Cayman Chemical

A citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC₅₀s = 139-188 μM); demonstrates antifibrotic, lipid lowering, and insulin-like properties.

A potent inhibitor of acid sphingomyelinase (IC₅₀ = 20 nM); completely inhibits dexamethasone-induced apoptosis in HepG2 cells; more than 5,000 times more selective for acid sphingomyelinase than for the Mg2+-dependent neutral sphingomyelinase (IC₅₀ > 100 μM).

An analog of fluprostenol 2-glyceryl ester with increased stability.

A tyrphostin compound that inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM).

An irreversible antagonist of CXCR4 which suppresses infection by CXCR4-tropic HIV with an IC50 value of 1-10 ng/ml; mobilizes hematopoietic stem cells and progenitor cells as well as mature T-cells; regulates growth and metastasis of cancer cells.

A potent antagonist of calmodulin (IC₅₀ = 22 μM) that is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Differs from polymyxin B1 by having isoleucine rather than leucine as a component of the cyclic peptide; comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates.

An ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities, binding competitively to estrogen receptors and stimulating transactivation; changes reproductive organ and brain development in both males and females.

A dihydroxy PUFA and a hydrolysis product of LTA4.

A natural sapogenin that acts as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (EC₅₀ = 110 nM); up-regulates the expression of several RORα-inducible genes in the livers of mice, when given at 3 mg/kg/d orally for seven days.

A principal metabolite of L-deoxyalliin in humans, mice, rats, and dogs that is readily detected in plasma and urine.

An amine-reactive derivative of rhodamine that is used as a fluorescent label for antibodies and other probes (ex/em max = 552/575 nm).

PSN375963 is a potent and selective agonist of GPR119 that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 8.4 and 7.9 µM, respectively (EC50 values for OEA are 3.2 and 2.9 µM, respectively). These data suggest that PSN375963...

An isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 µM, respectively); induces apoptosis or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines; effective in vivo, suppressing MLL leukemia progression in two different mouse...

A cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties; commonly used as a standard or positive control in antioxidant assays.

A competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes metabolism of ethylene glycol and methanol to toxic metabolites; typically used as an antidote for ethylene glycol or methanol poisoning.

A PKC inhibitor (IC₅₀ = 62 nM) that is cytotoxic to the growth of HeLa S3 cells.

Cayman's ATP Detection Assay Kit - Luminescence provides a simple and effective tool for measuring total ATP levels. This assay uses firefly luciferase to convert ATP and luciferin to oxyluciferin and light. The light emitted in this reaction is directly proportional to the concentration of ATP...

A benzoquinone analog of coenzyme Q10; a potent lipid antioxidant that prevents the generation of free radicals; targets mitochondria, preserves mitochondrial function, and confers cytoprotection; neuroprotective and has applications in Friedreich ataxia.

A classical inhibitor of complex I of the mitochondrial electron transport chain, inhibiting NADH/DB oxidoreductase and NADH oxidase with IC₅₀ values of 28.8 and 5.1 nM, respectively; used in animal models of Parkinson’s disease.

A cell-permeable cAMP analog with improved lipophilicity compared to the PKA activators, 8-bromo-cAMP and Sp-cyclic AMPS; not readily degraded by PDE.

The DHA Quant-PAK has been designed for the convenient, precise quantification of DHA by GC- or LC-MS. It includes a 50 µg vial of DHA-d5 and a precisely weighed vial of unlabeled DHA, with the precise weight (2-4 mg) indicated on the vial. This unlabeled DHA can be used to quantify the DHA-d5...

A macrolide antibiotic with antifungal activity; also cytotoxic against trypanosomes (IC₅₀ = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells; inhibits bacterial and mitochondrial ATP synthases.

Antigen: amino acids around phospho-Ser392 Host: rabbit Application(s): WB Nearly 50% of human tumors have mutated or non-functional p53. p53 amino acid residues can be modified by phosphorylation and acetylation. In vivo phosphorylation of p53 residues alters signal transduction events that warrant...