Cayman Chemical

A potent and selective inhibitor of type 3 PDEs, inhibiting recombinant PDE3A and PDE3B with IC₅₀ values of 0.45 and 1.0 μM, respectively; has positive inotropic (stimulates cardiac muscle contractions) and vasodilatory effects when administered in vivo.

Antigen: recombinant human renin protein Clone designation: 3G10 Host: mouse Cross Reactivity: (+) human Isotype: IgG2b Application: (+) IP; (-) WB

An inhibitor of Nav, blocking human Nav1.2, Nav1.5, and Nav1.8 with IC₅₀ values of 10, 62, and 96 μM, respectively.

Isoxyl is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 µg/ml. At concentrations of 10...

A phospholipid containing palimitoyl (16:0) and oleoyl (18:1) acyl substituents at the sn-1 and sn-2 positions, respectively, that been used to generate lipid membrane bilayers with controlled permeability and may be useful for various surfactant applications.

Molecular Formula: C₁₇H₁₄N₂O₂S

An essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain; constitutes as much as 40% of the total PUFA pool in retinal and neuronal membranes; dietary supplementation via fish oil inhibits the progression of atherosclerosis and delays...

Cayman’s HDAC1 Inhibitor Screening Assay provides a fast, fluorescence based method for screening HDAC1 inhibitors. The procedure requires only two easy steps, both performed in the same microplate. The fluorescent reaction product is analyzed using excitation wavelengths between 340-360 nm...

A potent, selective, and orally available inhibitor of Pim kinase (IC₅₀s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively); causes cell cycle arrest and apoptosis in MOLM-16 cells and inhibits the growth of MOLM-16 xenograft tumors in mice.

A fluorophore used to monitor functional activity of CYP1A1, CYP2B4, and CYP2B6; excitation/emission maxima equals 318 and 377 nm, respectively in methanol and 360 and 449 nm, respectively in dealkylase.

The inactive enantiomer of the SET7/9 inhibitor (R)-PFI-2 that may serve as a negative control.

C-6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C-2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides. C-6 ceramide mediates many diverse biological activities including apoptosis,...

A minor component of avermectin broth, used broadly against nematodes, ticks, flies, and ants.

A water soluble and metabolically stable curaxin that activates p53 with an EC₅₀ value of 0.37 µM and inhibits NF-κB with an EC₅₀ value of 0.47 µM; has broad anticancer activity in mice when administered orally.

Potent, cell permeable inhibitor of PHD2 (IC50 = 21 nM) with over 100-fold selectivity compared to inhibition of JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH (IC50s > 100 μM); inhibits HIF-1α hydroxylation in RCC4 cells at 50 μM.

A natural antifungal phytotoxin that selectively and potently inhibits fungal Pkc1, which are central to cell wall integrity (IC₅₀ = 25 nM for Candida Pkc1); potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC₅₀ = 115 and 11 nM, respectively), reducing protein...

A first generation tricyclic antidepressant; blocks the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively); inhibits 5-HT2A receptor (Ki =20 nM); antagonizes histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively).

A S-nitrosothiol that acts as an NO donor under acidic conditions; decomposes with a half-life of 15 minutes in 0.1 M phosphate buffer, pH 5.0, at 37°C; relaxes phenylephrine-constricted rat aortic strips 63% and 37% at pH 6.0 and 7.4, respectively.

A mono hydroxy fatty acid derived from of 11Z,14Z-eicosadienoic acid in an LO-type reaction catalyzed by COX; spectrophotometric measurement of the conjugated diene is occasionally used to quantify COX activity.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor gamma (NR1C3), a ligand-dependent transcription factor commonly referred to as PPARG or PPARγ....

Features Each vial contains a mixture of standards packaged in amber ampules purged with argon >1 ml provided at the concentration specified in the insert Designed for direct snap and inject use in mass spectrometry applications Ideally suited for method development and as a system suitability...

Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that...

Antigen: full length, human recombinant cPGES Host: rabbit Cross-Reactivity: (+) human and mouse cPGE synthase; (−) mPGES-1 and -2 Application(s): WB and ICC

An inhibitor of DGK (Ki = 3.1 µM) and DGAT (IC₅₀ = 5.6 µM); reduces the concentration of phosphatidic acid in T cell lymphoma (IC₅₀ = 3 µM); binds to human CCR5 chemokine receptors with an IC₅₀ value of 11 µM.