Cayman Chemical

DPI is an irreversible inhibitor of iNOS and eNOS with IC₅₀ values of 50 nM and 0.3 µM, respectively. This inhibition is potent, irreversible, and time and temperature dependent. NADPH, NADP+, and 2'5'-ADP block the inhibitory action of DPI. Similarly, FAD or FMN protect NOS...

A β-lactam antibiotic that lyses actively-growing E. coli by binding specifically to penicillin-binding proteins 1a and b whose transglycosylase and transpeptidase activities are involved in cell elongation and septation.

A cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity; inhibits mouse macrophage metalloelastase MME/MMP-12 (IC₅₀ = 13 nM).

An analog of forskolin that interacts with, but does not activate, adenylyl cyclase.

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Tyr1336 of the human NMDA Receptor NR2B Subunit Host: rabbit Cross Reactivity: (+) human and rat NMDA receptor; expected to react with bovine, canine, chicken, mouse, non-human primates, and zebrafish NMDA receptor...

A selective inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC₅₀ value of 9.8 nM; inhibits Mer activity in cells and displays good pharmacokinetic properties in mice following intravenous or oral administration.

20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4. LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4...

The 8-iso-PGF2α Quant-PAK has been designed for the convenient, precise quantification of 8-iso-PGF2α by GC- or LC-mass spectrometry. It includes a 50 µg vial of 8-iso-PGF2α-d4 and a precisely weighed vial of unlabeled 8-iso-PGF2α, with the precise weight indicated on...

An internal standard for the quantification of 9-PAHSA by GC- or LC-MS.

Immunogen: Purified recombinant human MAGL Host: rabbit Species Reactivity: (+) human and rat MAGL Applications: IF, IHC, and WB

Peptide contains a trimethylated lysine residue at position nine which is a substrate for several of the JMJC domain-containing class of histone demethylases; JMJD2A and JMJD2D exhibit higher affinity with H3K9me3 compared to H3K9me2.

An ester version of DHA free acid which is less water soluble, but more amenable for the formulation of fatty acid-containing diets and dietary supplements.

A major CYP450 metabolite of arachidonic acid that is released from the kidney in response to angiotensin II; a potent vasodilator of renal preglomerular vessels.

It has been reported that AEA can be used directly by COX-2 and specific PGH2 isomerases to produce ethanolamide congeners of the classical PGs, including PGF2α.{2415} PGF2α ethanolamide has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and...

A small molecule inhibitor of KCNJ1 (IC₅₀ = 294 nM) which also causes 70% inhibition of KCNJ13 at 10 µM; has no effect on the related channels KCNJ2 (Kir2.1) and KCNJ10 (Kir4.1) at a concentration of 10 µM.

An agonist of GPR199 that is effective both in isolated cells and in vivo; increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 μM) and promotes glucose-stimulated insulin secretion in mice (100 mg/kg).

A photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.

N-4AIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4AIA inhibits human recombinant and ovine COX-2 with IC₅₀ values of 0.1 and 0.625 µM, respectively. It is about 80 times less potent as an inhibitor of...

Antigen: human and rat amino acids 130-149; The sequence is 95% homologous to 5-LO from mouse and hamster Host: rabbit Cross Reactivity: (+) human, rat, mouse, hamster, and porcine 5-LO; (−) 12-LO and 15-LO Application(s): WB 5-LO catalyzes the formation of 5(S)-HpETE from arachidonic acid as...

A selective, ATP-competitive inhibitor of Clk4 (IC₅₀ = 136 nM).

Neutrophil elastase is stored within cytoplasmic azurophilic granules in the neutrophil and released upon stimulation by pathogens where it acts either as free protein or is associated with networks of extracellular traps (NET). Together with other proteases released from activated neutrophils,...

(±)12(13)-DiHOME-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of (±)12(13)-DiHOME by GC- or LC-mass spectrometry (MS).

A selective Bcr-Abl tyrosine kinase inhibitor.

19(R)-Hydroxylated PGs occur in µg/ml concentrations in the semen of certain mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R). 19(R)-Hydroxylated PGs are also found in the seminal...