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A colorimetric substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4.
A fluorometric probe that acts as a substrate for CYP3A4; typically used near its apparent Km value of 30 µM to screen the inhibition/activation potential of test compounds and to predict potential drug-drug interactions.
An inhibitor of parasitic and mammalian peroxiredoxins (T. gondii peroxiredoxin II (IC50 = 23 µM), A. ceylanicum peroxiredoxin I, and mammalian peroxiredoxin I and II (5 µM)).
An agonist of TGR5 (EC50 = 0.82 µM); stimulates the secretion of GLP-1 in mice when given orally (30 mg/kg) after a glucose challenge, particularly when given with a DPP4 inhibitor; increases energy expenditure and reduces hepatic steatosis and adiposity in mice subjected to...
A first generation tyrosine kinase inhibitor that is used in the treatment of CML, GIST, and other cancers; selectively targets certain tyrosine kinases, including c-ABL, PDGFR, KIT, and the oncoprotein BCR-ABL.
A lidocaine impurity.
A selective antagonist of EP4 (Ki = 3.2 nM) that less potently binds EP2 (Ki = 630 nM) and has no affinity for EP1 or EP3; delays the healing of gastric ulcers, suppressing the upregulation of VEGF expression and angiogenesis; blocks pain and inflammation in rat models of arthritis and gastric...
An alkyl salicylic acid isolated from cashew shells; inhibits the HAT activity of p300 and PCAF (IC50 = 8.5 and 5 µM, respectively); suppresses NF-κB activation, inhibits IκBα phosphorylation, and prohibits p65 nuclear translocation.
A minor constituent of ruminant fats with potential antitumor activity.
The C-15 oxidized derivative of iloprost, a second generation structural analog of prostaglandin I2 (prostacyclin).
A mixture of cyclohexadepsipeptides commonly isolated from fungi that act as ionophores, forming pores in cellular membranes to allow selective ion transport; exhibits antimicrobial activity against a variety of eukaryotic and prokaryotic genera, inhibits acyl-CoA:cholesterol acyltranferase, and...
A lignan found in the fruits of several species of the Schisandra genus that is reported to have liver-protective, antitumor, antioxidant, cardioprotective, anti-inflammatory, and neuroprotective activities in various research models.
A polyclonal anti-choleragenoid from goat that is suitable for use in toxin neutralization and binding assays or for immunohistochemical studies in conjunction with the cholera toxin B subunit.
A potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC50 = 3.3 nM); significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells; also blocks the interaction of Spindlin1 with H3K4me3 by binding with a Spindlin1 Tudor...
An α-hydroxy acid, overproduced in 2-hydroxyglutaric aciduria; mutations in IDH1 and IDH2 cause these enzymes to convert isocitrate to 2-hydroxyglutarate; competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.
A prominent autoxidation product of either trilinolein or arachidonic acid.
A potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50 = 9 nM); displays neuroprotectant effects in cortical neurons in vitro (IC50 = 0.04-0.4 μM).
Peptide sequence: N-terminal acetylated-PGP N-acetyl-PGP is a tripeptide that functions as a neutrophil chemoattractant. N-acetyl-PGP and PGP induce the recruitment of neutrophils (PMN) through stimulation of chemokine CXC receptors.
A selective mGluR1 PAM (EC50s = 0.39 and 0.36 μM for human and rat receptors, respectively) with no activity as a mGlu4 PAM (EC50 >10 μM); potentiates a response to glutamate in wild-type cell lines stably expressing mGlu1 and partially restores the reduction in...
A fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone.
A mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.
13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid. It is synthesized in human platelets, but its specific function is not known.
A formulation with greater solubility in organic solvents than standard SB 203580.
Antigen: nitrotyrosine-containing synthetic peptide Host: rabbit Cross Reactivity: (+) nitrotyrosine (species independent), less than 10% reactivity with chlorotyrosine; (−) synthetic peptide containing unmodified tyrosine Application(s): WB Cayman’s nitrotyrosine (peptide) polyclonal...