Cayman Chemical

Source: recombinant N-terminal GST-tagged protein purified from E. coli Mr: ~45.2 kDa (18.9 kDa native; 26.3 kDa GST-tagged) PtdIns-(4,5)-P2 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2. PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide...

A selective, small molecule inhibitor of PIP5K1C (IC₅₀ = 41 nM, Kd = 51 nM); decreases PIP2 membrane levels in cultured DRG neurons by 45%, significantly reducing calcium signaling; displays antinociceptive effects in mouse models of chronic pain.

A PDE5A inhibitor (IC₅₀ = 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosine via red blood cells; scavenges the free radicals that inactivate COX, leading to the inhibition of platelet activation and thrombin generation; also...

A water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously; stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms; relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.

Racemic version of a CYP450 and epoxide hydrolase metabolite of EPA.

A dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle; recognized as a non-selective channel blocker.

An antipsychotic, thienobenzodiazepine compound that binds as an antagonist/inverse agonist to dopamine D1 (Ki = 31 nM), dopamine D2 (Ki = 11 nM), dopamine D4 (Ki = 27 nM), serotonin 5-HT2A (Ki = 4 nM), serotonin 5-HT2C (Ki = 11 nM), serotonin 5-HT3 (Ki = 57 nM), muscarinic M1 (Ki = 2 nM),...

A deacetylated analog of cytochalasin H that weakly inhibits actin assembly but significantly alters mitotic spindle microtubule organization and kinetochore structure; suppresses the production of reactive oxygen species by stimulated human neutrophils.

An internal standard for the quantification of voriconazole by GC- or LC-MS.

A low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.

A chromogenic substrate for many PLA2s including sPLA2, cPLA2, and iPLA2.

Source: Recombinant N-terminal His-tagged protein expressed in E. coli Mr: 16.6 kDa The isolated individual or tandem bromodomains of BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.

Cayman's Adipolysis Assay Kit provides a complete assay for studying the lipolysis of triglycerides, from the differentiation of adipocyte-like cells to the quantitation of released glycerol. 3T3-L1 cells are differentiated using a common adipogenesis induction procedure to accumulate lipid...

A selective inhibitor of the TGF-β type 1 receptor ALK5 (IC₅₀s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively); used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2...

A metabolism resistant analog of PGA1

Source: Active recombinant N-terminal His-tagged protein expressed in Sf21 cells Mr: 96.3 kDa Recombinant Gcn5 preferentially acetylates lysine 14 on histone H3 in vitro; however, alone it is unable to acetylate nucleosomal core histone substrates. Acetylation of the nucleosomal histones requires...

An ester version of the free acid that may be more amenable for the formulation of fatty acid-containing diets and dietary supplements.

A side-chain substituted oxysterol that has important roles in cholesterol homeostasis; potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes.

An antioxidant and free radical scavenging compound extracted from S. miltiorrhiza that has been investigated for its cardioprotective and chemopreventative properties.

A synthetic form of the natural hormone; used to treat hypothyroidism.

A small diffusible signaling molecule secreted by various bacteria; produced via lactonolysis from 3-oxodecanoyl-homoserine lactone.

An acetylated form of L-carnitine that facilitates the uptake of acetyl CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis.

A sulforaphane analog found in cruciferous vegetables that demonstrates potent anti-inflammatory effects; doubles the phase II enzyme quinone reductase activity in mouse hepatoma cells at 1.7 µM; inhibits degradation of IκBα, NF-κB p65 translocation to the nucleus, IRAK...

A 1,2-dicarbonyl compound originating from the degradation of galactose; can be formed by Maillard or caramelization reactions.