Cayman Chemical

Inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 µM; exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

15(S)-HETE is produced from arachidonic acid by the enzyme 15-LO. In humans it is formed primarily in the respiratory epithelium, leukocytes, and reticulocytes. It may contribute to allergic rhinitis, has anti-inflammatory properties, and acts as a vasoconstrictor. Cayman’s 15(S)-HETE ELISA is...

(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers (Item Nos. 34560 and 34570). It aggregates neutrophils with an EC₅₀ value...

Aconitase is an iron-sulfur protein containing a [Fe4S4]2+ cluster that catalyzes the stereospecific isomerization of citrate to isocitrate via cis-aconitate. Whereas exposure of aconitase to oxidants renders the enzyme inactive, loss of aconitase activity in cells or in biological samples treated...

4-Cyanoindole is a synthetic intermediate useful for pharmaceutical synthesis.

An internal standard for the quantification of stearoyl ethanolamide by GC- or LC-MS.

Enterolactone is a mammalian lignan with an estrogen-like diphenolic structure. It is produced by intestinal bacteria from two plant precursors (matairesinol and secoisolariciresinol) obtained in the diet. Enterolactone and other lignans and phytoestrogens have been associated with a reduced risk of...

A non-steroidal anti-inflammatory drug that inhibits COX-1 (IC₅₀ = 2.2 μM) and COX-2 (IC₅₀ = 36 μM) in human synovial cells; inhibits TXB2 production in human platelets (IC₅₀ = ~2 μM) and PGE2 production by human synovial cells (IC₅₀ = ~20 μM).

A potent, irreversible inhibitor of LSD1 (IC₅₀ = 70 nM); penetrates the blood-brain barrier and blocks long-term but not short-term memory in mice.

A selective inhibitor of VEGFR kinase activity (IC₅₀s = 170, 160, and 125 nM for VEGFR1, 2, and 3, respectively); suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity.

A potent inhibitor of kynurenine 3-hydroxylase (IC₅₀ = 37 nM), preventing the conversion of kynurenine to 3-hydroxy kynurenine; reduces ischemia-mediated neuronal damage in tissues; can be used in vivo by direct injection.

Interleukin-6 (IL-6) is produced by monocytes, macrophages, and T cells and is invovled in many defense mechanisms including the immune response, hematopoiesis, bone metabolism, and acute phase reactions. Cayman’s IL-6 (mouse) ELISA Kit is an immunometric (i.e., sandwich) ELISA that permits...

4-Pyrimidine methanamine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.

The inactive stereoisomer of a selective BET bromodomain inhibitor.

A fatty acid amide from T. titanicus that at 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.

CAS Number: 873786-09-5 Molecular Formula: C₂₁H₁₇F₃N₄ Formula Weight: 382.4

An inhibitor of the catalytic site of mTOR, inhibiting both mTORC1 and mTORC2 (IC₅₀s = 22 and 65 nM, respectively); prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 µM; effective in vivo.

An EPA-containing MAG amide analog that inhibits the growth of human lung carcinoma A549 cells, producing 98.4% growth inhibition when applied at 3 µM; an analog of EPEA, a natural N-acylethanolamide that impacts aging and inflammation.

Antigen: synthetic peptide from human histone H2A amino acids 1-15 and 81-96 Host: rabbit Cross Reactivity: (+) human and mouse histone H2A Application(s): ELISA and WB

A cannabimimetic with a relatively low-affinity for the CB1 receptor (Ki = 855 nM); interferes with the action of the potent CB1 agonist WIN 55,212-2, suggesting that it acts as a silent CB1 antagonist; reduces food intake and body weight gain in obese Zucker rats.

A potent, non-selective inhibitor of PKA with an IC50 value of 0.14 µM (Ki = 48 nM) that is widely used to disrupt PKA signaling; inhibits S6K1, MSK1, ROCK-II, PKBa, and MAPKAP-K1b with IC50 values of 0.08, 0.12, 0.27, 2.6, and 2.8 µM, respectively.

D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P4 increases intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release...

An inactive control to be used in experiments with AGK2; has IC₅₀ values greater than 50 µM on SIRT1 and SIRT2 and greater than 5 µM on SIRT3.

CAS Number: 515141-51-2 Molecular Formula: C₂₅H₂₄ClN₃O₃S Formula Weight: 482.0