Cayman Chemical

A membrane-impermeable calcium chelator that binds extracellular calcium ions.

A potential metabolite of 17-phenyl trinor PGF2α ethyl amide when administered to animals.

A nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases; inhibits bone resorption in vitro with an IC₅₀ value of 2 nM.

16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2. It enhances ADP-induced human platelet aggregation and increases systemic blood pressure in rats.

A flavonol that selectively inhibits Pim-1 (IC₅₀ = 0.34 µM) compared to Pim-2, PKA, RSK2, and JNK (IC₅₀s = 3.45, 21.2, 2.82, and 4.6 µM, respectively); inhibits Pim-1 activity in intact RWPE2 prostate cancer cells (ED₅₀ = 5.5 µM) significantly...

A cephalosporin antibiotic with potent in vitro activity against streptococcal species, including S. aureus (IC₅₀ = 2 µg/ml) and penicillin-resistant S. pneumonia and also effective against a wide range of other β-lactamase-producing bacterial species (MIC90s = 0.01 - 130...

One of several nitroaniline fatty acid amides that can be used to measure FAAH activity; exposure to FAAH results in the release of the yellow colorimetric dye m-nitroaniline (ε = 13,500 at 410 nm) allowing for fast and convenient measurement of FAAH activity using a 96-well plate...

Source: human recombinant N-terminal His-tagged protein expressed in E. coli Mr: ~60 kDa PPARs are members of the nuclear receptor family of ligand activated transcription factors that heterodimerize with retinoic acid like receptors, regulating gene expression and differentiation. PPARγ has...

6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM...

A reversible inhibitor of Tpl2.

The methyl ester of an unusual PUFA generated during the synthesis of DHA-d5.

A potent PLD2 inhibitor, both in vitro (IC₅₀ = 140 nM) and in cells (IC₅₀ = 110 nM); also effective as a PLD1 inhibitor at higher concentrations (IC₅₀ = 5.1 μM in vitro, 1.0 μM in cells); strongly inhibits the invasive migration of breast cancer cells in...

Lipid peroxidation is a well-established mechanism of cellular injury in both plants and animals and is used as an indicator of oxidative stress in cells and tissues. Lipid peroxides, derived from polyunsaturated fatty acids, are unstable and decompose to form a complex series of compounds, which...

A diterpenoid related to phorbol that activates PKC (Ki = 30 μM; ED₅₀ = 27 μM) and promotes tumor formation.

A synthetic intermediate useful for pharmaceutical synthesis.

Antigen: human NF-κB (p65) amino acids 526-539 Host: mouse, clone 112A1021 Isotype: IgG1κ Cross-Reactivity: (+) human, mouse, and rat NF-κB (p65); expected to react with bovine, gorilla, monkey, and porcine NF-kB (p65) Application(s): FC, IHC, and WB The active nuclear form of the...

A tertiary amine that complexes with, and stabilizes, Cu(I) to accelerate azide-alkyne cycloadditions, as used in click chemistry.

The detection and measurement of free thiols (i.e., free cysteine, glutathione, and cysteine residues on proteins) is one of the essential tasks for investigating biological processes and events in many biological systems. Cayman’s Thiol Detection provides a simple, reproducible, and sensitive...

A potent competitive inhibitor of PKC, PKG, and PKA with Ki values of 18, 0.87, and 1.9 µM, repectively.

A “hybrid” analog which incorporates components of both the AEA-like and dopaminergic neurotransmitter pathways; is nearly inactive as a TRPV1 ligand and fails to elicit hyperalgesic or nocifensive responses in vivo; exhibits an “entourage” effect at concentrations of 0.1-10...

A selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM); evokes RORα-dependent effects both in vitro and in vivo.

An internal standard for the quantification of PtdIns-(3)-P1 (1,2-dipalmitoyl) (ammonium salt) by GC- or LC-MS.

5(6)-EpETE methyl ester is a derivative of 5(6)-EpETE which is stable enough to ship and handle routinely. 5(6)-EpETE methyl ester is a chemically less reactive derivative of 5(6)-EpETE. The active free acid can be generated from the methyl ester by careful base hydrolysis. Epoxy eicosatetraenoic...

A non-competitive inhibitor of γ-glutamyl transferase (GGT), exhibiting a Ki value of 17.6 μM; less toxic than the GGT inhibitor acivicin toward dividing cells.