AUDA is an inhibitor of sEH exhibiting IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively. In angiotensin-infused rats, a dose of 25 mg/l AUDA administered in drinking water decreased mean arterial blood pressure from 161 ± 4 mmHg to 140 ± 5 mmHg. This hypotensive effect was accompanied by an increase in urinary epoxide-to-diol ratios. AUDA activates PPARα 3-fold at a concentration of 10 µM but exhibits no affect on PPAR.delta. or PPARγ.