Cayman Chemical

A cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.

Indomethacin is a COX inhibitor that prevents ex vivo TXB2 formation and other PGs that can not be prevented using anticoagulant alone. The samples have to be transferred in indomethacin sampling tubes as soon as possible after blood collection.

15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.

13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor. It also inhibits ion flux in a canine colonic mucosa preparation. In humans,...

An activator of apoptosis through UPR.

A fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans.

An inhibitor of PP2A and PP4 (IC₅₀s = 3.2 and 3 nM, respectively); less effectively inhibits topoisomerase II and PP1 (IC₅₀s = 40 and 131 μM, respectively) and does not inhibit PP2B.

Vasicinone is a quinazoline alkaloid that can be isolated from A. vasica leaves and demonstrates bronchodilatory activity. It also is reported to possess antioxidant activity in nitric oxide and ABTS radical scavenging assays.

A competitive inhibitor of nucleotide binding by Ras-related GTPases; binds Rab7 (Ki = 13 nM), preventing BODIPY-linked GTP and GDP binding with EC₅₀ values of 11.2 and 21 nM, respectively.

A potent, selective DP1 receptor antagonist that binds DP1 and DP2 receptors with Ki values of 0.57 nM and 0.75 µM, respectively.

A potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family; inhibits Abl, Src, and Lck with IC50 values of 0.05, 0.5, and 0.4 nM, respectively; has potential therapeutic value in some forms of cancer and fibrotic disease.

Antigen: synthetic peptide from human androgen receptor amino acids 207-221 Host: mouse, clone 156C135.2 Cross Reactivity: (+) human and monkey androgen receptor Application(s): WB and IHC (paraffin-embedded)

A cyclic thiopeptide antibiotic first isolated from S. bernensis; inhibits protein biosynthesis in Gram positive bacteria through binding with ribosomal subunits; induces the transcriptional activator TipA in Streptomyces.

11-keto Fluprostenol is an analog of PGD2 with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto...

A pyridopyrimidine-type inhibitor of receptor tyrosine kinases that inhibits c-abl (IC₅₀ = 8 nM) and Bcr/Abl-dependent cell growth (IC₅₀ = 0.4 nM); also potently inhibits c-src (IC₅₀ = 6 nM); effectively blocks Bcr/Abl kinase activity in vivo.

cis-4,10,13,16-Docosatetraenoic acid is a long chain PUFA. It is a minor fatty acid component of rat testis lipids.

A calcium channel blocker.

Antigen: human Trx1 Host: mouse, clone 2G11 Isotype: IgG1 Application(s): ELISA, IF, IP, and WB

Peptide Sequence: human, rat, and mouse CB1 receptor sequence amino acids 1-14 (MKSILDGLADTTFR) To be used in conjunction with Cayman’s CB1 receptor polyclonal antibody (Catalog No. 101500) to block protein-antibody complex formation during analysis for the CB1 receptor. The CB1 receptor and...

A physically smaller, less hydrophobic version of the lidocaine derivative QX314 designed to be more permeable to the TRPV1 ion channel for selective analgesia through TRPV1.

Potassium chloride stock solution (1 M) contains filtered potassium chloride (1 M). It is ready to use as supplied.

An angiotensin metabolite that functions as a type 1 angiotensin II receptor agonist whereupon it can control hydroelectrolyte balance and demonstrates vasodilatory and anti-inflammatory actions in opposition to various adverse effects of angiotensin II.

A FAHFA in which palmitic acid is esterified to 9-hydroxy stearic acid; abundant in serum as well as white and brown adipose tissues of glucose tolerant AG4OX mice; improves glucose tolerance, stimulates insulin secretion, and has anti-inflammatory effects in mice.

A triazole antifungal agent that is effective against most Candida strains.