Cayman Chemical

An orally active, allosteric Akt inhibitor (IC50s = 5, 12, and 65 nM for Akt1, 2, and 3, respectively); inhibits cell proliferation of human cancer cell lines synergistically in combination with other topoisomerase inhibitors, antimetabolites, antimicrotubule agents, DNA cross-linkers or growth...

An inhibitor of USP14 and UCHL5, two proteasome-associated deubiquitinases; inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 µM; blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia.

A glycosphingolipid that contains two sialic residues linked to an inner galactose unit; component of plasma membranes that packs densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cell signaling events.

A derivative of testosterone and ethisterone that binds androgen receptors and sex hormone-binding globulin causing a 3-fold increase in free testosterone; possesses weak androgenic effects and inhibits the production of gonadotropins.

Unnatural C-15 epimer of Travoprost.

Lyso-PC is the ubiquitous lipid species generated following PLA2 hydrolysis of phosphatidylcholine. The hydrolysis of phospholipids by arachidonyl-selective PLA2s is the initiating event in many eicosanoid-based signal transduction pathways. Many other reactions also generate phosphatidylcholine...

A monoamine neurotransmitter produced in serotonergic neurons in the CNS and in enterochromaffin cells in the gastrointestinal tract that is important in the regulation of mood, sleep, vomiting, sexuality, and appetite.

A natural mycotoxin that binds filamentous actin (F-actin) and stabilizes actin fibers; commonly used to stain F-actin in cells when fluorescently labeled.

A potent inhibitor that blocks dopamine uptake (IC₅₀ = 1-51 nM); effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors.

α-CMBHC is the longer side-chain precursor of α-CEHC and a minor metabolite of α-tocopherol. HepG2 cells release α-CEHC, α-CMBHC, and α-CMHHC into the medium when treated with all rac α-tocopherol. Pretreatment of Hep-G2 cells with rifampicin, an inducer of...

A reversible inhibitor of both Aurora A and B kinases (IC₅₀s = 0.8 and 5 nM, respectively); also inhibits FLT1, FAK, TrkA, Met, and FGFR1 (IC₅₀s = 10, 22, 30, 100, and 100 nM, respectively).

Endogenous ligand of the APJ receptor, with an EC50 of 0.37 nM; acts primarily in the periphery and CNS, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity.

Contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions; intended for use as an internal standard for the quantification of SAPC by GC- or LC-MS.

A metabolite produced during GCDH deficiency and used as a biomarker of glutaric acidemia type 1.

An inhibitor of the CBP and p300 bromodomains (IC₅₀s = 125 and 363 nM, respectively).

A liver-specific inverse agonist of the two LXR isoforms, LXRα and LXRβ (IC₅₀s = 214 and 43 nM, respectively); suppresses hepatic lipogenesis, inflammation, lipid accumulation, and fibrosis in mouse models of non-alcoholic steatohepatitis.

An indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in HL-60 cells; does not prevent etoposide-induced apoptosis or inhibit PKC or S6K1.

V-PYRRO/NO is a NO donor in vivo. Following hepatic metabolism, it spontaneously decomposes with a half-life of 3 seconds to liberate NO.

A selective inhibitor of PDGF receptor kinase with an IC50 value of20 µM in human bone marrow; inhibits the EGF receptor with an IC50 value of 820 µM.

A cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 µM for PLAP and NSAP, respectively); also used as a tyrosine phosphatase inhibitor.

Used to prepare various neoglycoproteins, which consist of a glycosylated serum albumin substituted with either fluorescein or methotrexate.

Cayman’s Renin Inhibitor Screening Assay provides a convenient assay in a 96-well format for evaluating human renin inhibitors. The assay utilizes a renin-based synthetic peptide substrate which incorporates the fluorophore EDANS at one end and an EDAN-quenching molecule (Dabcyl) at the other...

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications

A selective inhibitor of PI3Kα that is equipotent against both wild type and several mutant isoforms (IC₅₀s = 4.0-4.8 nM); dose-dependently inhibits the growth of PI3Kα-dependent xenograft tumors in mice, alone or in combination with other kinase inhibitors.