Cayman Chemical

A potent ATP-competitive inhibitor of Raf-1 in vitro (IC₅₀ = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells; activates the Raf-1 signaling pathway in human carcinoid tumor cells resulting in suppression of cellular proliferation.

A WDR5/MLL interaction inhibitor (IC₅₀ = 2.4 nM) that blocks MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis; inhibits cell growth and induces apoptosis in leukemia...

A potent, reversible, orally bioavailable inhibitor of Pim-1, -2, and -3 (IC₅₀s = 5, 25, and 16 nM, respectively); dose-dependently blocks the phosphorylation of the Pim targets Bad, 4E-BP1, and NKX3.1; acts synergistically with chemotherapeutic drugs.

A cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions; used in the composition of lipospomes formulated as SNALPs.

An internal standard for the quantification of (±)11(12)-DHET by GC- or LC-MS.

An alcohol related to a C32:6 very long chain fatty acid found in the retina; its biological actions are unknown.

A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription; inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.

An LPL activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle; decreases plasma triglyceride concentration and increases plasma high-density lipoprotein cholesterol, resulting in inhibited development of atherosclerotic lesions in coronary arteries and...

A classic, non-selective dopamine receptor agonist (pKis = 6.43, 7.08, 7.59, 8.36, and 7.83* for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively);produces biphasic effects on locomotor activity and displays anti-Parkinsonian and neuroprotective actions.

The 1,15 lactone of 17-phenyl-trinor PGF2α with potential for suitable pharmacologic activity and an improved side-effect profile over current glaucoma therapeutics.

A general competitive antagonist of mGlu receptors (KB values = 115, 88, and 77 µM for mGlu1a, mGlu2, and mGlu4a receptors, respectively).

A β-oxidation metabolite of LTB4.

Source: Human blood; all source material tested and found non-reactive to HTLV-III and HBsAg using FDA approved assay methods Mr: 38 kDa

A novel CB1 selective neutral antagonist with low CNS penetration (Ki = 1.7 and 523 nM for CB1 and CB2, respectively); reduces food intake, food-reinforced behavior and weight gain; improves metabolic profiles of mice with diet-induced obesity.

A potent, selective chemical probe for the methyl lysine reading function of L3MBTL3 (Kd = 120 nM; IC₅₀ = 40 nM) that competitively displaces mono- or dimethyl-lysine containing peptides.

A synthetic analog of PEA which incorporates an odd-numbered (17-carbon) fatty acid achain; potentiates the Ca2+ influx in response to AEA several fold in cells expressing human recombinant VR1.

A small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA-patient fibroblasts by 50% at 18 µM; increases phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.

15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE. Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established.

Antigen: human GPR120 amino acids 28-40 Host: rabbit Cross Reactivity: (+) human GPR120 Application(s): ELISA and WB

An inhibitor of SETD8 (IC₅₀ = 0.5 µM) that suppresses monomethylation of H4K20 in vitro; less potently inhibits Cdk4 (IC₅₀ = 6 µM for Cdk4/cyclin D1); suppresses the expression of Cdc7, resulting in an ATM-dependent checkpoint response and arrest of cell cycling in...

An inhibitor of HIF-1α protein translation; suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase; cytotoxic to a variety of cancer cell lines with an IC₅₀ value of 15-25...

A 16-membered macrolide used as an antibiotic in veterinary medicine; inhibits protein synthesis in bacteria and blocks the production of biofilms; particularly effective against Gram-negative pathogens (MIC = 0.25-1 µg/ml against P. multocida and M. haemolytica).

A glycoside isolated from plants used in Chinese medicine for a broad range of conditions; at 100 μM, significantly reduces apoptosis in response to H2O2 or cobalt chloride; protects mice from acetaminophen-induced toxicity.

A potent, reversible, and highly selective isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC₅₀ = 120 nM) and caspase-7 (Ki(app) = 170 nM); inhibits apoptosis in camptothecin treated Jurkat cells (IC₅₀ = ~50 µM) and in chondrocytes (44% inhibition at 10...