Cayman Chemical

A linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells; facilitates mazEF-mediated cell death, significantly reducing population size in E. coli cultures at 2.5 ng/ml.

A sulfhydryl-reactive biotinylation reagent that forms a reversible disulfide linkage, used to label protein cysteines and other substrates that contain sulfhydryl groups; easily linked with target substrates at pH 6.5 to 7.5 in buffers such as PBS; disulfide linkage can be cleaved by reducing...

A plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for ERα (IC₅₀ = 33.1 nM) and an agonist/antagonist for ERβ (IC₅₀ = 180.5 nM); demonstrates ionophorectic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria,...

An intermediate for the preparation of rac-7-hydroxy propranolol.

A potent inhibitor of ROCK-I and ROCK-II kinases (IC₅₀s = 6 and 4 nM, respectively).

The 16-carbon free fatty aldehyde analog of palmitic acid that, in conjunction with NAD+, acts as a substrate for hexadecanal:NAD+ oxidoreductase (fatty aldehyde dehydrogenase).

(±)12(13)-EpOME is the 12,13-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. The toxicity and biosynthesis of (±)12(13)-EpOME have not been well differentiated from (±)9(10)-EpOME, but have been presumed to be essentially the same.

ICI 192605 is a potent antagonist of the thromboxane A₂ receptor (TP) that blocks contraction of isolated guinea pig trachea induced by U-46619 (Item No. 16450; K_d = 0.398 nM). It is used to study the role of TP signaling in tissues and animals.

A potent, cell permeable inhibitor of PKC (IC50 = 660 nM); also inhibits BclXL function (IC50 = 1.5 μM), inducing apoptosis in several cancer cell lines; can have PKC-independent effects, activate p38 and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.

AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors. AH 6809 blocks the PGE2-induced accumulation of cAMP in COS cells transfected with the human EP2 receptor. It also blocks the accumulation of Ca2+ in Xenopus oocytes...

A selective TRPC3 inhibitor that prevents TRPC3-mediated Ca2+ influx (IC₅₀ = 0.7 μM) without effect on other TRPC members; suppresses activation of NFAT (IC₅₀ = 0.05 μM) and attenuates cardiac hypertrophy in mice at 0.1 mg/kg/day.

Carbaprostacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. This implies rapid metabolic inactivation of carbaprostacyclin. Carbaprostacyclin inhibits platelet...

Unoprostone is an analog of PGF2α with a 13,14-dihydro-15-keto modification and a two-carbon extension of the aliphatic lower side chain. The isopropyl ester of unoprostone (Catalog No. 16681) (Rescula) has been approved for clinical use as an ocular hypotensive drug.

A cell-permeant precursor of the fluorescent calcium indicator rhod-5N, a fluorescent calcium indicator that displays a low affinity for calcium (Kd = 19 µM).

A side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of SREBPs; has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor and immunomodulating activities.

Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe. CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to...

A synthetic auxin used as a supplement in plant cell culture media; an active ingredient in herbicides that controls root elongation and cell production by disrupting the actin cytoskeleton.

Inhibits squalene synthase activity in rat hepatic microsomes and human Hep-G2 cells (IC₅₀ values of 90 and 79 nM, respectively); inhibits cholesterol biosynthesis in rats reducing both cholesterol and triglyceride levels in plasma.

Treprostinil is a stable analog of prostacyclin (Item No. 18220) that is used clinically for the treatment of PPH under the trade name Remodulin™. The structural modifications in treprostinil compared to prostacyclin increase the plasma half-life from 2 minutes to 34 and 85 minutes for...

A stable analog of PGH2 that inhibits both PGI and TX synthases with more selectivity towards PGI synthase; a partial agonist at TP receptors.

A natural retinoid that associates with CRBP-I and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol; an intermediate of the phototransduction pathway of photoreceptors; can form toxic conjugates with proteins and lipids, leading to degeneration...

Source: Active human recombinant C-terminal His-tagged protein expressed in E. coli MW: 76 kDa Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues. The protein levels and enzymatic activity of 15-LO-2 are...

An agonist of the sigma-1 receptor (Ki = 10.4 nM); also binds the serotonin 5-HT3 and muscarinic acetylcholine receptors (Kis = 7.9 and 76 nM, respectively).

A metabolite of tamoxifen that has been shown to have a higher affinity for estrogen receptors compared to tamoxifen; demonstrates non-apoptotic cytotoxicity in HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines.