Cayman Chemical

A small molecule that binds to the farnesyl-binding pocket of PDEδ (Kd = 41 nM) in cells thus inhibiting its interaction with KRAS and disrupting RAS signaling; reduces proliferation and increases cell death of Panc-Tu-I tumor cells at 5 μM in a human pancreatic ductal adenocarcinoma cell...

A synthetic catalytic scavenger of reactive oxygen species, with reduded activity compared to EUK 8 and EUK 134.

A certified reference material categorized as a cannabinoid; intended for research and forensic applications,

Antigen: synthetic peptides corresponding to amino acids 1-5, 433-448 and 467-482 of human HDAC1 Host: rabbit Cross-Reactivity: (+) human HDAC1 Application(s): WB

GSK2606414 is an orally available, selective protein kinase R-like ER kinase (PERK) inhibitor with an IC₅₀ value of 0.4 nM. It can inhibit thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells and attenuates subcutaneous pancreatic human tumor xenograft growth in mice....

A selective, high affinity ligand of the CB2 receptor (Ki = 0.6 nM v. CB1 binding at a Ki >10,000 nM in vitro) that may behave as an inverse agonist; displays antinociceptive activity in a formalin test in mice at a dose of 6 mg/kg.

A second messenger produced by bacteria but not by mammals; impacts bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions; triggers the expression of interferon genes in mammalian cells.

A potential prodrug analog of PGE2 with enhanced lipid solubility.

5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. It is 18 times more potent than PGE2 in activating adenylate cyclase in NCB-20 cell homogenates. 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated by...

An antiviral prodrug targeted against the influenza viruses; once hydrolyzed to its active metabolite, it can competitively inhibit viral neuraminidase (IC₅₀s = 0.1-4.9 nM for influenza neuraminidases A and B).

An inhibitor of p53-Mdm2 interaction (IC50 = 0.09 µM); induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53.

DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the...

An F-series PG analog approved for use as an ocular hypotensive drug under the Alcon trade name Travoprost.

Antigen: recombinant human Nod2 residues 28-301 Host: rabbit Application(s): WB and IP; may not detect basal levels of Nod2 in monocytes

Antigen: hamster brain SAF Host: mouse Isotype: IgG2b Cross Reactivity (PrPc): (+) hamster, mouse, bovine, ovine, and human PrP Application(s): WB

S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.

Racemic version of a CYP450 metabolite of AEA.

Contains four deuterium atoms at the 3', 3', 4', and 4' positions; is intended for use as an internal standard for the quantification of tafluprost by GC-or LC-mass spectrometry.

17-phenyl trinor PGF2α is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor. The ethyl amide analog has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. There is some evidence that unmetabolized...

LAEE is a neutral, more lipophilic form of the free acid that can be used as an exogenous source of α-linolenic acid (ALA). This ethanol metabolite may contribute to ethanol-induced hepatic fibrogenesis through stimulation of intracellular signaling pathways in hepatic stellate cells (HSC)....

The TXB2 Quant-PAK has been designed for the convenient, precise quantification of TXB2 by GC- or LC-MS. It includes a 50 µg vial of TXB2-d4 and a precisely weighed vial of unlabeled TXB2, with the precise weight (2-4 mg) indicated on the vial. This unlabeled TXB2 can be used to quantify the...

A natural benzoquinone which directly binds and inhibits XIAP (IC50 = 4.1 μM); blocks growth while activating caspases and promoting apoptosis in cancer cells expressing high levels of XIAP; prevents NF-κB activation by inhibiting IKK; protects against XIAP- and caspase-dependent...

A ring-opened analog of wortmannin that potently and irreversible inhibits PI3K (IC₅₀ = 0.1-88 nM); less potently blocks the activity of mTOR (IC₅₀ = 3.1 µM); exhibits single agent in vivo anti-tumor activity and increases the anti-tumor effects of cisplatin and radiation...

The racemic version of a CYP450 metabolite of arachidonic acid that dose-dependently stimulates vasodilation of the rabbit kidney.