancer cell lines with high levels of endogenous Akt activity.

A membrane-permeant, fluorescent Na+ indicator dye; increasing concentration of Na+ increases the ratio of excitation efficiency at 330-345 nm to that at 370-390 nm with emission collected at 450-550 nm.

An internal standard for the quantification of EPEA by GC- or LC-MS.

A selective inhibitor of human collagenase-3, also known as MMP-13, producing 89% inhibition at 10 µg/ml; used to evaluate the role of MMP-13 in diverse processes.

.DELTA.17-6-keto PGF1α is the non-enzymatic hydrolysis product of PGI3. PGI3 is a COX pathway metabolite of EPA in various tissues such as seminal vesicles, lung, PMNL, and ocular tissues.

A macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis; induces mitotic arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate,...

A potent pan-Aurora kinase inhibitor that favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM); inhibits proliferation of clear cell renal carcinoma (IC₅₀ = 2/M phase.

A selective inhibitor of JAK1 (IC₅₀ = 629 nM) that displays 30-fold selectivity for JAK1- over JAK2-dependent signaling in human whole blood; blocks IL-6/STAT1 and IL-2/STAT5 signaling in cell models and whole blood assays.

A selective, ATP-competitive inhibitor of CK2 with Ki values ranging from 0.5-1 µM.

Active enzyme for drug discovery research.

A selective agonist of β3-adrenergic receptors with Ki values of 0.43, 9.17, and 37.9 µM for β3, β2, and β1, respectively.

A coordinating solvent used to activate crystallization of chemical compounds; used in flame retardant applications, as an epoxy cure catalyst, and to produce nanostructures.

A potent, selective CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 37.9 and >10, 000 nM, respectively.

AMT is a potent, relatively selective inhibitor of iNOS with a Ki of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations; the IC₅₀ values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively.

A major arachidonic acid metabolite from the 15-LO pathway.

A specific ribonucleotide reductase inhibitor; inhibits growth of human promyelocytic leukemia HL-60 cells (IC50 = 35 µM).