Cayman Chemical

A centrally acting α2-adrenergic receptor agonist that decreases peripheral vascular resistance by centrally inhibiting sympathetic nerve activity; also acts as an agonist of the imidazoline (I1) receptor (Ki = 4-8 nM).

An isomer of cyclosporin A that forms upon acid hydrolysis or upon ionization during MS.

Antigen: synthetic peptide from the human mPGES-2 sequence conjugated to KLH amino acids 221-235 Host: rabbit Cross-Reactivity: (+) human, mouse, rat, ovine, bovine, and Cos-7 (African green monkey) mPGES-2; suspected positive with macaque but not yet tested (−) mPGEs-1, cPGES Application: WB

A precursor that is used in the synthesis of HMG-CoA; also used in the synthesis of 3-alkyl-3-hydroxyglutaric acids that act as inhibitors of HMG-CoA reductase.

Potassium Phosphate Stock Solution (500 mM, pH 8.0) contains filtered sodium phosphate (500 mM, pH 8.0). It is ready to use as supplied.

A natural oxidative metabolic product of the mycotoxin aflatoxin B2.

An HDAC inhibitor that has an optimal effective concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems; induces cell cycle arrest in cancer cells in vitro and in vivo; facilitates the cloning of inbred mouse strains...

The primary oxygenation product of DHA when exposed to aspirin-inhibited COX-2; serves as a precursor to resolvins and has intrinsic biological activity, such as the inhibition of TNF-α-induced IL-1β expression in human glioma cells.

A divalent cation ionophore, commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways; also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.

A saturated DAG with myristic acid (14:0) side-chains attached at both the sn-1 and sn-2 positions.

The biological effects of PGD2 (Item No. 12010) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and DP2/CRTH2. BAY-u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of the...

An alkaloid that irreversibly inhibits both human VMAT1 and VMAT2 (Ki = 34 and 12 nM, respectively); used to experimentally deplete monoamines in animals; also inhibits P-glycoprotein (IC₅₀ = 0.5 µM).

An inactive control analog of reversine.

A stable, cell-permeable dye employed to assay cell proliferation as it is partitioned with high fidelity between daughter cells for up to eight generational divisions.

A quinazoline that inhibits the tyrosine kinase activity of EGFR (IC₅₀ = 0.025 nM); inhibits the growth of SKOV3 and MDA-468 tumor cell lines (EC₅₀s = 6.5 and 30 µM, respectively).

A potent ceramidase inhibitor that induces apoptosis in human colorectal cancer, keratinocyte, and melanoma cell lines; produces approximately 50% cell non-viability at 10 µM and >80% cell death at 100 µM.

A form of FAHFA in which oleic acid is esterified to 9-hydroxy stearic acid.

An F-series PG analog in which the C-1 carboxyl group has been modified to an N-diethyl amide; dialkyl amides such as a 17-p-PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids.

A potent HDAC8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively); induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4 μM).

An inhibitor of stearoyl-CoA desaturase that selectively eliminates hPSCs (EC₅₀ = 2 µM) while sparing progenitor and differentiated cells; developed as a strategy to prevent tumorigenic risk from residual undifferentiated cells used during stem cell therapy.

A selective FFAR1 (GPR40) agonist (EC₅₀ = 26 nM) that does not exhibit activity on the related FAARs FFAR2 (GPR43) or FFAR3 (GPR41).

An antimicrotubule agent that binds to β-tubulin with a similar order of magnitude as the binding of paclitaxel to β-tubulin (IC₅₀s = 2.3 and 3.6 µM, respectively); cytotoxic to human T-24 bladder carcinoma cells (IC₅₀ = 0.05 µM in vitro).

An enantiomer of C75, which in racemic form is a stable FAS inhibitor that when administered leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.