Cayman Chemical

A reversible inhibitor of the auto and transphosphorylation kinase activity of the ErbB receptor tyrosine kinase superfamily: EGFR (IC₅₀ = 8 µM), ErbB-2 (IC₅₀ = 49 nM), ErbB3, and ErbB4 (IC₅₀ = 52 nM); induces G1 cell cycle arrest in MCF10A breast cancer cells.

Selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM); reduces intestinal fluid secretion induced by cholera toxin; effective in cells in culture and also in nasal and intestinal epithelia in vivo.

A tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors: H1 (Kd = 0.27 nM), 5-HT2A, α1-adrenergic, D2 (Kd = 180 nM), muscarinic acetylcholine (Kd = 58 nM), 5-HT2C, D1, and α2-adrenergic (Kd = 680 nM) receptors.

An inhibitor of protein synthesis in eukaryotes (IC₅₀ = 5-50 μM) that functions by interfering with translational elongation; can either induce or inhibit apoptosis depending on cell type.

A glucocorticoid steroid that activates the glucorcorticoid receptor with an EC₅₀ value of 12.4 nM; reduces inflammation and has utility in inflammatory diseases, like asthma and inflammatory bowel disease; may be abused by athletes.

Water used for the preparation of EIA reagents and buffers.

A certified reference material that is structurally similar to known phytocannabinoids; has been found as a byproduct in Cannabis processing; regulated as a Schedule I compound in the United States; provided as a DEA exempt preparation

Foretinib is a broad-spectrum tyrosine kinase (TK) inhibitor that targets members of the HGF and VEGF receptor TK families, as well as KIT, Flt-3, PDGFRβ, and Tie-2, at nanomolar concentrations. It blocks HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation, preventing...

Maresins (macrophage mediators in resolving inflammation) are members of a class of potent anti-inflammatory and pro-resolving mediators that are synthesized by macrophages in the presence of DHA. MaR1 is produced via oxidation of endogenous DHA by 12-LO. MaR1 has been shown to reduce neutrophil...

A FAHFA consisting of palmitoleic acid esterified at the 12th carbon of stearic acid; significantly elevated in serum of glucose tolerant AG4OX mice; may be a bioactive lipid with roles in metabolic syndrome and inflammation.

The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including, neurodegeneration and aging, cancer, and infectious diseases. There are a number of fluorescent reagents that can be used to detect free radicals, such as...

TTP 22 is a thienopyrimidine compound that inhibits casein kinase 2 (CK2) with an IC₅₀ value of 100 nM (Ki = 40 nM). It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM.

Antigen: human GPR31 amino acids 288-298 Host: rabbit Cross Reactivity: (+) human GPR31 Application(s): ELISA, ICC, and WB

A selective inhibitor of PAD4 (IC₅₀ = 200 nM in the absence of calicum); inhibits the citrullination of PAD4 target proteins and diminishes NET formation in mouse neutrophils.

An antifungal imidazole that inhibits a broad range of pathogenic yeasts and molds, including A. fumigatus, C. neoformans, C. albicans, and T. mentagrophytes.

A selective inverse agonist of ERRα (IC₅₀ = ~300-500 nM); blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of MAO A and B; induces proteasomal degradation of ERRα and potentiates the degradation of ERα by fulvestrant.

A potential impurity in the production of commercial lots of bulk arbaprostil.

Source: Active recombinant N-terminal His-tagged protein expressed in Sf21 insect cells MW: 118.3 kDa

A potent and selective CRTH2/DP2 receptor agonist, that is equipotent with PGD2 at this receptor.

A natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.

Antigen: human PTEN amino acids 254-270 Host: rabbit Cross Reactivity: (+) human, mouse, chimpanzee, canine, and rat PTEN Application(s): WB and IHC (paraffin-embedded sections) PTEN dephosphorylates proteins and lipids such as Akt and PIP3 and therefore functions as a key regulatory enzyme in a...

PGE1 is the theoretical COX metabolite of DGLA, but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC₅₀ of PGE1 for the inhibition of ADP-induced human platelet...

5(Z),11(Z),14(Z)-Eicosatrienoic acid is a PUFA found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods. A diet containing MPSO lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was...

A potent, selective inhibitor of mTOR.