Cayman Chemical

ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC₅₀s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1,...

A highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM); acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα-, β1-, β2-, γ-, δ-, and ε-isozymes; inhibits GSK3 in primary adipocyte lysates...

A selective inhibitor of ERK2 (Ki 50 = 48 nM).

An internal standard for the quantification of 4(Z),7(Z),10(Z)-tridecatrienoic acid by GC- or LC-MS.

An amine-containing fluorescent probe that can be reversibly coupled to aldehydes and ketones on diverse molecules.

A broad-spectrum, indole-based antiviral compound that blocks viral fusion with target membranes, prohibiting viral entry into cells; effective against numerous viruses, including influenza A, B, and C and hepatitis B and C (IC₅₀s range from 3-12.5 µg/ml).

A first generation cephalosporin antibiotic that is broadly effective against gram-negative and gram-positive bacteria; mainly used in veterinary medicine for intramammary treatment of mastitis and intrauterine treatment of endometritis in cattle.

A potent activator of PKA (Ki = 30 nM) that is selective for PKA over PKG (Ki = 10 µM); resistant to degradation by cyclic nucleotide phosphodiesterases, displays good cell permeability, and prevents the aggregation of platelets stimulated with thrombin.

A deoxyhexose monosaccharide found on N- and O-linked glycans and glycolipids that exists either as a terminal modification of glycan structures or serves as a point of attachment for adding other sugars; plays a role in A and B blood group antigen substructure determination, selectin-mediated...

A xanthine derivative that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects; also inhibits mPGES-1 (IC₅₀ = 200 µM) and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells.

A cell permeable inhibitor of PKC with IC₅₀ values reported to range from 0.10 to 0.55 µM; designed to be more discriminative than its parent compound, the non-selective PKC inhibitor, staurosporine (Catalog No. 81590); also inhibits protein kinase A with IC₅₀ values...

PPARs are ligand-activated transcription factors belonging to the large superfamily of nuclear receptors. PPARα primarily activates genes encoding proteins involved in fatty acid oxidation, while PPARγ primarily activates genes directly involved in lipogenic pathway and insulin...

An inhibitor of Cdc7 kinase (IC₅₀ = 10 nM) as well as Cdk9, (IC₅₀ = 34 nM); induces apoptotic cell death in multiple cancer cell types at 10 µM.

A phospholipid containing 12:0 fatty acids at the sn-1 and sn-2 positions that exhibits excellent surfactant properties and may be useful for various applications.

A natural yellow carotenoid, which can be found in plants, egg yolks, and in the human retina; a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.

Cayman’s Acid Phosphatase Assay provides a convenient method for detecting AP activity in plasma, serum, urine, and semen. The assay utilizes para-nitrophenyl phosphate (pNPP) as a chromogenic substrate for the enzyme. In the first step, AP dephosphorylates pNPP. In the second step, the...

A plant growth regulator with anticancer activity.

An internal standard for the quantification of (±)14(15)-DiHET by GC- or LC-MS.

A selective EZH2 inhibitor (IC₅₀s = 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively); decreases cellular levels of H3K27me3 and H3K27me2 (EC₅₀s = 56 and 65 nM, respectively), triggering cell cycle arrest and ultimately resulting in apoptosis in a large...

An inhibitor of NHE1, NHE2, and NHE3 (Kis = 0.02, 0.25, and 14 μM, respectively).

The measurement of TG levels, in conjunction with other lipid assays, are useful in the diagnosis of primary and secondary hyperlipoproteinemia, dyslipidemia, and triglyceridemia. Cayman’s TG Assay provides a simple, reproducible, and sensitive tool for assaying TGs in plasma, serum, cell...

A selective inhibitor of TXA synthase (IC₅₀ = 11 nM).

FK-409 is a NO donor. It liberates NO in a time-dependent manner with a half-life of approximately 40 minutes in phosphate buffer (pH 7.4) at 37°C. The IC₅₀ for the inhibition of platelet aggregation is 4.9 µM.

methyl 2-Pyrimidine carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.