Cayman Chemical

A potent, selective, reversible inhibitor of epidermal growth factor receptor (EGFR) kinase (Ki = 5.2 pM; IC₅₀ = 29 pM); rapidly suppresses autophosphorylation of EGFR in ?broblasts and human epidermoid carcinoma cells.

Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.{12450} Three major metabolites of tibolone are responsible for its tissue selective mechanism of action....

A macrolide antibiotic with effectiveness against pneumococci, Streptococcus, Listeria, Corynebacterium, and Helicobacter.

A long chain saturated fatty acid ethyl ester found in small quantities in liverwort, C. concium.

15(R) stereoisomer of PGA1

An inhibitor of ethylene biosynthesis that, at 1 µM, blocks the activity of both ACSs and ACOs; reduces ethylene-mediated plant changes in growth and development; inhibits cystathionine γ-lyase (Ki = 10.5 μM) with slow- and tight-binding characteristics.

A potent inhibitor of HIV-1 protease (Ki = 1.3 pM) that blocks the replication of laboratory and clinical strains of HIV-1 (EC₅₀ = 6-17 nM) and is effective against certain mutant strains.

Host: rat Cross Reactivity: (+) mouse podoplanin Application(s): FC and WB

PND1186 is a potent reversible focal adhesion kinase (FAK) inhibitor with an IC₅₀ value of 1.5 nM against the recombinant enzyme and 100 nM in breast carcinoma cells. It promotes 4T1 breast carcinoma and ID8 ovarian carcinoma cell apoptosis when grown in anchorage-independent 3D cultures...

CAS Number: 544686-21-7 Synonyms: SC-58635-d₄; YM-177-d₄ Molecular Formula: C₁₇H₇D₇F₃N₃O₂S Formula Weight: 388.4

An internal standard for the quantification of HMG-CoA by GC- or LC-MS.

An ERα selective agonist with a 410-fold relative binding affinity for ERα versus ERβ.

A potential metabolite of PGE2, presumably produced from the known metabolite 13,14-dihydro-15-keto PGE2.

The p-(p-acetamidobenzamido) phenyl ester is a crystalline derivative of 16,16-dimethyl PGE2 and a potential prodrug.

An echinocandin antifungal that inhibits 1,3-β-D-glucan synthesis; has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp.

Antigen: human endothelial lipase amino acids 19-32 Host: rabbit Cross Reactivity: (+) human, mouse, rat, porcine, and ovine endothelial lipase Application(s): IHC and WB EL is a major genetic determinant for the concentration, structure, and metabolism of HDL, which protects against...

A rotenoid that exhibits antineoplastic and piscicidal activities; inhibits the NADH:ubiquinone oxidoreductase (IC₅₀ = 98 nM) and induces ornithine decarboxylase activity (IC₅₀ = 147 nM).

A cell-permeable derivative of the L-isomer of 2-HG.

Molecular Formula: C₂₈H₂₄F₃N₇O₂

A potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM); inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto PGF1α production in a rat model of ionophore-induced peritoneal eicosanoid production.

A biochemical intermediate involved in the anaerobic metabolism of glutamate through the methylaspartate pathway of C. tetanomorphum; also plays various roles in other aspects of bacterial metabolism.

A gold-thiol complex with anti-inflammatory and immunosuppressive actions; potently inhibits thioredoxin reductase (IC₅₀ = 0.2 μM); blocks LPS-mediated expression of inflammatory mediators at 10-20 μM and blocks NF-κB signaling; has applications in rheumatoid arthritis.

A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~7 µM); promotes the growth of HCT-116 cells ~20% at concentrations at or below 1 µM.

An unsaturated cuticular hydrocarbon that acts as a pheromone in some insects, including Drosophila; abundant only in males of D. melanogaster and D. sechellia; prevents or reduces male courtship behavior and increases female sexual receptivity.