Cayman Chemical

A potent and selective agonist of the human PGE2 receptor, EP4 with a Ki value of 0.38 nM and an EC50 value of 0.6 nM; induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein.

Antigen: synthetic peptide corresponding to amino acids 637-650 of human DNMT1 Host: mouse, clone 60B1220.1 Isotype: IgG1κ Cross Reactivity: (+) human, mouse, and zebrafish DNMT1 Application(s): ChIP, IHC (paraffin-embedded sections), IP, and WB DNMT1 is constitutively expressed in...

Strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM; can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.

AUDA is an inhibitor of sEH exhibiting IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively. In angiotensin-infused rats, a dose of 25 mg/l AUDA administered in drinking water decreased mean arterial blood pressure from 161 ± 4 mmHg to 140 ± 5 mmHg. This...

A prodrug for the active metabolite imidaprilat, an ACE inhibitor that suppresses the conversion of angiotensin I to angiotensin II (IC₅₀ = 2.6 nM), thereby preventing vasoconstriction and decreasing aldosterone secretion by the adrenal cortex.

Mitochondrial membrane potential, Δψm, is an important parameter of mitochondrial function that is used as an indicator of cell health. JC-1 is a lipophilic, cationic dye that can selectively enter into mitochondria and reversibly change color from green to red as the membrane potential...

A selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis (IC₅₀ = ~0.3 mM in HUVEC).

A mixture of lipids and nucleic acids produced during oxidative stress in biological systems; designed for direct use in LC-MS applications.

IPTU is a potent inhibitor of NOS in vitro but may lack good in vivo efficacy due to poor cellular penetration. The Ki values are 9.8, 22, and 37 nM using purified human iNOS, eNOS, and nNOS, respectively.

A prominent member of the N-arachidonoyl amino acyl amide family that activates both TRPV1 and TRPV4 with EC50 values of 28 and 21 µM, respectively.

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase (5-LO) pathway in leukocytes. LTC4, LTD4, and LTE4 are collectively referred to as cysteinyl leukotrienes (CysLTs). LTC4 and LTD4 are potent mediators of asthma and hypersensitivity....

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications

A potential thermal degradant of capsaicin with possible mutagenic effects.

Peroxidation of common ω-6 PUFAs such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted...

A minor CYP450 metabolite of arachidonic acid that potently inhibits proximal tubule ATPase activity.

A hybrid molecule patterned after N-arachidonoyl serotonin; effects of docosahexaenoyl serotonin are unknown.

A flavonoid isolated from the root of the traditional Chinese herb S. baicalensis with anti-inflammatory, antioxidant, antitumor, and neuroprotective activities at concentrations from 5-75 μM.

A cell-permeable derivative of 2-HG.

An internal standard for the quantification of PGD2 dopamine by GC- or LC-MS.

A mixed-type non-competitive inhibitor of telomerase (IC₅₀ = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase; induces senescence or apoptosis in cancer cells.

A synthetic intermediate useful for pharmaceutical synthesis.

A small molecule inhibitor of tankyrase 1 and 2 (IC₅₀ = 11 and 4 nM, respectively); increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin; inhibits colony formation of APC-deficient colorectal cancer cells at 0.33 µM.

A specific, cell-permeable inhibitor of S6K1 (IC₅₀ = 160 nM); does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity.

An inhibitor of S1P lyase; treatment of mice (50 µg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs, resulting in reversible lymphopenia.