Cayman Chemical

Source: 50 µg of a complex of full length recombinant C-terminal His-tagged HDAC3 and recombinant N-terminal GST-tagged NCOR2 amino acids 395-489, co-expressed in baculovirus expression system Mr: 49.7 kDa (HDAC3); 37.6 kDa (NCOR2) HDAC3 is a Class I HDAC that is inactive alone and requires...

An internal standard for the quantification of PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt) by GC- or LC-MS.

Glucose-6-phosphate (G6P) plays a key role in the homeostatic regulation of blood glucose levels by participating in glycolysis, glycogen synthesis, gluconeogenesis, and can be metabolized to NADPH, enabling protection against oxidative damage. Disruption of G6P activity leads to glycogen storage...

An irreversible inhibitor of BTK (IC₅₀ = 0.5 nM) that selectively blocks B cell activation, promoting apoptosis and preventing homing to the protective tumor microenvironment, at concentrations that do not affect T cell receptor signaling (1,000-fold more potent); studied clinically for...

Features a biotin group and propanoic acid separated by a disulfide linkage; allows biotinylation of targets through either a chemical or enzymatic acylation reaction; disulfide bond permits removal of the biotin group with reducing agents.

A polycationic dye that inhibits sarcoplasmic reticulum Ca2+ release, blocks Ca2+ uptake and release from mitochondria, and prevents Ca2+ release from ryanodine-sensitive intracellular stores in skeletal and cardiac muscle (Kis = 16 nm - 5.9 μM, depending on Ca2+ concentration).

YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis. YLF-466D activates AMPK at a concentration of 150 µM in platelets. It inhibits platelet aggregation induced by thrombin, ADP, and collagen...

A cell-permeant inhibitor of pre-mRNA splicing.

cAMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression.

A selective, irreversible propargylamine inhibitor of MAO-B (IC₅₀s = 4.43 and 412 nM for MAO-B and MAO-A, respectively) that has been used to increase the availability of dopamine at striatal receptors as a strategy to treat Parkinson’s disease.

A phospholipid containing the long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions.

An antagonist of cIAP1, cIAP2, and XIAP.

An inhibitor of NF-κB, blocking its translocation into the nucleus (IC₅₀ = 7.1 µM); does not affect degradation of IκB; interferes with NF-κB-mediated gene expression and apoptosis in RAW 264.7 cells treated with LPS.

Magnesium chloride stock solution contains filtered magnesium chloride (1 M). It is ready to use as supplied.

A mixture of 5-carboxy and 6-carboxy derivatives of fluorescein; used to label biomolecules through a reaction involving the carboxyl group; membrane impermeant, with applications in studies of membrane permeability.

A potent and selective CB1 receptor antagonist/inverse agonist (Ki = 12 and 4,200 nM for CB1 and CB2, respectively)

Recombinant C-terminal His-tagged protein expressed in E. coli One unit is defined as the amount of enzyme required to reduce 1 µmol of NADP+ to NADPH per minute at 25°C in 50 mM Triethanolamine, pH 7.6, containing 1 mM MgCl₂.

AGGC is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated...

A red dye that can be used as an alternative to Gram staining; inhibits MRSA growth in vitro at 100 µg/ml; modulates channel activity of wild-type CFTR (Ki = 38 µM) and mutant delta F508 CFTR (Ki = 33 µM).

An orally available, reversible inhibitor of Akt (Ki = 11 nM for Akt1); also inhibits PKA and Cdk2 with IC₅₀ values of 16 and 46 nM, respectively; reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells both in vitro and in vivo.

A fluorogenic substrate for triglyceride lipases that is amenable to high-throughput analyses.

An F-series PG analog which has been approved for use as an ocular hypotensive drug; the ree acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.

An internal standard for the quantification of arachidonic acid by GC- or LC-MS.

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser41 of Gap-43 Host: rabbit Cross Reactivity: (+) rat Gap-43; expected to react with bovine, canine, chicken, finch, human, mouse, non-human primates, Xenopus, and zebrafish Gap-43 Application: WB